c-Mer Tyrosine Kinase [tyrosinkinasa c-Mer]

topical
2
Terms

MERTK
tyrosinkináza c-Mer
tyrozinkináza c-Mer

 

c-Mer Proto-Oncogene Tyrosine Kinase
MERTK

Persistent link   https://www.medvik.cz/link/D000076202
Definition

A receptor tyrosine kinase that transduces signals from EXTRACELLULAR MATRIX to the CYTOPLASM by binding ligands such as GALECTIN 3. It regulates many physiologic processes that include cell survival, migration, differentiation, and PHAGOCYTOSIS of apoptotic cells and ROD PHOTORECEPTORS in the RETINAL PIGMENT EPITHELIUM. Mutations in the MERTK gene are associated with type 38 RETINITIS PIGMENTOSA; it also plays a critical role as an inhibitor of TOLL-LIKE RECEPTORS signaling.

DUI
D000076202 MeSH Browser
CUI
M000632438
Previous indexing
Proto-Oncogene Proteins (1999-2017); Receptor Protein-Tyrosine Kinases (1999-2017)
History note
2018
Public note
2018

Allowable subheadings

AD
administration & dosage 0
AG
agonists 0
AN
analysis 0
AI
antagonists & inhibitors 0
BI
biosynthesis 0
BL
blood 0
CH
chemistry 0
CL
classification 0
DF
deficiency 0
DE
drug effects 0
GE
genetics 2
HI
history 0
IM
immunology 0
IP
isolation & purification 0
ME
metabolism 2
PH
physiology 0
RE
radiation effects 0
TU
therapeutic use 0
UL
ultrastructure 0

D Chemicals and Drugs
D08 Enzymes and Coenzymes 7
D08.811 Enzymes 1 547
D08.811.913 Transferases 72
D08.811.913.696 Phosphotransferases 69
D08.811.913.696.620 Phosphotransferases (Alcohol Group Acceptor) 32
D08.811.913.696.620.682 Protein Kinases 248
D08.811.913.696.620.682.725 Protein-Tyrosine Kinases 620
D08.811.913.696.620.682.725.400 Receptor Protein-Tyrosine Kinases 148
D08.811.913.696.620.682.725.400.002 Anaplastic Lymphoma Kinase 83
D08.811.913.696.620.682.725.400.003 c-Mer Tyrosine Kinase 2
D08.811.913.696.620.682.725.400.005 Discoidin Domain Receptors
D08.811.913.696.620.682.725.400.009 ErbB Receptors 798
D08.811.913.696.620.682.725.400.020 fms-Like Tyrosine Kinase 3 49
D08.811.913.696.620.682.725.400.050 Proto-Oncogene Proteins c-kit 77
D08.811.913.696.620.682.725.400.075 Proto-Oncogene Proteins c-met 30
D08.811.913.696.620.682.725.400.087 Proto-Oncogene Proteins c-ret 42
D08.811.913.696.620.682.725.400.093 Receptor Tyrosine Kinase-like Orphan Receptors 8
D08.811.913.696.620.682.725.400.177 Receptor, Fibroblast Growth Factor, Type 1 11
D08.811.913.696.620.682.725.400.178 Receptor, Fibroblast Growth Factor, Type 2 2
D08.811.913.696.620.682.725.400.179 Receptor, Fibroblast Growth Factor, Type 3 27
D08.811.913.696.620.682.725.400.180 Receptor, Fibroblast Growth Factor, Type 4 3
D08.811.913.696.620.682.725.400.185 Receptor, IGF Type 1 43
D08.811.913.696.620.682.725.400.200 Receptor, Insulin 68
D08.811.913.696.620.682.725.400.500 Receptor, Macrophage Colony-Stimulating Factor 1
D08.811.913.696.620.682.725.400.660 Receptor, trkA 14
D08.811.913.696.620.682.725.400.700 Receptor, trkB 7
D08.811.913.696.620.682.725.400.800 Receptor, trkC 15
D08.811.913.696.620.682.725.400.850 Receptors, Eph Family 1
D08.811.913.696.620.682.725.400.900 Receptors, Platelet-Derived Growth Factor 33
D08.811.913.696.620.682.725.400.925 Receptors, TIE 5
D08.811.913.696.620.682.725.400.950 Receptors, Vascular Endothelial Growth Factor 350
D08.811.913.696.620.682.725.400.975 Axl Receptor Tyrosine Kinase
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 575
D12.776.476 Intracellular Signaling Peptides and Proteins 174
D12.776.476.568 Protein-Tyrosine Kinases 620
D12.776.476.568.400 Receptor Protein-Tyrosine Kinases 148
D12.776.476.568.400.002 Anaplastic Lymphoma Kinase 83
D12.776.476.568.400.003 c-Mer Tyrosine Kinase 2
D12.776.476.568.400.005 Discoidin Domain Receptors
D12.776.476.568.400.009 ErbB Receptors 798
D12.776.476.568.400.020 fms-Like Tyrosine Kinase 3 49
D12.776.476.568.400.050 Proto-Oncogene Proteins c-kit 77
D12.776.476.568.400.075 Proto-Oncogene Proteins c-met 30
D12.776.476.568.400.087 Proto-Oncogene Proteins c-ret 42
D12.776.476.568.400.093 Receptor Tyrosine Kinase-like Orphan Receptors 8
D12.776.476.568.400.177 Receptor, Fibroblast Growth Factor, Type 1 11
D12.776.476.568.400.178 Receptor, Fibroblast Growth Factor, Type 2 2
D12.776.476.568.400.179 Receptor, Fibroblast Growth Factor, Type 3 27
D12.776.476.568.400.180 Receptor, Fibroblast Growth Factor, Type 4 3
D12.776.476.568.400.185 Receptor, IGF Type 1 43
D12.776.476.568.400.200 Receptor, Insulin 68
D12.776.476.568.400.500 Receptor, Macrophage Colony-Stimulating Factor 1
D12.776.476.568.400.660 Receptor, trkA 14
D12.776.476.568.400.700 Receptor, trkB 7
D12.776.476.568.400.800 Receptor, trkC 15
D12.776.476.568.400.850 Receptors, Eph Family 1
D12.776.476.568.400.900 Receptors, Platelet-Derived Growth Factor 33
D12.776.476.568.400.925 Receptors, TIE 5
D12.776.476.568.400.950 Receptors, Vascular Endothelial Growth Factor 350
D12.776.476.568.400.975 Axl Receptor Tyrosine Kinase
D12.776.543 Membrane Proteins 849
D12.776.543.750 Receptors, Cell Surface 511
D12.776.543.750.630 Receptor Protein-Tyrosine Kinases 148
D12.776.543.750.630.002 Anaplastic Lymphoma Kinase 83
D12.776.543.750.630.003 c-Mer Tyrosine Kinase 2
D12.776.543.750.630.005 Discoidin Domain Receptors
D12.776.543.750.630.009 ErbB Receptors 798
D12.776.543.750.630.020 fms-Like Tyrosine Kinase 3 49
D12.776.543.750.630.124 Proto-Oncogene Proteins c-kit 77
D12.776.543.750.630.186 Proto-Oncogene Proteins c-met 30
D12.776.543.750.630.217 Proto-Oncogene Proteins c-ret 42
D12.776.543.750.630.233 Receptor Tyrosine Kinase-like Orphan Receptors 8
D12.776.543.750.630.440 Receptor, Fibroblast Growth Factor, Type 1 11
D12.776.543.750.630.441 Receptor, Fibroblast Growth Factor, Type 2 2
D12.776.543.750.630.442 Receptor, Fibroblast Growth Factor, Type 3 27
D12.776.543.750.630.443 Receptor, Fibroblast Growth Factor, Type 4 3
D12.776.543.750.630.468 Receptor, IGF Type 1 43
D12.776.543.750.630.484 Receptor, Insulin 68
D12.776.543.750.630.492 Receptor, Macrophage Colony-Stimulating Factor 1
D12.776.543.750.630.496 Receptor, trkA 14
D12.776.543.750.630.498 Receptor, trkB 7
D12.776.543.750.630.499 Receptor, trkC 15
D12.776.543.750.630.500 Receptors, Eph Family 1
D12.776.543.750.630.625 Receptors, Platelet-Derived Growth Factor 33
D12.776.543.750.630.687 Receptors, TIE 5
D12.776.543.750.630.750 Receptors, Vascular Endothelial Growth Factor 350
D12.776.543.750.630.875 Axl Receptor Tyrosine Kinase
D12.776.624 Neoplasm Proteins 411
D12.776.624.664 Oncogene Proteins 125
D12.776.624.664.700 Proto-Oncogene Proteins 263
D12.776.624.664.700.013 Axl Receptor Tyrosine Kinase
D12.776.624.664.700.025 Bcl-2-Like Protein 11 5
D12.776.624.664.700.037 c-Mer Tyrosine Kinase 2
D12.776.624.664.700.049 Chemokine CXCL1 7
D12.776.624.664.700.100 Cyclin D1 86
D12.776.624.664.700.110 Fibroblast Growth Factor 4 2
D12.776.624.664.700.112 Fibroblast Growth Factor 6
D12.776.624.664.700.114 fms-Like Tyrosine Kinase 3 49
D12.776.624.664.700.117 Janus Kinase 2 79
D12.776.624.664.700.119 KRIT1 Protein
D12.776.624.664.700.120 Kruppel-Like Factor 6 1
D12.776.624.664.700.123 Lipocalin-2 21
D12.776.624.664.700.128 Lymphocyte Specific Protein Tyrosine Kinase p56(lck) 10
D12.776.624.664.700.129 MDS1 and EVI1 Complex Locus Protein 2
D12.776.624.664.700.130 MutS Homolog 2 Protein 17
D12.776.624.664.700.148 Myeloid-Lymphoid Leukemia Protein 39
D12.776.624.664.700.158 N-Myc Proto-Oncogene Protein 9
D12.776.624.664.700.163 Pre-B-Cell Leukemia Transcription Factor 1 2
D12.776.624.664.700.165 B-Cell Lymphoma 3 Protein
D12.776.624.664.700.166 Proto-Oncogene Mas 2
D12.776.624.664.700.167 Proto-Oncogene Proteins c-abl 7
D12.776.624.664.700.168 Proto-Oncogene Proteins c-akt 116
D12.776.624.664.700.169 Proto-Oncogene Proteins c-bcl-2 147
D12.776.624.664.700.170 Proto-Oncogene Proteins c-bcl-6 3
D12.776.624.664.700.171 Proto-Oncogene Proteins c-bcr 19
D12.776.624.664.700.172 Proto-Oncogene Proteins c-cbl 5
D12.776.624.664.700.174 Proto-Oncogene Proteins c-crk 1
D12.776.624.664.700.175 Proto-Oncogene Proteins c-ets 19
D12.776.624.664.700.177 Proto-Oncogene Proteins c-fes
D12.776.624.664.700.179 Proto-Oncogene Proteins c-fos 61
D12.776.624.664.700.180 Proto-Oncogene Proteins c-fyn 4
D12.776.624.664.700.181 Proto-Oncogene Proteins c-hck 1
D12.776.624.664.700.182 Proto-Oncogene Proteins c-jun 17
D12.776.624.664.700.183 Proto-Oncogene Proteins c-kit 77
D12.776.624.664.700.184 Proto-Oncogene Proteins c-maf 1
D12.776.624.664.700.185 Proto-Oncogene Proteins c-mdm2 65
D12.776.624.664.700.186 Proto-Oncogene Proteins c-met 30
D12.776.624.664.700.187 Proto-Oncogene Proteins c-mos 2
D12.776.624.664.700.188 Proto-Oncogene Proteins c-myb 30
D12.776.624.664.700.189 Proto-Oncogene Proteins c-myc 66
D12.776.624.664.700.191 Proto-Oncogene Proteins c-pim-1 1
D12.776.624.664.700.192 Proto-Oncogene Proteins c-rel 2
D12.776.624.664.700.194 Proto-Oncogene Proteins c-ret 42
D12.776.624.664.700.195 Proto-Oncogene Proteins c-sis 3
D12.776.624.664.700.198 Proto-Oncogene Proteins c-vav 4
D12.776.624.664.700.199 Proto-Oncogene Proteins c-yes 1
D12.776.624.664.700.200 Proto-Oncogene Proteins p21(ras) 71
D12.776.624.664.700.202 Proto-Oncogene Proteins pp60(c-src) 7
D12.776.624.664.700.204 raf Kinases 70
D12.776.624.664.700.642 Receptor, ErbB-2 584
D12.776.624.664.700.790 Receptor, ErbB-3 9
D12.776.624.664.700.791 Receptor, ErbB-4
D12.776.624.664.700.792 Receptor, Fibroblast Growth Factor, Type 3 27
D12.776.624.664.700.800 Receptor, Macrophage Colony-Stimulating Factor 1
D12.776.624.664.700.815 Receptor, Notch4
D12.776.624.664.700.830 Receptors, Thyroid Hormone 40
D12.776.624.664.700.913 RNA-Binding Protein EWS 15
D12.776.624.664.700.915 RNA-Binding Protein FUS 6
D12.776.624.664.700.936 RUNX1 Translocation Partner 1 Protein
D12.776.624.664.700.957 Stathmin 4
D12.776.624.664.700.960 T-Cell Acute Lymphocytic Leukemia Protein 1
D12.776.624.664.700.962 Wnt-5a Protein 5
D12.776.624.664.700.967 Wnt1 Protein 4
D12.776.624.664.700.978 Wnt2 Protein
D12.776.624.664.700.989 Zinc Finger Protein GLI1 7

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