protein FANCN [Fanconi Anemia Complementation Group N Protein]

tematický
4
Termíny

protein PALB2

 

FANCN Protein
PALB2 Protein
Partner and Localizer of BRCA2 Protein

Perzistentní odkaz   https://www.medvik.cz/link/D000076164
Definice

A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.

DUI
D000076164 MeSH Prohlížeč
CUI
M000632389
Předchozí užití
Nuclear Proteins (2006-2017); Tumor Suppressor Proteins (2006-2017)
Historická pozn.
2018
Veřejná pozn.
2018

Povolená podhesla

AG
agonisté 0
AN
analýza 0
AI
antagonisté a inhibitory 0
AD
aplikace a dávkování 0
BI
biosyntéza 0
CS
chemická syntéza 0
CH
chemie 0
HI
dějiny 0
EC
ekonomika 0
PK
farmakokinetika 0
PD
farmakologie 0
PH
fyziologie 0
GE
genetika 3
IM
imunologie 0
IP
izolace a purifikace 0
CL
klasifikace 0
BL
krev 0
ME
metabolismus 0
UR
moč 0
CF
mozkomíšní mok 0
DF
nedostatek 0
ST
normy 0
PO
otrava 0
AE
škodlivé účinky 0
TU
terapeutické užití 0
TO
toxicita 0
DE
účinky léků 0
RE
účinky záření 0
UL
ultrastruktura 0
SD
zásobování a distribuce 0

D Chemikálie a léčiva
D12 aminokyseliny, peptidy a proteiny 16
D12.776 proteiny 2 575
D12.776.313 proteiny FANC 6
D12.776.313.125 protein BRCA1 101
D12.776.313.249 protein BRCA2 95
D12.776.313.500 protein FANCA 1
D12.776.313.750 protein FANCC 1
D12.776.313.812 protein FANCD2 4
D12.776.313.843 protein FANCE
D12.776.313.875 protein FANCF
D12.776.313.906 protein FANCG 2
D12.776.313.937 protein FANCL 2
D12.776.313.953 protein FANCN 4
D12.776.313.968 rekombinasa Rad51 42
D12.776.624 nádorové proteiny 411
D12.776.624.776 nádorové supresorové proteiny 265
D12.776.624.776.010 protein familiární adenomatózní polypózy 13
D12.776.624.776.021 receptor DCC
D12.776.624.776.051 protein FANCN 4
D12.776.624.776.100 protein BRCA1 101
D12.776.624.776.101 protein BRCA2 95
D12.776.624.776.355 inhibiční proteiny cyklin-dependentních kinas 42
D12.776.624.776.418 cystatin M
D12.776.624.776.482 deubikvitinizační enzym CYLD 1
D12.776.624.776.503 protein ING1
D12.776.624.776.523 protein Kangai-1 1
D12.776.624.776.546 kisspeptiny 6
D12.776.624.776.610 neurofibromin 1 14
D12.776.624.776.612 neurofibromin 2 3
D12.776.624.776.633 Patched receptory
D12.776.624.776.654 protein promyelocytické leukemie 4
D12.776.624.776.695 fosfohydroláza PTEN 49
D12.776.624.776.717 protein p107 podobný retinoblastomu 4
D12.776.624.776.735 protein p130 podobný retinoblastomu 5
D12.776.624.776.745 retinoblastomový protein 52
D12.776.624.776.760 protein Smad4 7
D12.776.624.776.766 hamartin 7
D12.776.624.776.769 tuberin 9
D12.776.624.776.772 nádorový supresorový protein p14ARF 4
D12.776.624.776.775 nádorový supresorový protein p53 754
D12.776.624.776.820 protein p73 6
D12.776.624.776.865 nádorový supresorový protein VHL 30
D12.776.624.776.960 proteiny WT1 29
D12.776.624.776.980 oxidoreduktasa obsahující WW doménu 1
D12.776.660 jaderné proteiny 451
D12.776.660.049 homeodoménový protein Antennapedia 1
D12.776.660.075 ataxiny 2
D12.776.660.100 protein BRCA1 101
D12.776.660.105 protein BRCA2 95
D12.776.660.167 proteiny vázající zesilovač transkripce CCAAT 11
D12.776.660.201 transkripční faktor CDX2 3
D12.776.660.235 chromozomální proteiny, nehistonové 93
D12.776.660.264 protein FANCA 1
D12.776.660.285 protein FANCD2 4
D12.776.660.289 protein FANCE
D12.776.660.293 protein FANCF
D12.776.660.323 protein FANCN 4
D12.776.660.338 proteiny GADD45
D12.776.660.352 hepatocytární jaderné faktory 5
D12.776.660.415 homeoboxový protein Nkx-2.2
D12.776.660.478 faktor C1 hostitelské buňky 2
D12.776.660.486 protein RBP-Jkappa
D12.776.660.494 protein ING1
D12.776.660.502 karyoferiny 9
D12.776.660.526 Mad2 protein 1
D12.776.660.551 mediátorový komplex 5
D12.776.660.600 NF-kappa B 209
D12.776.660.625 antigeny jaderné 11
D12.776.660.650 proteiny asociované s jadernou matrix 2
D12.776.660.675 koaktivátory jaderných receptorů 6
D12.776.660.688 nuclear receptor interacting protein 1 3
D12.776.660.691 nukleolin
D12.776.660.694 nukleofosmin 17
D12.776.660.700 onkogenní protein p55(v-myc) 1
D12.776.660.720 proteiny vázající poly-ADP-ribosu 5
D12.776.660.740 proliferační antigen buněčného jádra 60
D12.776.660.745 protein promyelocytické leukemie 4
D12.776.660.750 protaminy 42
D12.776.660.760 protoonkogenní proteiny c-fos 61
D12.776.660.763 protoonkogenní proteiny c-jun 17
D12.776.660.764 protoonkogenní proteiny c-mdm2 65
D12.776.660.765 protoonkogenní proteiny c-myc 66
D12.776.660.767 protoonkogenní proteiny c-rel 2
D12.776.660.768 Ran protein vázající GTP 4
D12.776.660.769 vazebné proteiny retinoblastomu 3
D12.776.660.770 protein p107 podobný retinoblastomu 4
D12.776.660.794 protein p130 podobný retinoblastomu 5
D12.776.660.807 retinoblastomový protein 52
D12.776.660.820 proteiny regulace mlčící informace, Saccharomyces cerevisiae
D12.776.660.823 tyreoidální jaderný faktor 1
D12.776.660.912 protein p73 6

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