Since ochratoxin A (OTA) was discovered, it has been ubiquitous as a natural contaminant of moldy food and feed. The multiple toxic effects of OTA are a real threat for human beings and animal health. For example, OTA can cause porcine nephropathy but can also damage poultries. Humans exposed to OTA can develop (notably by inhalation in the development of acute renal failure within 24 h) a range of chronic disorders such as upper urothelial carcinoma. OTA plays the main role in the pathogenesis of some renal diseases including Balkan endemic nephropathy, kidney tumors occurring in certain endemic regions of the Balkan Peninsula, and chronic interstitial nephropathy occurring in Northern African countries and likely in other parts of the world. OTA leads to DNA adduct formation, which is known for its genotoxicity and carcinogenicity. The present article discusses how renal carcinogenicity and nephrotoxicity cause both oxidative stress and direct genotoxicity. Careful analyses of the data show that OTA carcinogenic effects are due to combined direct and indirect mechanisms (e.g., genotoxicity, oxidative stress, epigenetic factors). Altogether this provides strong evidence that OTA carcinogenicity can also occur in humans.
- MeSH
- balkánská nefropatie chemicky indukované genetika dějiny metabolismus MeSH
- dějiny 20. století MeSH
- dějiny 21. století MeSH
- epigeneze genetická účinky léků MeSH
- hodnocení rizik MeSH
- ledviny účinky léků metabolismus patologie MeSH
- lidé MeSH
- nádorová transformace buněk chemicky indukované genetika metabolismus MeSH
- nádory ledvin chemicky indukované genetika dějiny metabolismus MeSH
- ochratoxiny dějiny metabolismus toxicita MeSH
- oxidační stres účinky léků MeSH
- poškození DNA MeSH
- potravinářská mikrobiologie * dějiny trendy MeSH
- regulace genové exprese u nádorů účinky léků MeSH
- rizikové faktory MeSH
- toxikologie * dějiny trendy MeSH
- zvířata MeSH
- Check Tag
- dějiny 20. století MeSH
- dějiny 21. století MeSH
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- historické články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
