cytochrom P450 CYP2C8 [Cytochrome P-450 CYP2C8]

tematický
8
Termíny

CYP2C8
CYPIIC8
cytochrom P-450 CYP2C8

 

CYP2C8
CYPIIC8
Cytochrome P450 MP-20
Cytochrome P450, Family 2, Subfamily C, Polypeptide 8
S-Mephenytoin 4-Hydroxylase

Perzistentní odkaz   https://www.medvik.cz/link/D065727
Definice

Jaterní mikrozomální hydroxyláza cytochromu P450, která oxiduje široké spektrum substrátů včetně steroidů, mastných kyselin a xenobiotik. K farmaceutickým substrátům pro CYP2C8 patří paclitaxel, torsemid a amodiachin.

A liver microsomal cytochrome P450 hydroxylase that oxidizes a broad spectrum of substrates including STEROIDS, FATTY ACIDS, and XENOBIOTICS. Examples of pharmaceutical substrates for CYP2C8 include; PACLITAXOL; torsemide; and; AMODIAQUINE

DUI
D065727 MeSH Prohlížeč
CUI
M0590595
Předchozí užití
Aryl Hydrocarbon Hydroxylases (2002-2014)
Historická pozn.
2015
Veřejná pozn.
2015

Kombinace

antagonisté a inhibitory
inhibitory cytochromu P450 CYP2C8

Povolená podhesla

AN
analýza
AD
aplikace a dávkování
BI
biosyntéza 2
CS
chemická syntéza
CH
chemie
HI
dějiny
EC
ekonomika
PK
farmakokinetika
PD
farmakologie
PH
fyziologie
GE
genetika 3
IM
imunologie
IP
izolace a purifikace
CL
klasifikace
BL
krev
ME
metabolismus 3
UR
moč
CF
mozkomíšní mok
DF
nedostatek
ST
normy
PO
otrava
AE
škodlivé účinky
TU
terapeutické užití
TO
toxicita
DE
účinky léků
RE
účinky záření
UL
ultrastruktura
SD
zásobování a distribuce

D Chemikálie a léčiva
D08 enzymy a koenzymy 7
D08.244 cytochromy 121
D08.244.453 systém (enzymů) cytochromů P-450 692
D08.244.453.005 aromatické hydroxylasy 80
D08.244.453.005.050 anilinhydroxylasa 1
D08.244.453.005.110 benzopyrenhydroxylasa
D08.244.453.005.332 cytochrom P-450 CYP1A1 172
D08.244.453.005.443 cytochrom P-450 CYP1A2 72
D08.244.453.005.500 cytochrom P450 CYP1B1 9
D08.244.453.005.550 cytochrom P-450 CYP2B1 4
D08.244.453.005.575 cytochrom P450 CYP2B6 9
D08.244.453.005.590 cytochrom P450 CYP2C8 8
D08.244.453.005.600 cytochrom P-450 CYP2D6 119
D08.244.453.491 rodina 2 cytochromů P450 4
D08.244.453.491.250 cytochrom P450 CYP2A6 8
D08.244.453.491.313 cytochrom P-450 CYP2B1 4
D08.244.453.491.344 cytochrom P450 CYP2B6 9
D08.244.453.491.368 cytochrom P450 CYP2C8 8
D08.244.453.491.372 cytochrom P-450 CYP2D6 119
D08.244.453.491.375 cytochrom P-450 CYP2E1 39
D08.244.453.491.500 limonenové hydroxylázy 1
D08.811 enzymy 1 547
D08.811.682 oxidoreduktasy 446
D08.811.682.690 oxygenasy 76
D08.811.682.690.708 oxygenasy se smíšenou funkcí 68
D08.811.682.690.708.170 systém (enzymů) cytochromů P-450 692
D08.811.682.690.708.170.010 aromatické hydroxylasy 80
D08.811.682.690.708.170.010.024 7-alkoxykumarin-O-dealkylasa
D08.811.682.690.708.170.010.050 anilinhydroxylasa 1
D08.811.682.690.708.170.010.110 benzopyrenhydroxylasa
D08.811.682.690.708.170.010.277 cytochrom P-450 CYP1A1 172
D08.811.682.690.708.170.010.443 cytochrom P-450 CYP1A2 72
D08.811.682.690.708.170.010.500 cytochrom P450 CYP1B1 9
D08.811.682.690.708.170.010.550 cytochrom P-450 CYP2B1 4
D08.811.682.690.708.170.010.575 cytochrom P450 CYP2B6 9
D08.811.682.690.708.170.010.590 cytochrom P450 CYP2C8 8
D08.811.682.690.708.170.010.600 cytochrom P-450 CYP2D6 119
D08.811.682.690.708.170.450 rodina 2 cytochromů P450 4
D08.811.682.690.708.170.450.250 cytochrom P450 CYP2A6 8
D08.811.682.690.708.170.450.313 cytochrom P-450 CYP2B1 4
D08.811.682.690.708.170.450.344 cytochrom P450 CYP2B6 9
D08.811.682.690.708.170.450.360 cytochrom P450 CYP2C8 8
D08.811.682.690.708.170.450.368 cytochrom P-450 CYP2D6 119
D08.811.682.690.708.170.450.375 cytochrom P-450 CYP2E1 39
D08.811.682.690.708.170.450.500 limonenové hydroxylázy 1
D12 aminokyseliny, peptidy a proteiny 16
D12.776 proteiny 2 577
D12.776.422 hemoproteiny 16
D12.776.422.220 cytochromy 121
D12.776.422.220.453 systém (enzymů) cytochromů P-450 692
D12.776.422.220.453.010 aromatické hydroxylasy 80
D12.776.422.220.453.010.050 anilinhydroxylasa 1
D12.776.422.220.453.010.110 benzopyrenhydroxylasa
D12.776.422.220.453.010.332 cytochrom P-450 CYP1A1 172
D12.776.422.220.453.010.443 cytochrom P-450 CYP1A2 72
D12.776.422.220.453.010.500 cytochrom P450 CYP1B1 9
D12.776.422.220.453.010.550 cytochrom P-450 CYP2B1 4
D12.776.422.220.453.010.575 cytochrom P450 CYP2B6 9
D12.776.422.220.453.010.590 cytochrom P450 CYP2C8 8
D12.776.422.220.453.010.600 cytochrom P-450 CYP2D6 119
D12.776.422.220.453.491 rodina 2 cytochromů P450 4
D12.776.422.220.453.491.250 cytochrom P450 CYP2A6 8
D12.776.422.220.453.491.313 cytochrom P-450 CYP2B1 4
D12.776.422.220.453.491.344 cytochrom P450 CYP2B6 9
D12.776.422.220.453.491.360 cytochrom P450 CYP2C8 8
D12.776.422.220.453.491.368 cytochrom P-450 CYP2D6 119
D12.776.422.220.453.491.375 cytochrom P-450 CYP2E1 39
D12.776.422.220.453.491.500 limonenové hydroxylázy 1

CYP2C8 protein, human Chemical MeSH Prohlížeč

CYP2C8 protein, mouse Chemical MeSH Prohlížeč

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