PURPOSE: The presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available. METHODS: Intervertebral disc tissue obtained from 54 microdiscectomy patients given prophylactic cefazolin (n = 25), clindamycin (n = 17) or vancomycin (n = 12) was assayed by high-performance liquid chromatography, with cefaclor as an internal standard, to determine the concentration of antibiotic penetrating into the disc tissue. RESULTS: Intervertebral disc tissues from patients receiving the positively charged antibiotic clindamycin contained a significantly greater percentage of the antibacterial dose than the tissue from patients receiving negatively charged cefazolin (P < 0.0001) and vancomycin, which has a slight positive charge (P < 0.0001). CONCLUSION: Positively charged antibiotics appear more appropriate for future studies investigating potential options for the treatment of low-virulence disc infections. These slides can be retrieved under Electronic Supplementary Material.
- MeSH
- antibakteriální látky farmakokinetika terapeutické užití MeSH
- cefazolin farmakokinetika terapeutické užití MeSH
- degenerace meziobratlové ploténky chirurgie MeSH
- dospělí MeSH
- grampozitivní bakteriální infekce prevence a kontrola MeSH
- klindamycin farmakokinetika terapeutické užití MeSH
- lidé MeSH
- meziobratlová ploténka metabolismus MeSH
- Propionibacterium acnes * MeSH
- vankomycin farmakokinetika terapeutické užití MeSH
- výhřez meziobratlové ploténky chirurgie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Unfortunately, the complete conflict of interest statement was missed out in the original publication. The same is given below.
- Publikační typ
- tisková chyba MeSH
