• Klíčová slova
• séropozitivita,
• MeSH
• antagonisté dopaminu terapeutické užití   MeSH
• dítě MeSH
• dopamin analýza   MeSH
• elektroencefalografie MeSH
• ELISA MeSH
• koktavost * etiologie   imunologie   patologie   MeSH
• lebka diagnostické zobrazování   MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• mladiství MeSH
• předškolní dítě MeSH
• protilátky imunologie   MeSH
• sérum imunologie   MeSH
• statistika jako téma MeSH
• Toxoplasma * imunologie   patogenita   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• předškolní dítě MeSH
• Publikační typ
• časopisecké články MeSH

The aim of the present study was to investigate the association between various clinical aspects of schizophrenia and seropositivity against Toxoplasma gondii (Nicolle et Manceaux, 1908). We selected 94 patients with schizophrenia and investigated the seropositivity rate for anti-T. gondii IgG antibodies by ELISA. Clinical parameters of schizophrenic patients such as illness type and status, clinical course, awareness of the illness and need for electroconvulsive therapy (ECT) were compared with their serological status. Anti-T. gondii IgG antibodies were detected in 43 (46%) of schizophrenic patients. Chronic patients had a rate of 34 (72%) seropositivity, whereas 9 (22%) of the patients with partial remission showed evidence of latent toxoplasmosis. Of continuous patients, 35 (81%) were found to be seropositive and this rate was significantly more than in the other groups. The rate of latent toxoplasmosis was detected significantly higher in patients who lack awareness of schizophrenia (36, i.e. 72%) than the patients who were aware of their illnesses (7, i.e. 16%). Anti-T. gondii IgG antibodies were detected in 38 (70%) of ECT performed patients while this percentage was 13% in the ones who had never been treated with ECT. This difference was also statistically significant. We showed that Toxoplasma-infected subjects had 15× higher probability of having continuous course of disease than Toxoplasma-free subjects. Our results put forth the possibility of latent toxoplasmosis to have a negative impact on the course of schizophrenia and treatment response of schizophrenic patients.

• Klíčová slova
• séropozitivita,
• MeSH
• latentní infekce etiologie   imunologie   komplikace   MeSH
• lidé MeSH
• prognóza MeSH
• schizofrenie * imunologie   klasifikace   krev   patofyziologie   MeSH
• statistika jako téma MeSH
• Toxoplasma imunologie   patogenita   MeSH
• toxoplazmóza * etiologie   imunologie   komplikace   MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH