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Autor
DiNardo, Courtney D 1 Döhner, Hartmut 1 Esteve, Jordi 1 Fenaux, Pierre 1 Garcia, Jacqueline S 1 Havelange, Violaine 1 Hong, Wan-Jen 1 Hájek, Roman 1 Illés, Árpád 1 Jang, Jun-Ho 1 Jonas, Brian A 1 Koller, Elizabeth 1 Konopleva, Marina 1 Lavie, David 1 Leber, Brian 1 Lemoli, Roberto M 1 Letai, Anthony 1 Pejsa, Vlatko 1 Porkka, Kimmo 1 Potluri, Jalaja 1
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Pracoviště
Abramson Cancer Center University of ... 1 From the Department of Leukemia Divis... 1 Hadassah Medical Center Jerusalem 1 Helsinki University Hospital Comprehe... 1 Hôpital St Louis Assistance Publique ... 1 the 3rd Medical Department for Hemato... 1 the Australian Centre for Blood Disea... 1 the Clinic of Hematology Department o... 1 the Department of Clinic Subjects Uni... 1 the Department of Hematology Clinique... 1 the Department of Hematology Hospital... 1 the Department of Hematology Universi... 1 the Department of Hematology and Cell... 1 the Department of Internal Medicine 3... 1 the Department of Internal Medicine C... 1 the Department of Internal Medicine D... 1 the Department of Internal Medicine S... 1 the Department of Medical Oncology Da... 1 the Department of Medicine McMaster U... 1 the Faculty of Medicine Department of... 1
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Autor
DiNardo, Courtney D 1 Döhner, Hartmut 1 Esteve, Jordi 1 Fenaux, Pierre 1 Garcia, Jacqueline S 1 Havelange, Violaine 1 Hong, Wan-Jen 1 Hájek, Roman 1 Illés, Árpád 1 Jang, Jun-Ho 1 Jonas, Brian A 1 Koller, Elizabeth 1 Konopleva, Marina 1 Lavie, David 1 Leber, Brian 1 Lemoli, Roberto M 1 Letai, Anthony 1 Pejsa, Vlatko 1 Porkka, Kimmo 1 Potluri, Jalaja 1
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Pracoviště
Abramson Cancer Center University of ... 1 From the Department of Leukemia Divis... 1 Hadassah Medical Center Jerusalem 1 Helsinki University Hospital Comprehe... 1 Hôpital St Louis Assistance Publique ... 1 the 3rd Medical Department for Hemato... 1 the Australian Centre for Blood Disea... 1 the Clinic of Hematology Department o... 1 the Department of Clinic Subjects Uni... 1 the Department of Hematology Clinique... 1 the Department of Hematology Hospital... 1 the Department of Hematology Universi... 1 the Department of Hematology and Cell... 1 the Department of Internal Medicine 3... 1 the Department of Internal Medicine C... 1 the Department of Internal Medicine D... 1 the Department of Internal Medicine S... 1 the Department of Medical Oncology Da... 1 the Department of Medicine McMaster U... 1 the Faculty of Medicine Department of... 1
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DiNardo, Courtney D
Autor DiNardo, Courtney D From the Department of Leukemia, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (C.D.D., M.K.) the Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento (B.A.J.), the Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte (V. Pullarkat), and Genentech, South San Francisco (W.-J.H.) - all in California the Section of Hematology and Oncology, Department of Medicine, University of Chicago Medicine, Chicago (M.J.T.), and AbbVie, North Chicago (Y.Z., J.P.) - both in Illinois the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston (J.S.G., A.L.) the Australian Centre for Blood Diseases, Alfred Hospital and Monash University, Melbourne, VIC (A.H.W.) the Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany (H.D.) Hôpital St. Louis, Assistance Publique-Hôpitaux de Paris and Université de Paris, Paris (P.F.) the Third Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna (E.K.) the Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels (V.H.) the Department of Medicine, McMaster University, Hamilton, ON, Canada (B.L.) the Department of Hematology, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, Barcelona (J.E.) the Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China (J.W.) the Department of Hematology, University Hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Croatia (V. Pejsa) the Department of Clinic Subjects, University Hospital Ostrava-Poruba, Ostrava, Czech Republic (R.H.) Helsinki University Hospital Comprehensive Cancer Center, University of Helsinki, Helsinki (K.P.) the Faculty of Medicine, Department of Hematology, University of Debrecen, Debrecen, Hungary (A.I.) Hadassah Medical Center, Jerusalem (D.L.) the Clinic of Hematology, Department of Internal Medicine, University of Genoa, and San Martino Hospital IRCCS - both in Genoa, Italy (R.M.L.) the Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan (K.Y.) the Department of Internal Medicine, Seoul National University College of Medicine (S.-S.Y.), and the Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine (J.-H.J.) - both in Seoul, South Korea the Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan (S.-P.Y.) the Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ondokuz Mayıs University, Samsun, Turkey (M.T.) and Abramson Cancer Center, University of Pennsylvania, Philadelphia (K.W.P.)
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Jonas, Brian A
Autor Jonas, Brian A From the Department of Leukemia, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (C.D.D., M.K.) the Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento (B.A.J.), the Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte (V. Pullarkat), and Genentech, South San Francisco (W.-J.H.) - all in California the Section of Hematology and Oncology, Department of Medicine, University of Chicago Medicine, Chicago (M.J.T.), and AbbVie, North Chicago (Y.Z., J.P.) - both in Illinois the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston (J.S.G., A.L.) the Australian Centre for Blood Diseases, Alfred Hospital and Monash University, Melbourne, VIC (A.H.W.) the Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany (H.D.) Hôpital St. Louis, Assistance Publique-Hôpitaux de Paris and Université de Paris, Paris (P.F.) the Third Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna (E.K.) the Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels (V.H.) the Department of Medicine, McMaster University, Hamilton, ON, Canada (B.L.) the Department of Hematology, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, Barcelona (J.E.) the Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China (J.W.) the Department of Hematology, University Hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Croatia (V. Pejsa) the Department of Clinic Subjects, University Hospital Ostrava-Poruba, Ostrava, Czech Republic (R.H.) Helsinki University Hospital Comprehensive Cancer Center, University of Helsinki, Helsinki (K.P.) the Faculty of Medicine, Department of Hematology, University of Debrecen, Debrecen, Hungary (A.I.) Hadassah Medical Center, Jerusalem (D.L.) the Clinic of Hematology, Department of Internal Medicine, University of Genoa, and San Martino Hospital IRCCS - both in Genoa, Italy (R.M.L.) the Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan (K.Y.) the Department of Internal Medicine, Seoul National University College of Medicine (S.-S.Y.), and the Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine (J.-H.J.) - both in Seoul, South Korea the Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan (S.-P.Y.) the Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ondokuz Mayıs University, Samsun, Turkey (M.T.) and Abramson Cancer Center, University of Pennsylvania, Philadelphia (K.W.P.)
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Pullarkat, Vinod
Autor Pullarkat, Vinod From the Department of Leukemia, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (C.D.D., M.K.) the Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento (B.A.J.), the Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte (V. Pullarkat), and Genentech, South San Francisco (W.-J.H.) - all in California the Section of Hematology and Oncology, Department of Medicine, University of Chicago Medicine, Chicago (M.J.T.), and AbbVie, North Chicago (Y.Z., J.P.) - both in Illinois the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston (J.S.G., A.L.) the Australian Centre for Blood Diseases, Alfred Hospital and Monash University, Melbourne, VIC (A.H.W.) the Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany (H.D.) Hôpital St. Louis, Assistance Publique-Hôpitaux de Paris and Université de Paris, Paris (P.F.) the Third Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna (E.K.) the Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels (V.H.) the Department of Medicine, McMaster University, Hamilton, ON, Canada (B.L.) the Department of Hematology, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, Barcelona (J.E.) the Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China (J.W.) the Department of Hematology, University Hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Croatia (V. Pejsa) the Department of Clinic Subjects, University Hospital Ostrava-Poruba, Ostrava, Czech Republic (R.H.) Helsinki University Hospital Comprehensive Cancer Center, University of Helsinki, Helsinki (K.P.) the Faculty of Medicine, Department of Hematology, University of Debrecen, Debrecen, Hungary (A.I.) Hadassah Medical Center, Jerusalem (D.L.) the Clinic of Hematology, Department of Internal Medicine, University of Genoa, and San Martino Hospital IRCCS - both in Genoa, Italy (R.M.L.) the Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan (K.Y.) the Department of Internal Medicine, Seoul National University College of Medicine (S.-S.Y.), and the Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine (J.-H.J.) - both in Seoul, South Korea the Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan (S.-P.Y.) the Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ondokuz Mayıs University, Samsun, Turkey (M.T.) and Abramson Cancer Center, University of Pennsylvania, Philadelphia (K.W.P.)
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Thirman, Michael J
Autor Thirman, Michael J From the Department of Leukemia, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (C.D.D., M.K.) the Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento (B.A.J.), the Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte (V. Pullarkat), and Genentech, South San Francisco (W.-J.H.) - all in California the Section of Hematology and Oncology, Department of Medicine, University of Chicago Medicine, Chicago (M.J.T.), and AbbVie, North Chicago (Y.Z., J.P.) - both in Illinois the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston (J.S.G., A.L.) the Australian Centre for Blood Diseases, Alfred Hospital and Monash University, Melbourne, VIC (A.H.W.) the Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany (H.D.) Hôpital St. Louis, Assistance Publique-Hôpitaux de Paris and Université de Paris, Paris (P.F.) the Third Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna (E.K.) the Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels (V.H.) the Department of Medicine, McMaster University, Hamilton, ON, Canada (B.L.) the Department of Hematology, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, Barcelona (J.E.) the Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China (J.W.) the Department of Hematology, University Hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Croatia (V. Pejsa) the Department of Clinic Subjects, University Hospital Ostrava-Poruba, Ostrava, Czech Republic (R.H.) Helsinki University Hospital Comprehensive Cancer Center, University of Helsinki, Helsinki (K.P.) the Faculty of Medicine, Department of Hematology, University of Debrecen, Debrecen, Hungary (A.I.) Hadassah Medical Center, Jerusalem (D.L.) the Clinic of Hematology, Department of Internal Medicine, University of Genoa, and San Martino Hospital IRCCS - both in Genoa, Italy (R.M.L.) the Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan (K.Y.) the Department of Internal Medicine, Seoul National University College of Medicine (S.-S.Y.), and the Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine (J.-H.J.) - both in Seoul, South Korea the Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan (S.-P.Y.) the Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ondokuz Mayıs University, Samsun, Turkey (M.T.) and Abramson Cancer Center, University of Pennsylvania, Philadelphia (K.W.P.)
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Garcia, Jacqueline S
Autor Garcia, Jacqueline S From the Department of Leukemia, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (C.D.D., M.K.) the Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento (B.A.J.), the Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte (V. Pullarkat), and Genentech, South San Francisco (W.-J.H.) - all in California the Section of Hematology and Oncology, Department of Medicine, University of Chicago Medicine, Chicago (M.J.T.), and AbbVie, North Chicago (Y.Z., J.P.) - both in Illinois the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston (J.S.G., A.L.) the Australian Centre for Blood Diseases, Alfred Hospital and Monash University, Melbourne, VIC (A.H.W.) the Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany (H.D.) Hôpital St. Louis, Assistance Publique-Hôpitaux de Paris and Université de Paris, Paris (P.F.) the Third Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna (E.K.) the Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels (V.H.) the Department of Medicine, McMaster University, Hamilton, ON, Canada (B.L.) the Department of Hematology, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, Barcelona (J.E.) the Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China (J.W.) the Department of Hematology, University Hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Croatia (V. Pejsa) the Department of Clinic Subjects, University Hospital Ostrava-Poruba, Ostrava, Czech Republic (R.H.) Helsinki University Hospital Comprehensive Cancer Center, University of Helsinki, Helsinki (K.P.) the Faculty of Medicine, Department of Hematology, University of Debrecen, Debrecen, Hungary (A.I.) Hadassah Medical Center, Jerusalem (D.L.) the Clinic of Hematology, Department of Internal Medicine, University of Genoa, and San Martino Hospital IRCCS - both in Genoa, Italy (R.M.L.) the Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan (K.Y.) the Department of Internal Medicine, Seoul National University College of Medicine (S.-S.Y.), and the Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine (J.-H.J.) - both in Seoul, South Korea the Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan (S.-P.Y.) the Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ondokuz Mayıs University, Samsun, Turkey (M.T.) and Abramson Cancer Center, University of Pennsylvania, Philadelphia (K.W.P.)
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Wei, Andrew H
Autor Wei, Andrew H From the Department of Leukemia, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (C.D.D., M.K.) the Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento (B.A.J.), the Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte (V. Pullarkat), and Genentech, South San Francisco (W.-J.H.) - all in California the Section of Hematology and Oncology, Department of Medicine, University of Chicago Medicine, Chicago (M.J.T.), and AbbVie, North Chicago (Y.Z., J.P.) - both in Illinois the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston (J.S.G., A.L.) the Australian Centre for Blood Diseases, Alfred Hospital and Monash University, Melbourne, VIC (A.H.W.) the Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany (H.D.) Hôpital St. Louis, Assistance Publique-Hôpitaux de Paris and Université de Paris, Paris (P.F.) the Third Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna (E.K.) the Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels (V.H.) the Department of Medicine, McMaster University, Hamilton, ON, Canada (B.L.) the Department of Hematology, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, Barcelona (J.E.) the Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China (J.W.) the Department of Hematology, University Hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Croatia (V. Pejsa) the Department of Clinic Subjects, University Hospital Ostrava-Poruba, Ostrava, Czech Republic (R.H.) Helsinki University Hospital Comprehensive Cancer Center, University of Helsinki, Helsinki (K.P.) the Faculty of Medicine, Department of Hematology, University of Debrecen, Debrecen, Hungary (A.I.) Hadassah Medical Center, Jerusalem (D.L.) the Clinic of Hematology, Department of Internal Medicine, University of Genoa, and San Martino Hospital IRCCS - both in Genoa, Italy (R.M.L.) the Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan (K.Y.) the Department of Internal Medicine, Seoul National University College of Medicine (S.-S.Y.), and the Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine (J.-H.J.) - both in Seoul, South Korea the Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan (S.-P.Y.) the Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ondokuz Mayıs University, Samsun, Turkey (M.T.) and Abramson Cancer Center, University of Pennsylvania, Philadelphia (K.W.P.)
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Konopleva, Marina
Autor Konopleva, Marina From the Department of Leukemia, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (C.D.D., M.K.) the Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento (B.A.J.), the Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte (V. Pullarkat), and Genentech, South San Francisco (W.-J.H.) - all in California the Section of Hematology and Oncology, Department of Medicine, University of Chicago Medicine, Chicago (M.J.T.), and AbbVie, North Chicago (Y.Z., J.P.) - both in Illinois the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston (J.S.G., A.L.) the Australian Centre for Blood Diseases, Alfred Hospital and Monash University, Melbourne, VIC (A.H.W.) the Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany (H.D.) Hôpital St. Louis, Assistance Publique-Hôpitaux de Paris and Université de Paris, Paris (P.F.) the Third Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna (E.K.) the Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels (V.H.) the Department of Medicine, McMaster University, Hamilton, ON, Canada (B.L.) the Department of Hematology, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, Barcelona (J.E.) the Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China (J.W.) the Department of Hematology, University Hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Croatia (V. Pejsa) the Department of Clinic Subjects, University Hospital Ostrava-Poruba, Ostrava, Czech Republic (R.H.) Helsinki University Hospital Comprehensive Cancer Center, University of Helsinki, Helsinki (K.P.) the Faculty of Medicine, Department of Hematology, University of Debrecen, Debrecen, Hungary (A.I.) Hadassah Medical Center, Jerusalem (D.L.) the Clinic of Hematology, Department of Internal Medicine, University of Genoa, and San Martino Hospital IRCCS - both in Genoa, Italy (R.M.L.) the Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan (K.Y.) the Department of Internal Medicine, Seoul National University College of Medicine (S.-S.Y.), and the Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine (J.-H.J.) - both in Seoul, South Korea the Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan (S.-P.Y.) the Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ondokuz Mayıs University, Samsun, Turkey (M.T.) and Abramson Cancer Center, University of Pennsylvania, Philadelphia (K.W.P.)
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Döhner, Hartmut
Autor Döhner, Hartmut From the Department of Leukemia, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (C.D.D., M.K.) the Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento (B.A.J.), the Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte (V. Pullarkat), and Genentech, South San Francisco (W.-J.H.) - all in California the Section of Hematology and Oncology, Department of Medicine, University of Chicago Medicine, Chicago (M.J.T.), and AbbVie, North Chicago (Y.Z., J.P.) - both in Illinois the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston (J.S.G., A.L.) the Australian Centre for Blood Diseases, Alfred Hospital and Monash University, Melbourne, VIC (A.H.W.) the Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany (H.D.) Hôpital St. Louis, Assistance Publique-Hôpitaux de Paris and Université de Paris, Paris (P.F.) the Third Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna (E.K.) the Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels (V.H.) the Department of Medicine, McMaster University, Hamilton, ON, Canada (B.L.) the Department of Hematology, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, Barcelona (J.E.) the Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China (J.W.) the Department of Hematology, University Hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Croatia (V. Pejsa) the Department of Clinic Subjects, University Hospital Ostrava-Poruba, Ostrava, Czech Republic (R.H.) Helsinki University Hospital Comprehensive Cancer Center, University of Helsinki, Helsinki (K.P.) the Faculty of Medicine, Department of Hematology, University of Debrecen, Debrecen, Hungary (A.I.) Hadassah Medical Center, Jerusalem (D.L.) the Clinic of Hematology, Department of Internal Medicine, University of Genoa, and San Martino Hospital IRCCS - both in Genoa, Italy (R.M.L.) the Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan (K.Y.) the Department of Internal Medicine, Seoul National University College of Medicine (S.-S.Y.), and the Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine (J.-H.J.) - both in Seoul, South Korea the Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan (S.-P.Y.) the Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ondokuz Mayıs University, Samsun, Turkey (M.T.) and Abramson Cancer Center, University of Pennsylvania, Philadelphia (K.W.P.)
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Letai, Anthony
Autor Letai, Anthony From the Department of Leukemia, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (C.D.D., M.K.) the Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento (B.A.J.), the Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte (V. Pullarkat), and Genentech, South San Francisco (W.-J.H.) - all in California the Section of Hematology and Oncology, Department of Medicine, University of Chicago Medicine, Chicago (M.J.T.), and AbbVie, North Chicago (Y.Z., J.P.) - both in Illinois the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston (J.S.G., A.L.) the Australian Centre for Blood Diseases, Alfred Hospital and Monash University, Melbourne, VIC (A.H.W.) the Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany (H.D.) Hôpital St. Louis, Assistance Publique-Hôpitaux de Paris and Université de Paris, Paris (P.F.) the Third Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna (E.K.) the Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels (V.H.) the Department of Medicine, McMaster University, Hamilton, ON, Canada (B.L.) the Department of Hematology, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, Barcelona (J.E.) the Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China (J.W.) the Department of Hematology, University Hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Croatia (V. Pejsa) the Department of Clinic Subjects, University Hospital Ostrava-Poruba, Ostrava, Czech Republic (R.H.) Helsinki University Hospital Comprehensive Cancer Center, University of Helsinki, Helsinki (K.P.) the Faculty of Medicine, Department of Hematology, University of Debrecen, Debrecen, Hungary (A.I.) Hadassah Medical Center, Jerusalem (D.L.) the Clinic of Hematology, Department of Internal Medicine, University of Genoa, and San Martino Hospital IRCCS - both in Genoa, Italy (R.M.L.) the Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan (K.Y.) the Department of Internal Medicine, Seoul National University College of Medicine (S.-S.Y.), and the Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine (J.-H.J.) - both in Seoul, South Korea the Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan (S.-P.Y.) the Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ondokuz Mayıs University, Samsun, Turkey (M.T.) and Abramson Cancer Center, University of Pennsylvania, Philadelphia (K.W.P.)
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Fenaux, Pierre
Autor Fenaux, Pierre From the Department of Leukemia, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (C.D.D., M.K.) the Department of Internal Medicine, Division of Hematology and Oncology, University of California Davis School of Medicine, Sacramento (B.A.J.), the Department of Hematology and Hematopoietic Cell Transplantation and Gehr Family Center for Leukemia Research, City of Hope Comprehensive Cancer Center, Duarte (V. Pullarkat), and Genentech, South San Francisco (W.-J.H.) - all in California the Section of Hematology and Oncology, Department of Medicine, University of Chicago Medicine, Chicago (M.J.T.), and AbbVie, North Chicago (Y.Z., J.P.) - both in Illinois the Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston (J.S.G., A.L.) the Australian Centre for Blood Diseases, Alfred Hospital and Monash University, Melbourne, VIC (A.H.W.) the Department of Internal Medicine III, Ulm University Hospital, Ulm, Germany (H.D.) Hôpital St. Louis, Assistance Publique-Hôpitaux de Paris and Université de Paris, Paris (P.F.) the Third Medical Department for Hematology and Oncology, Hanusch Hospital, Vienna (E.K.) the Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels (V.H.) the Department of Medicine, McMaster University, Hamilton, ON, Canada (B.L.) the Department of Hematology, Hospital Clinic, August Pi i Sunyer Biomedical Research Institute, Barcelona (J.E.) the Institute of Hematology and Hospital of Blood Disease, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin, China (J.W.) the Department of Hematology, University Hospital Dubrava, University of Zagreb School of Medicine, Zagreb, Croatia (V. Pejsa) the Department of Clinic Subjects, University Hospital Ostrava-Poruba, Ostrava, Czech Republic (R.H.) Helsinki University Hospital Comprehensive Cancer Center, University of Helsinki, Helsinki (K.P.) the Faculty of Medicine, Department of Hematology, University of Debrecen, Debrecen, Hungary (A.I.) Hadassah Medical Center, Jerusalem (D.L.) the Clinic of Hematology, Department of Internal Medicine, University of Genoa, and San Martino Hospital IRCCS - both in Genoa, Italy (R.M.L.) the Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan (K.Y.) the Department of Internal Medicine, Seoul National University College of Medicine (S.-S.Y.), and the Department of Hematology-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine (J.-H.J.) - both in Seoul, South Korea the Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan (S.-P.Y.) the Faculty of Medicine, Department of Internal Medicine, Division of Hematology, Ondokuz Mayıs University, Samsun, Turkey (M.T.) and Abramson Cancer Center, University of Pennsylvania, Philadelphia (K.W.P.)
NLK
ProQuest Central
od 1980-01-03 do Před 3 měsíci
Nursing & Allied Health Database (ProQuest)
od 1980-01-03 do Před 3 měsíci
Health & Medicine (ProQuest)
od 1980-01-03 do Před 3 měsíci
Family Health Database (ProQuest)
od 1980-01-03 do Před 3 měsíci
Psychology Database (ProQuest)
od 1980-01-03 do Před 3 měsíci
Health Management Database (ProQuest)
od 1980-01-03 do Před 3 měsíci
Public Health Database (ProQuest)
od 1980-01-03 do Před 3 měsíci
PubMed
32786187
DOI
10.1056/nejmoa2012971
Knihovny.cz E-zdroje
BACKGROUND: Older patients with acute myeloid leukemia (AML) have a dismal prognosis, even after treatment with a hypomethylating agent. Azacitidine added to venetoclax had promising efficacy in a previous phase 1b study. METHODS: We randomly assigned previously untreated patients with confirmed AML who were ineligible for standard induction therapy because of coexisting conditions, because they were 75 years of age or older, or both to azacitidine plus either venetoclax or placebo. All patients received a standard dose of azacitidine (75 mg per square meter of body-surface area subcutaneously or intravenously on days 1 through 7 every 28-day cycle); venetoclax (target dose, 400 mg) or matching placebo was administered orally, once daily, in 28-day cycles. The primary end point was overall survival. RESULTS: The intention-to-treat population included 431 patients (286 in the azacitidine-venetoclax group and 145 in the azacitidine-placebo [control] group). The median age was 76 years in both groups (range, 49 to 91). At a median follow-up of 20.5 months, the median overall survival was 14.7 months in the azacitidine-venetoclax group and 9.6 months in the control group (hazard ratio for death, 0.66; 95% confidence interval, 0.52 to 0.85; P<0.001). The incidence of complete remission was higher with azacitidine-venetoclax than with the control regimen (36.7% vs. 17.9%; P<0.001), as was the composite complete remission (complete remission or complete remission with incomplete hematologic recovery) (66.4% vs. 28.3%; P<0.001). Key adverse events included nausea of any grade (in 44% of the patients in the azacitidine-venetoclax group and 35% of those in the control group) and grade 3 or higher thrombocytopenia (in 45% and 38%, respectively), neutropenia (in 42% and 28%), and febrile neutropenia (in 42% and 19%). Infections of any grade occurred in 85% of the patients in the azacitidine-venetoclax group and 67% of those in the control group, and serious adverse events occurred in 83% and 73%, respectively. CONCLUSIONS: In previously untreated patients who were ineligible for intensive chemotherapy, overall survival was longer and the incidence of remission was higher among patients who received azacitidine plus venetoclax than among those who received azacitidine alone. The incidence of febrile neutropenia was higher in the venetoclax-azacitidine group than in the control group. (Funded by AbbVie and Genentech; VIALE-A ClinicalTrials.gov number, NCT02993523.).
- MeSH
- akutní myeloidní leukemie farmakoterapie mortalita MeSH
- analýza podle původního léčebného záměru MeSH
- azacytidin aplikace a dávkování škodlivé účinky MeSH
- bicyklické sloučeniny heterocyklické aplikace a dávkování škodlivé účinky MeSH
- dvojitá slepá metoda MeSH
- indukce remise MeSH
- Kaplanův-Meierův odhad MeSH
- leukopenie chemicky indukované MeSH
- lidé středního věku MeSH
- lidé MeSH
- následné studie MeSH
- pneumonie etiologie MeSH
- protokoly antitumorózní kombinované chemoterapie terapeutické užití MeSH
- recidiva MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- sulfonamidy aplikace a dávkování škodlivé účinky MeSH
- trombocytopenie chemicky indukované MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky, fáze III MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
- srovnávací studie MeSH
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