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Different Grey Matter Microstructural Patterns in Cognitively Healthy Versus Typical Ageing Healthy Versus Typical Brain Ageing

Filip, Pavel
Author Authority ORCID Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, Minnesota, USA Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic Department of Cybernetics, Czech Technical University in Prague, Prague, Czech Republic
McCarten, J Riley
Author McCarten, J Riley Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA Department of Neurology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Hemmy, Laura
Author Hemmy, Laura Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA Department of Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Crocker, Jillian
Author Crocker, Jillian Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, Minnesota, USA
Wolf, Michael
Author Wolf, Michael Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, Minnesota, USA
Thotland, Jeromy
Author Thotland, Jeromy Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, Minnesota, USA
Cayci, Zuzan
Author Cayci, Zuzan Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA
Michaeli, Shalom
Author Michaeli, Shalom Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, Minnesota, USA
Eberly, Lynn E
Author Eberly, Lynn E Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, Minnesota, USA Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
Terpstra, Melissa
Author Terpstra, Melissa Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, Minnesota, USA

NMR in biomedicine. 2025 ; 38 (1) : e5305. [pub] -

NMR Biomed
ISSN 1099-1492
Medvik
Source

Ageing is a complex phenomenon affecting a wide range of coexisting biological processes. The homogeneity of the studied population is an essential parameter for valid interpretations of outcomes. The presented study capitalises on the MRI data available in the Human Connectome Project-Aging (HCP-A) and, within individuals over 55 years of age who passed the HCP-A section criteria, compares a subgroup of 37 apparently neurocognitively healthy individuals selected based on stringent criteria with 37 age and sex-matched individuals still representative of typical ageing but who did not pass the stringent definition of neurocognitively healthy. Specifically, structural scans, diffusion weighted imaging and T1w/T2w ratio were utilised. Furthermore, data of 26 HCP-A participants older than 90 years as notional 'super-agers' were analysed. The relationship of age and several microstructural MRI metrics (T1w/T2w ratio, mean diffusivity, intracellular volume fraction and free water volume fraction) differed significantly between typical and healthy ageing cohort in areas highly relevant for ageing such as hippocampus, prefrontal and temporal cortex and cerebellum. However, the trajectories of the healthy ageing population did not show substantially better overlap with the findings in people older than 90 than those of the typical population. Therefore, caution must be exercised in the choice of adequate study group characteristics relevant for respective ageing-related hypotheses. Contrary to typical ageing group, the healthy ageing cohort may show generally stable levels of several MRI metrics of interest.

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