The first complement component to act in the activation of CLASSICAL COMPLEMENT PATHWAY. It is a calcium-dependent trimolecular complex made up of three subcomponents: COMPLEMENT C1Q; COMPLEMENT C1R; and COMPLEMENT C1S at 1:2:2 ratios. When the intact C1 binds to at least two antibodies (involving C1q), C1r and C1s are sequentially activated, leading to subsequent steps in the cascade of COMPLEMENT ACTIVATION.

Anotace

/antag permitted but consider also COMPLEMENT C1 INACTIVATOR PROTEINS

DUI

D003172 MeSH Prohlížeč

CUI

M0004924

Předchozí užití

Calcium (1966-1974); Complement (1968-1974)

Historická pozn.

2006 (1975)

Veřejná pozn.

2006; see COMPLEMENT 1 1978-2005, see COMPLEMENT 1975-1977