V rámci biologického monitoringu byly v roce 2005 sledovány hladiny kadmia, olova, rtuti, mìdi, selenu a zinku v krvi a moèi dospìlé populace. Koncentrace kadmia v krvi kuøákù (medián) byla vyšší než u nekuøákù (1,30 vs. 0,50 μg/l). U žen byly nalezeny vyšší koncentrace kadmia v moèi ve srovnání s muži, u obou pohlaví byl pozorován vzestup hladin kadmia v moèi s vìkem. Koncentrace olova v krvi byly vyšší u mužù (35,4 μg/l) než u žen (26,6 μg/l) a stoupaly s vìkem. Koncentrace rtuti v krvi u mužù a žen byly 0,91 a 1,16 μg/l. Hladina selenu v krvi dospìlých byla 111 μg/l, hodnoty mìdi a zinku v krvi byly v normì a stabilizované. Muži mìli významnì nižší koncentrace mìdi v krvi ve srovnání se ženami neužívajícími a užívajícími orální antikoncepci (870 vs. 950 vs. 1305 μg/l).

In 2005 the concentrations of trace elements (cadmium, lead, mercury, copper, selenium, zinc) in blood and urine of adults were measured in the framework of the Biological Monitoring Project in the Czech Republic. Blood cadmium levels in adults were significantly influenced by smoking (medians 1.30 and 0.50 μg/l in smokers and non-smokers, respectively). The levels of cadmium in urine were higher in women than in men. Higher blood lead levels were observed in men (35,4 μg/l) in comparison to women (26,6 μg/l), plumbemia correlated with age. Blood mercury levels were 0.91 and 1.16 μg/l in men and women, respectively. Blood selenium levels were 111 μg/l. Blood copper and zinc levels are stabilized. Significantly lower blood copper levels were found in men in comparison with female non-users and users of oral contraception (870, 950 and 1305 μg/l, respectively).

• MeSH
• kadmium krev   moč   MeSH
• kontraceptiva orální MeSH
• lidé MeSH
• měď krev   moč   MeSH
• olovo krev   moč   MeSH
• poruchy vyvolané užíváním tabáku MeSH
• referenční hodnoty MeSH
• rozložení podle pohlaví MeSH
• rtuť krev   moč   MeSH
• selen krev   moč   MeSH
• vystavení vlivu životního prostředí MeSH
• xenobiotika krev   moč   MeSH
• zinek krev   moč   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH

• Publikační typ
• abstrakty MeSH

The Human Biological Monitoring (HBM) project was launched in the Czech Republic in 1994 as a part of the nation-wide Environmental Health Monitoring System to assess the exposure of the Czech general population to a broad spectrum of environmental contaminants. Over the years 2001-2003, the concentrations of lead (Pb), cadmium (Cd), and mercury (Hg) were determined in whole blood of 1188 adults (blood donors) and 333 children and in urine of 657 adults and 619 children. In adults, the median blood lead (B-Pb) level was 33microg/l. Men had higher B-Pb levels than women (medians 37microg/l vs. 25microg/l). Significantly higher B-Pb levels were observed in smokers compared to non-smokers (36microg/l vs. 31microg/l). In children, no sex-dependent differences were observed (median 31microg/l). In total, the median blood Cd level (B-Cd) in adults was 0.5microg/l. Smokers showed a median B-Cd level about 3 times as high as non-smokers (1.3microg/l vs. 0.40microg/l). Neither sex- nor age-related differences were observed in B-Cd levels. In 65% of children, B-Cd levels were below the limit of detection (LOD). The overall median urinary cadmium level (U-Cd) in adults was 0.31microg/g creatinine. Significantly higher U-Cd levels were found in women (median 0.39microg/g creatinine) compared to men (0.29microg/g creatinine). No significant differences were found between smokers and non-smokers. In more than 50% of children, the U-Cd level was below the LOD (=0.2microg/l). The median blood mercury (B-Hg) level in adults was 0.89microg/l. Significant differences were found between smokers (0.80microg/l) and non-smokers (0.92microg/l), and between men and women (0.86microg/l vs. 0.94microg/l). The median B-Hg level in children was 0.42microg/l and no sex-related differences were observed. The median urinary mercury (U-Hg) levels were 0.63microg/g creatinine in adults and 0.37microg/g creatinine in children. Significantly higher U-Hg levels were obtained in women and non-smokers compared to men and smokers, respectively. The B-Pb, B-Hg, U-Cd, and U-Hg levels significantly correlated with age. The following reference values were recommended for the period 2001-2003: 80, 65 and 55microg/l for B-Pb and 3.1, 4.0 and 1.5microg/l for B-Hg in men, women and children, respectively; 1.1microg/l and 1.2microg/g creatinine for B-Cd and U-Cd, respectively, in adult non-smokers; 5.4 and 12.0microg/g creatinine for U-Hg in men and women, respectively, and 3.7 and 5.5microg/g creatinine for U-Hg in boys and girls, respectively. The previous reference values for B-Pb and B-Cd needed revision and were reduced.

• MeSH
• dítě MeSH
• dospělí MeSH
• financování organizované MeSH
• kadmium krev   moč   MeSH
• lidé středního věku MeSH
• mladiství MeSH
• monitorování životního prostředí MeSH
• olovo krev   MeSH
• referenční hodnoty MeSH
• rtuť krev   moč   MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• lidé středního věku MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH

• MeSH
• dospělí MeSH
• epidemiologické studie MeSH
• finanční podpora výzkumu jako téma MeSH
• křečci praví MeSH
• populační charakteristiky MeSH
• referenční standardy MeSH
• sběr dat MeSH
• selen krev   MeSH
• Check Tag
• dospělí MeSH
• křečci praví MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Geografické názvy
• Česká republika MeSH