Antitumour efficiency of combined therapy with N-9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP) and docetaxel (DTX) was studied in an in vivo model of s.c. transplanted Sprague-Dawley (SD/Cub) rat T-cell lymphoma (phenotype SD10/96). The effect of the combined treatment of DTX with PMEDAP was significantly higher than that of DTX or PMEDAP alone. The s.c. administration of DXT into the vicinity of growing lymphoma together with i.p. administration of PMEDAP was found to be the most efficient combination. In this case, two out of four rats did not develop any lymphoma and remained alive. An irregular expression of Bcl2 protein was found in untreated and treated lymphomas, while the expression of protein p53 as well as MDM2 was not observed. All three types of the above-mentioned treatments (PMEDAP, DXT, DXT+PMEDAP) increased significantly the number of p21-positive cells, compared with untreated tumours.
- MeSH
- adenin analogy a deriváty aplikace a dávkování MeSH
- fytogenní protinádorové látky aplikace a dávkování farmakologie krev MeSH
- injekce intraperitoneální MeSH
- injekce subkutánní MeSH
- krysa rodu rattus MeSH
- lymfom T-buněčný * farmakoterapie MeSH
- modely nemocí na zvířatech MeSH
- paclitaxel analogy a deriváty aplikace a dávkování farmakologie krev MeSH
- potkani Sprague-Dawley MeSH
- protokoly protinádorové kombinované chemoterapie * farmakologie MeSH
- synergismus léků MeSH
- taxoidy * MeSH
- transplantace nádorů MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
- MeSH
- adenin analogy a deriváty aplikace a dávkování MeSH
- fytogenní protinádorové látky aplikace a dávkování farmakologie krev MeSH
- krysa rodu rattus MeSH
- lymfom T-buněčný farmakoterapie MeSH
- paclitaxel aplikace a dávkování farmakologie krev MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
