Obesity and arterial hypertension are a serious risk factor for insulin resistance patients leading to diabetes and other disorders. The aim of this study was to compare average levels of the homeostatic indices HOMA and QUICKI in obese children compared to healthy and hypertonic children in order to find convenient markers for insulin sensitivity in clinical pediatric practice. 21 obese, 29 healthy and 28 hypertonic children were selected. The average level of HOMA in obese children was 3.6; in healthy children 1.7 and in the group of hypertonic children the level was 2.65. The average level of QUICKI in obese children was 0.33; in healthy children 0.36 and in hypertonic children 0.34. The results demonstrate the possibility of insulin sensitivity assessment using these indices in pediatric practice. QUICKI has a narrower confidence interval and thus a lower variability.