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1. Autor: Schultz, R. L

1 záznamů v Medvik Filtry

Článek

Metabolic adaptations of skeletal muscle to voluntary wheel running exercise in hypertensive heart failure rats

Schultz, R. L
Autor Schultz, R. L Department of Biology, University of South Dakota, Vermillion, SD, USA University of Sioux Falls, Sioux Falls, SD, USA,
Kullman, E. L
Autor Kullman, E. L Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA Department of Nutrition, Case Western Reserve University, School of Medicine, Cleveland, OH, USA
Waters, R. P
Autor Waters, R. P Department of Biology, University of South Dakota, Vermillion, SD, USA
Huang, H
Autor Huang, H Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA
Kirwan, J. P
Autor Kirwan, J. P Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA Metabolic Translational Research Center, Endocrinology and Metabolism Institute, Cleveland Clinic, Cleveland, OH, USA Department of Nutrition, Case Western Reserve University, School of Medicine, Cleveland, OH, USA Department of Physiology, Case Western Reserve University, School of Medicine, Cleveland, OH, USA
Gerdes, A. M
Autor Gerdes, A. M Department of Biological Sciences, New York College of Osteopathic Medicine at New York Institute of Technology, Old Westbury, NY, USA
Swallow, J. G
Autor Swallow, J. G Department of Biology, University of South Dakota, Vermillion, SD, USA Department of Integrative Biology, University of Colorado Denver, Denver, CO, USA

Physiological research. 2013 ; 62 (4) : 361-369.

Physiol. Res. (Print)
ISSN 1802-9973
Medvik
Zdroj

The Spontaneously Hypertensive Heart Failure (SHHF) rat mimics the human progression of hypertension from hypertrophy to heart failure. However, it is unknown whether SHHF animals can exercise at sufficient levels to observe beneficial biochemical adaptations in skeletal muscle. Thirty-seven female SHHF and Wistar-Furth (WF) rats were randomized to sedentary (SHHFsed and WFsed) and exercise groups (SHHFex and WFex). The exercise groups had access to running wheels from 6-22 months of age. Hindlimb muscles were obtained for metabolic measures that included mitochondrial enzyme function and expression, and glycogen utilization. The SHHFex rats ran a greater distance and duration as compared to the WFex rats (P<0.05), but the WFex rats ran at a faster speed (P<0.05). Skeletal muscle citrate synthase and beta-hydroxyacyl-CoA dehydrogenase enzyme activity was not altered in the SHHFex group, but was increased (P<0.05) in the WFex animals. Citrate synthase protein and gene expression were unchanged in SHHFex animals, but were increased in WFex rats (P<0.05). In the WFex animals muscle glycogen was significantly depleted after exercise (P<0.05), but not in the SHHFex group. We conclude that despite robust amounts of aerobic activity, voluntary wheel running exercise was not sufficiently intense to improve the oxidative capacity of skeletal muscle in adult SHHF animals, indicating an inability to compensate for declining heart function by improving peripheral oxidative adaptations in the skeletal muscle.

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