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Autor
Alroughani, Raed 4 Berger, Eric 4 Bourre, Bertrand 4 Boz, Cavit 4 Butzkueven, Helmut 4 Cabre, Philippe 4 Casey, Romain 4 Ciron, Jonathan 4 Clavelou, Pierre 4 Csepany, Tunde 4 Debouverie, Marc 4 Edan, Gilles 4 Girard, Marc 4 Gout, Olivier 4 Grammond, Pierre 4 Heinzlef, Olivier 4 Horakova, Dana 4 Izquierdo, Guillermo 4 Kalincik, Tomas 4 Labauge, Pierre 4
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Pracoviště
Division of Neurology Department of M... 4 Dokuz Eylul University Konak Izmir Tu... 4 Haydarpasa Numune Training and Resear... 4 KTU Medical Faculty Farabi Hospital T... 4 Medical Faculty 19 Mayis University S... 4 Central Clinical School Monash Univer... 3 Department of Basic Medical Sciences ... 3 Department of Neurology Faculty of Me... 3 Department of Neurology John Hunter H... 3 Department of Neurology The Alfred Ho... 3 Department of Neurology and Center of... 3 Department of Neuroscience Azienda Os... 3 Department of Neuroscience Imaging an... 3 Hospital Universitario Virgen Macaren... 3 Nehme and Therese Tohme Multiple Scle... 3 Rehabilitation and MS Centre Overpelt... 3 Azienda Ospedaliera di Rilievo Nazion... 2 Bakirkoy Education and Research Hospi... 2 CHU La Milétrie Hôpital Jean Bernard ... 2 CHU de Besançon Service de Neurologie... 2
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Autor
Alroughani, Raed 4 Berger, Eric 4 Bourre, Bertrand 4 Boz, Cavit 4 Butzkueven, Helmut 4 Cabre, Philippe 4 Casey, Romain 4 Ciron, Jonathan 4 Clavelou, Pierre 4 Csepany, Tunde 4 Debouverie, Marc 4 Edan, Gilles 4 Girard, Marc 4 Gout, Olivier 4 Grammond, Pierre 4 Heinzlef, Olivier 4 Horakova, Dana 4 Izquierdo, Guillermo 4 Kalincik, Tomas 4 Labauge, Pierre 4
- Organizace
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Pracoviště
Division of Neurology Department of M... 4 Dokuz Eylul University Konak Izmir Tu... 4 Haydarpasa Numune Training and Resear... 4 KTU Medical Faculty Farabi Hospital T... 4 Medical Faculty 19 Mayis University S... 4 Central Clinical School Monash Univer... 3 Department of Basic Medical Sciences ... 3 Department of Neurology Faculty of Me... 3 Department of Neurology John Hunter H... 3 Department of Neurology The Alfred Ho... 3 Department of Neurology and Center of... 3 Department of Neuroscience Azienda Os... 3 Department of Neuroscience Imaging an... 3 Hospital Universitario Virgen Macaren... 3 Nehme and Therese Tohme Multiple Scle... 3 Rehabilitation and MS Centre Overpelt... 3 Azienda Ospedaliera di Rilievo Nazion... 2 Bakirkoy Education and Research Hospi... 2 CHU La Milétrie Hôpital Jean Bernard ... 2 CHU de Besançon Service de Neurologie... 2
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Roos, Izanne
Autor Roos, Izanne ORCID From the CORe (I.R., C.M., T.K.), Department of Medicine, University of Melbourne, Australia Melbourne MS Centre (I.R., C.M., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia Rennes, University (E.L.), EHESP, REPERES EA 7449, France Univ Rennes (E.L.), CHU Rennes, Inserm, CIC 1414 ([Centre d'Investigation Clinique de Rennes]), France Université de Lyon (R.C.), Université Claude Bernard Lyon 1, France Hospices Civils de Lyon (R.C.), Service de Neurologie, Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Bron, France Observatoire Français de La Sclérose en Plaques (R.C.), Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, France Eugène Devic EDMUS Foundation Against Multiple Sclerosis (R.C.), State-approved Foundation, Bron, France Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic Nancy University Hospital (M.D.), Department of Neurology, Nancy, France Université de Lorraine (M.D.), APEMAC, Nancy, France Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania, Italy Multiple Sclerosis Center (F.P.), University of Catania, Italy CHU de Strasbourg (J.D.S.), Department of Neurology and Clinical Investigation Center, CIC 1434, INSERM 1434, Strasbourg, France Hospital Universitario Virgen Macarena (G.I., S.E.), Sevilla, Spain CHU Pontchaillou (G.E.), CIC1414 INSERM, Rennes, France CHUM MS Center and Universite de Montreal (A.P., M.G.), Canada Dokuz Eylul University (S.O.), Konak/Izmir, Turkey CISSS Chaudière-Appalache (P.G.), Levis, Canada CHU Lille (H.Z.), CRCSEP Lille, Univ Lille, U1172, France CHU de Toulouse (J.C.), Hôpital Pierre-Paul Riquet, Department of Neurology, CRC-SEP, France Département de Neurologie (E.M.), Hôpital Pitié-Salpêtrière, APHP, Paris CHU de Dijon (T.M.), Department of Neurology, EA4184, France Department NEUROFARBA (M.P.A.), University of Florence, Italy CHU de Montpellier (P.L.), MS Unit, France University of Montpellier (MUSE) (P.L.), France Division of Neurology (Raed Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait Department of Neurology (K.B., O.S.), Box Hill Hospital, Melbourne, Australia Monash University (K.B., O.S.), Melbourne, Australia Melbourne MS Centre (K.B.), Royal Melbourne Hospital, Australia The Alfred Hospital (O.S.), Melbourne, Australia Medical Faculty (M.T.), 19 Mayis University, Samsun, Turkey CHU de Nantes (D.A.L.), Service de Neurologie & CIC015 INSERM, France CRTI-Inserm U1064 (D.A.L.), Nantes, France CHU de Besançon (E.B.), Service de Neurologie 25 030 Besançon, France Neuro Rive-Sud (F.G.M.), Quebec, Canada Neurology (C.L.-F.), UR2CA, Centre Hospitalier Universitaire Pasteur2, Université Nice Côte d'Azur, Nice, France UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy KTU Medical Faculty Farabi Hospital (C.B.), Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle, Australia Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia CHU Clermont-Ferrand (Pierre Clavelou), Department of Neurology Université Clermont Auvergne, Inserm, Neuro-Dol, Clermont-Ferrand, France Sorbonne Universités (B.S.), UPMC Paris 06, Brain and Spine Institute, ICM, Hôpital de La Pitié Salpêtrière, Inserm UMR S 1127, CNRS UMR 7225, and Department of Neurology, AP-HP, Saint-Antoine Hospital, Paris, France CSSS Saint-Jérôme (Julie Prevost), Saint-Jerome, Canada Neurologic Clinic and Policlinic (L.K.), Departments of Medicine and Clinical Research, University Hospital and University of Basel, Switzerland Aix Marseille Univ (Jean Pelletier), APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, France Isfahan University of Medical Sciences (V.S.), Iran Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y., S.J.K.), American University of Beirut Medical Center, Beirut, Lebanon Department of Neurology (Oliver Gerlach), Zuyderland Medical Center, Sittard-Geleen, Netherlands Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy Cliniques Universitaires Saint-Luc (V.V.P.), Université Catholique de Louvain, Brussels, Belgium Fondation Rotschild (Olivier Gout), Department of Neurology, Paris, France Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Hôpital de Poissy (O.H.), Department of Neurology, France Department of Neurology (E.T.), Nimes University Hospital, France Institut de Génomique Fonctionnelle (E.T.), UMR5203, INSERM 1191, Univ. Montpellier, France University of Queensland (P.A.M.), Brisbane, Australia Royal Brisbane and Women's Hospital (P.A.M.), Australia Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey CHU de Rouen (B.B.), Department of Neurology, France Flinders University (M.S.), Adelaide, Australia Instituto de Investigación Sanitaria Biodonostia (T.C.-T.), Hospital Universitario Donostia, San Sebastián, Spain CHU de Reims (S.B.), Department of Neurology, France Nemocnice Jihlava (Radek Ampapa), Czech Republic Monash Medical Centre (E.G.B.), Melbourne, Australia APHP (A.W.), Hôpital Henri Mondor, Department of Neurology, Créteil, France Austin Health (R.A.M.), Melbourne, Australia University Hospital Reina Sofia (E.A.-M.), Cordoba, Spain CHU de La Martinique (Philippe Cabre), Department of Neurology, Fort-de-France, France Hôpital Sud Francilien (N.H.B.), Department of Neurology, Corbeil Essonnes, France Department of Neurology (A.V.W., H.B.), The Alfred Hospital, Melbourne, Australia Central Clinical School (A.V.W., H.B.), Monash University, Melbourne, Australia Department of Neurology (G.L., L.V.H.), University Hospital Ghent, Belgium Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain CHU La Milétrie (N.M.), Hôpital Jean Bernard, Department of Neurology, Poitiers, France Liverpool Hospital (S.H.), Sydney, Australia Hospital de Galdakao-Usansolo (J.L.S.-M.), Spain Brain and Mind Centre (M.H.B.), Sydney, Australia CHU Bicêtre (C.L.), Department of Neurology, F-94275 Le Kremlin Bicêtre, France Westmead Hospital (Steve Vucic), Sydney, Australia Department of Neurology (Y.S., R.G.), Razi Hospital, Manouba, Tunisia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Hospital Universitari MútuaTerrassa (J.S.), Barcelona, Spain Groene Hart Ziekenhuis (K.G.), Gouda, Netherlands Sultan Qaboos University Hospital (A.A.-A.), Al-Khodh, Oman Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil Service de Neurologie (Sandra Vukusic), Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France Centre des Neurosciences de Lyon (Sandra Vukusic), Observatoire Français de La Sclérose en Plaques, INSERM 1028 et CNRS UMR5292, France and Université Claude Bernard Lyon 1 (Sandra Vukusic), Faculté de Médecine Lyon Est, France
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Malpas, Charles
Autor Malpas, Charles From the CORe (I.R., C.M., T.K.), Department of Medicine, University of Melbourne, Australia Melbourne MS Centre (I.R., C.M., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia Rennes, University (E.L.), EHESP, REPERES EA 7449, France Univ Rennes (E.L.), CHU Rennes, Inserm, CIC 1414 ([Centre d'Investigation Clinique de Rennes]), France Université de Lyon (R.C.), Université Claude Bernard Lyon 1, France Hospices Civils de Lyon (R.C.), Service de Neurologie, Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Bron, France Observatoire Français de La Sclérose en Plaques (R.C.), Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, France Eugène Devic EDMUS Foundation Against Multiple Sclerosis (R.C.), State-approved Foundation, Bron, France Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic Nancy University Hospital (M.D.), Department of Neurology, Nancy, France Université de Lorraine (M.D.), APEMAC, Nancy, France Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania, Italy Multiple Sclerosis Center (F.P.), University of Catania, Italy CHU de Strasbourg (J.D.S.), Department of Neurology and Clinical Investigation Center, CIC 1434, INSERM 1434, Strasbourg, France Hospital Universitario Virgen Macarena (G.I., S.E.), Sevilla, Spain CHU Pontchaillou (G.E.), CIC1414 INSERM, Rennes, France CHUM MS Center and Universite de Montreal (A.P., M.G.), Canada Dokuz Eylul University (S.O.), Konak/Izmir, Turkey CISSS Chaudière-Appalache (P.G.), Levis, Canada CHU Lille (H.Z.), CRCSEP Lille, Univ Lille, U1172, France CHU de Toulouse (J.C.), Hôpital Pierre-Paul Riquet, Department of Neurology, CRC-SEP, France Département de Neurologie (E.M.), Hôpital Pitié-Salpêtrière, APHP, Paris CHU de Dijon (T.M.), Department of Neurology, EA4184, France Department NEUROFARBA (M.P.A.), University of Florence, Italy CHU de Montpellier (P.L.), MS Unit, France University of Montpellier (MUSE) (P.L.), France Division of Neurology (Raed Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait Department of Neurology (K.B., O.S.), Box Hill Hospital, Melbourne, Australia Monash University (K.B., O.S.), Melbourne, Australia Melbourne MS Centre (K.B.), Royal Melbourne Hospital, Australia The Alfred Hospital (O.S.), Melbourne, Australia Medical Faculty (M.T.), 19 Mayis University, Samsun, Turkey CHU de Nantes (D.A.L.), Service de Neurologie & CIC015 INSERM, France CRTI-Inserm U1064 (D.A.L.), Nantes, France CHU de Besançon (E.B.), Service de Neurologie 25 030 Besançon, France Neuro Rive-Sud (F.G.M.), Quebec, Canada Neurology (C.L.-F.), UR2CA, Centre Hospitalier Universitaire Pasteur2, Université Nice Côte d'Azur, Nice, France UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy KTU Medical Faculty Farabi Hospital (C.B.), Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle, Australia Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia CHU Clermont-Ferrand (Pierre Clavelou), Department of Neurology Université Clermont Auvergne, Inserm, Neuro-Dol, Clermont-Ferrand, France Sorbonne Universités (B.S.), UPMC Paris 06, Brain and Spine Institute, ICM, Hôpital de La Pitié Salpêtrière, Inserm UMR S 1127, CNRS UMR 7225, and Department of Neurology, AP-HP, Saint-Antoine Hospital, Paris, France CSSS Saint-Jérôme (Julie Prevost), Saint-Jerome, Canada Neurologic Clinic and Policlinic (L.K.), Departments of Medicine and Clinical Research, University Hospital and University of Basel, Switzerland Aix Marseille Univ (Jean Pelletier), APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, France Isfahan University of Medical Sciences (V.S.), Iran Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y., S.J.K.), American University of Beirut Medical Center, Beirut, Lebanon Department of Neurology (Oliver Gerlach), Zuyderland Medical Center, Sittard-Geleen, Netherlands Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy Cliniques Universitaires Saint-Luc (V.V.P.), Université Catholique de Louvain, Brussels, Belgium Fondation Rotschild (Olivier Gout), Department of Neurology, Paris, France Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Hôpital de Poissy (O.H.), Department of Neurology, France Department of Neurology (E.T.), Nimes University Hospital, France Institut de Génomique Fonctionnelle (E.T.), UMR5203, INSERM 1191, Univ. Montpellier, France University of Queensland (P.A.M.), Brisbane, Australia Royal Brisbane and Women's Hospital (P.A.M.), Australia Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey CHU de Rouen (B.B.), Department of Neurology, France Flinders University (M.S.), Adelaide, Australia Instituto de Investigación Sanitaria Biodonostia (T.C.-T.), Hospital Universitario Donostia, San Sebastián, Spain CHU de Reims (S.B.), Department of Neurology, France Nemocnice Jihlava (Radek Ampapa), Czech Republic Monash Medical Centre (E.G.B.), Melbourne, Australia APHP (A.W.), Hôpital Henri Mondor, Department of Neurology, Créteil, France Austin Health (R.A.M.), Melbourne, Australia University Hospital Reina Sofia (E.A.-M.), Cordoba, Spain CHU de La Martinique (Philippe Cabre), Department of Neurology, Fort-de-France, France Hôpital Sud Francilien (N.H.B.), Department of Neurology, Corbeil Essonnes, France Department of Neurology (A.V.W., H.B.), The Alfred Hospital, Melbourne, Australia Central Clinical School (A.V.W., H.B.), Monash University, Melbourne, Australia Department of Neurology (G.L., L.V.H.), University Hospital Ghent, Belgium Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain CHU La Milétrie (N.M.), Hôpital Jean Bernard, Department of Neurology, Poitiers, France Liverpool Hospital (S.H.), Sydney, Australia Hospital de Galdakao-Usansolo (J.L.S.-M.), Spain Brain and Mind Centre (M.H.B.), Sydney, Australia CHU Bicêtre (C.L.), Department of Neurology, F-94275 Le Kremlin Bicêtre, France Westmead Hospital (Steve Vucic), Sydney, Australia Department of Neurology (Y.S., R.G.), Razi Hospital, Manouba, Tunisia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Hospital Universitari MútuaTerrassa (J.S.), Barcelona, Spain Groene Hart Ziekenhuis (K.G.), Gouda, Netherlands Sultan Qaboos University Hospital (A.A.-A.), Al-Khodh, Oman Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil Service de Neurologie (Sandra Vukusic), Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France Centre des Neurosciences de Lyon (Sandra Vukusic), Observatoire Français de La Sclérose en Plaques, INSERM 1028 et CNRS UMR5292, France and Université Claude Bernard Lyon 1 (Sandra Vukusic), Faculté de Médecine Lyon Est, France
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Leray, Emmanuelle
Autor Leray, Emmanuelle From the CORe (I.R., C.M., T.K.), Department of Medicine, University of Melbourne, Australia Melbourne MS Centre (I.R., C.M., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia Rennes, University (E.L.), EHESP, REPERES EA 7449, France Univ Rennes (E.L.), CHU Rennes, Inserm, CIC 1414 ([Centre d'Investigation Clinique de Rennes]), France Université de Lyon (R.C.), Université Claude Bernard Lyon 1, France Hospices Civils de Lyon (R.C.), Service de Neurologie, Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Bron, France Observatoire Français de La Sclérose en Plaques (R.C.), Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, France Eugène Devic EDMUS Foundation Against Multiple Sclerosis (R.C.), State-approved Foundation, Bron, France Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic Nancy University Hospital (M.D.), Department of Neurology, Nancy, France Université de Lorraine (M.D.), APEMAC, Nancy, France Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania, Italy Multiple Sclerosis Center (F.P.), University of Catania, Italy CHU de Strasbourg (J.D.S.), Department of Neurology and Clinical Investigation Center, CIC 1434, INSERM 1434, Strasbourg, France Hospital Universitario Virgen Macarena (G.I., S.E.), Sevilla, Spain CHU Pontchaillou (G.E.), CIC1414 INSERM, Rennes, France CHUM MS Center and Universite de Montreal (A.P., M.G.), Canada Dokuz Eylul University (S.O.), Konak/Izmir, Turkey CISSS Chaudière-Appalache (P.G.), Levis, Canada CHU Lille (H.Z.), CRCSEP Lille, Univ Lille, U1172, France CHU de Toulouse (J.C.), Hôpital Pierre-Paul Riquet, Department of Neurology, CRC-SEP, France Département de Neurologie (E.M.), Hôpital Pitié-Salpêtrière, APHP, Paris CHU de Dijon (T.M.), Department of Neurology, EA4184, France Department NEUROFARBA (M.P.A.), University of Florence, Italy CHU de Montpellier (P.L.), MS Unit, France University of Montpellier (MUSE) (P.L.), France Division of Neurology (Raed Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait Department of Neurology (K.B., O.S.), Box Hill Hospital, Melbourne, Australia Monash University (K.B., O.S.), Melbourne, Australia Melbourne MS Centre (K.B.), Royal Melbourne Hospital, Australia The Alfred Hospital (O.S.), Melbourne, Australia Medical Faculty (M.T.), 19 Mayis University, Samsun, Turkey CHU de Nantes (D.A.L.), Service de Neurologie & CIC015 INSERM, France CRTI-Inserm U1064 (D.A.L.), Nantes, France CHU de Besançon (E.B.), Service de Neurologie 25 030 Besançon, France Neuro Rive-Sud (F.G.M.), Quebec, Canada Neurology (C.L.-F.), UR2CA, Centre Hospitalier Universitaire Pasteur2, Université Nice Côte d'Azur, Nice, France UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy KTU Medical Faculty Farabi Hospital (C.B.), Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle, Australia Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia CHU Clermont-Ferrand (Pierre Clavelou), Department of Neurology Université Clermont Auvergne, Inserm, Neuro-Dol, Clermont-Ferrand, France Sorbonne Universités (B.S.), UPMC Paris 06, Brain and Spine Institute, ICM, Hôpital de La Pitié Salpêtrière, Inserm UMR S 1127, CNRS UMR 7225, and Department of Neurology, AP-HP, Saint-Antoine Hospital, Paris, France CSSS Saint-Jérôme (Julie Prevost), Saint-Jerome, Canada Neurologic Clinic and Policlinic (L.K.), Departments of Medicine and Clinical Research, University Hospital and University of Basel, Switzerland Aix Marseille Univ (Jean Pelletier), APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, France Isfahan University of Medical Sciences (V.S.), Iran Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y., S.J.K.), American University of Beirut Medical Center, Beirut, Lebanon Department of Neurology (Oliver Gerlach), Zuyderland Medical Center, Sittard-Geleen, Netherlands Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy Cliniques Universitaires Saint-Luc (V.V.P.), Université Catholique de Louvain, Brussels, Belgium Fondation Rotschild (Olivier Gout), Department of Neurology, Paris, France Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Hôpital de Poissy (O.H.), Department of Neurology, France Department of Neurology (E.T.), Nimes University Hospital, France Institut de Génomique Fonctionnelle (E.T.), UMR5203, INSERM 1191, Univ. Montpellier, France University of Queensland (P.A.M.), Brisbane, Australia Royal Brisbane and Women's Hospital (P.A.M.), Australia Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey CHU de Rouen (B.B.), Department of Neurology, France Flinders University (M.S.), Adelaide, Australia Instituto de Investigación Sanitaria Biodonostia (T.C.-T.), Hospital Universitario Donostia, San Sebastián, Spain CHU de Reims (S.B.), Department of Neurology, France Nemocnice Jihlava (Radek Ampapa), Czech Republic Monash Medical Centre (E.G.B.), Melbourne, Australia APHP (A.W.), Hôpital Henri Mondor, Department of Neurology, Créteil, France Austin Health (R.A.M.), Melbourne, Australia University Hospital Reina Sofia (E.A.-M.), Cordoba, Spain CHU de La Martinique (Philippe Cabre), Department of Neurology, Fort-de-France, France Hôpital Sud Francilien (N.H.B.), Department of Neurology, Corbeil Essonnes, France Department of Neurology (A.V.W., H.B.), The Alfred Hospital, Melbourne, Australia Central Clinical School (A.V.W., H.B.), Monash University, Melbourne, Australia Department of Neurology (G.L., L.V.H.), University Hospital Ghent, Belgium Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain CHU La Milétrie (N.M.), Hôpital Jean Bernard, Department of Neurology, Poitiers, France Liverpool Hospital (S.H.), Sydney, Australia Hospital de Galdakao-Usansolo (J.L.S.-M.), Spain Brain and Mind Centre (M.H.B.), Sydney, Australia CHU Bicêtre (C.L.), Department of Neurology, F-94275 Le Kremlin Bicêtre, France Westmead Hospital (Steve Vucic), Sydney, Australia Department of Neurology (Y.S., R.G.), Razi Hospital, Manouba, Tunisia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Hospital Universitari MútuaTerrassa (J.S.), Barcelona, Spain Groene Hart Ziekenhuis (K.G.), Gouda, Netherlands Sultan Qaboos University Hospital (A.A.-A.), Al-Khodh, Oman Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil Service de Neurologie (Sandra Vukusic), Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France Centre des Neurosciences de Lyon (Sandra Vukusic), Observatoire Français de La Sclérose en Plaques, INSERM 1028 et CNRS UMR5292, France and Université Claude Bernard Lyon 1 (Sandra Vukusic), Faculté de Médecine Lyon Est, France
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Casey, Romain
Autor Casey, Romain ORCID From the CORe (I.R., C.M., T.K.), Department of Medicine, University of Melbourne, Australia Melbourne MS Centre (I.R., C.M., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia Rennes, University (E.L.), EHESP, REPERES EA 7449, France Univ Rennes (E.L.), CHU Rennes, Inserm, CIC 1414 ([Centre d'Investigation Clinique de Rennes]), France Université de Lyon (R.C.), Université Claude Bernard Lyon 1, France Hospices Civils de Lyon (R.C.), Service de Neurologie, Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Bron, France Observatoire Français de La Sclérose en Plaques (R.C.), Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, France Eugène Devic EDMUS Foundation Against Multiple Sclerosis (R.C.), State-approved Foundation, Bron, France Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic Nancy University Hospital (M.D.), Department of Neurology, Nancy, France Université de Lorraine (M.D.), APEMAC, Nancy, France Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania, Italy Multiple Sclerosis Center (F.P.), University of Catania, Italy CHU de Strasbourg (J.D.S.), Department of Neurology and Clinical Investigation Center, CIC 1434, INSERM 1434, Strasbourg, France Hospital Universitario Virgen Macarena (G.I., S.E.), Sevilla, Spain CHU Pontchaillou (G.E.), CIC1414 INSERM, Rennes, France CHUM MS Center and Universite de Montreal (A.P., M.G.), Canada Dokuz Eylul University (S.O.), Konak/Izmir, Turkey CISSS Chaudière-Appalache (P.G.), Levis, Canada CHU Lille (H.Z.), CRCSEP Lille, Univ Lille, U1172, France CHU de Toulouse (J.C.), Hôpital Pierre-Paul Riquet, Department of Neurology, CRC-SEP, France Département de Neurologie (E.M.), Hôpital Pitié-Salpêtrière, APHP, Paris CHU de Dijon (T.M.), Department of Neurology, EA4184, France Department NEUROFARBA (M.P.A.), University of Florence, Italy CHU de Montpellier (P.L.), MS Unit, France University of Montpellier (MUSE) (P.L.), France Division of Neurology (Raed Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait Department of Neurology (K.B., O.S.), Box Hill Hospital, Melbourne, Australia Monash University (K.B., O.S.), Melbourne, Australia Melbourne MS Centre (K.B.), Royal Melbourne Hospital, Australia The Alfred Hospital (O.S.), Melbourne, Australia Medical Faculty (M.T.), 19 Mayis University, Samsun, Turkey CHU de Nantes (D.A.L.), Service de Neurologie & CIC015 INSERM, France CRTI-Inserm U1064 (D.A.L.), Nantes, France CHU de Besançon (E.B.), Service de Neurologie 25 030 Besançon, France Neuro Rive-Sud (F.G.M.), Quebec, Canada Neurology (C.L.-F.), UR2CA, Centre Hospitalier Universitaire Pasteur2, Université Nice Côte d'Azur, Nice, France UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy KTU Medical Faculty Farabi Hospital (C.B.), Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle, Australia Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia CHU Clermont-Ferrand (Pierre Clavelou), Department of Neurology Université Clermont Auvergne, Inserm, Neuro-Dol, Clermont-Ferrand, France Sorbonne Universités (B.S.), UPMC Paris 06, Brain and Spine Institute, ICM, Hôpital de La Pitié Salpêtrière, Inserm UMR S 1127, CNRS UMR 7225, and Department of Neurology, AP-HP, Saint-Antoine Hospital, Paris, France CSSS Saint-Jérôme (Julie Prevost), Saint-Jerome, Canada Neurologic Clinic and Policlinic (L.K.), Departments of Medicine and Clinical Research, University Hospital and University of Basel, Switzerland Aix Marseille Univ (Jean Pelletier), APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, France Isfahan University of Medical Sciences (V.S.), Iran Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y., S.J.K.), American University of Beirut Medical Center, Beirut, Lebanon Department of Neurology (Oliver Gerlach), Zuyderland Medical Center, Sittard-Geleen, Netherlands Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy Cliniques Universitaires Saint-Luc (V.V.P.), Université Catholique de Louvain, Brussels, Belgium Fondation Rotschild (Olivier Gout), Department of Neurology, Paris, France Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Hôpital de Poissy (O.H.), Department of Neurology, France Department of Neurology (E.T.), Nimes University Hospital, France Institut de Génomique Fonctionnelle (E.T.), UMR5203, INSERM 1191, Univ. Montpellier, France University of Queensland (P.A.M.), Brisbane, Australia Royal Brisbane and Women's Hospital (P.A.M.), Australia Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey CHU de Rouen (B.B.), Department of Neurology, France Flinders University (M.S.), Adelaide, Australia Instituto de Investigación Sanitaria Biodonostia (T.C.-T.), Hospital Universitario Donostia, San Sebastián, Spain CHU de Reims (S.B.), Department of Neurology, France Nemocnice Jihlava (Radek Ampapa), Czech Republic Monash Medical Centre (E.G.B.), Melbourne, Australia APHP (A.W.), Hôpital Henri Mondor, Department of Neurology, Créteil, France Austin Health (R.A.M.), Melbourne, Australia University Hospital Reina Sofia (E.A.-M.), Cordoba, Spain CHU de La Martinique (Philippe Cabre), Department of Neurology, Fort-de-France, France Hôpital Sud Francilien (N.H.B.), Department of Neurology, Corbeil Essonnes, France Department of Neurology (A.V.W., H.B.), The Alfred Hospital, Melbourne, Australia Central Clinical School (A.V.W., H.B.), Monash University, Melbourne, Australia Department of Neurology (G.L., L.V.H.), University Hospital Ghent, Belgium Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain CHU La Milétrie (N.M.), Hôpital Jean Bernard, Department of Neurology, Poitiers, France Liverpool Hospital (S.H.), Sydney, Australia Hospital de Galdakao-Usansolo (J.L.S.-M.), Spain Brain and Mind Centre (M.H.B.), Sydney, Australia CHU Bicêtre (C.L.), Department of Neurology, F-94275 Le Kremlin Bicêtre, France Westmead Hospital (Steve Vucic), Sydney, Australia Department of Neurology (Y.S., R.G.), Razi Hospital, Manouba, Tunisia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Hospital Universitari MútuaTerrassa (J.S.), Barcelona, Spain Groene Hart Ziekenhuis (K.G.), Gouda, Netherlands Sultan Qaboos University Hospital (A.A.-A.), Al-Khodh, Oman Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil Service de Neurologie (Sandra Vukusic), Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France Centre des Neurosciences de Lyon (Sandra Vukusic), Observatoire Français de La Sclérose en Plaques, INSERM 1028 et CNRS UMR5292, France and Université Claude Bernard Lyon 1 (Sandra Vukusic), Faculté de Médecine Lyon Est, France
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Horakova, Dana
Autor Horakova, Dana From the CORe (I.R., C.M., T.K.), Department of Medicine, University of Melbourne, Australia Melbourne MS Centre (I.R., C.M., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia Rennes, University (E.L.), EHESP, REPERES EA 7449, France Univ Rennes (E.L.), CHU Rennes, Inserm, CIC 1414 ([Centre d'Investigation Clinique de Rennes]), France Université de Lyon (R.C.), Université Claude Bernard Lyon 1, France Hospices Civils de Lyon (R.C.), Service de Neurologie, Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Bron, France Observatoire Français de La Sclérose en Plaques (R.C.), Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, France Eugène Devic EDMUS Foundation Against Multiple Sclerosis (R.C.), State-approved Foundation, Bron, France Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic Nancy University Hospital (M.D.), Department of Neurology, Nancy, France Université de Lorraine (M.D.), APEMAC, Nancy, France Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania, Italy Multiple Sclerosis Center (F.P.), University of Catania, Italy CHU de Strasbourg (J.D.S.), Department of Neurology and Clinical Investigation Center, CIC 1434, INSERM 1434, Strasbourg, France Hospital Universitario Virgen Macarena (G.I., S.E.), Sevilla, Spain CHU Pontchaillou (G.E.), CIC1414 INSERM, Rennes, France CHUM MS Center and Universite de Montreal (A.P., M.G.), Canada Dokuz Eylul University (S.O.), Konak/Izmir, Turkey CISSS Chaudière-Appalache (P.G.), Levis, Canada CHU Lille (H.Z.), CRCSEP Lille, Univ Lille, U1172, France CHU de Toulouse (J.C.), Hôpital Pierre-Paul Riquet, Department of Neurology, CRC-SEP, France Département de Neurologie (E.M.), Hôpital Pitié-Salpêtrière, APHP, Paris CHU de Dijon (T.M.), Department of Neurology, EA4184, France Department NEUROFARBA (M.P.A.), University of Florence, Italy CHU de Montpellier (P.L.), MS Unit, France University of Montpellier (MUSE) (P.L.), France Division of Neurology (Raed Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait Department of Neurology (K.B., O.S.), Box Hill Hospital, Melbourne, Australia Monash University (K.B., O.S.), Melbourne, Australia Melbourne MS Centre (K.B.), Royal Melbourne Hospital, Australia The Alfred Hospital (O.S.), Melbourne, Australia Medical Faculty (M.T.), 19 Mayis University, Samsun, Turkey CHU de Nantes (D.A.L.), Service de Neurologie & CIC015 INSERM, France CRTI-Inserm U1064 (D.A.L.), Nantes, France CHU de Besançon (E.B.), Service de Neurologie 25 030 Besançon, France Neuro Rive-Sud (F.G.M.), Quebec, Canada Neurology (C.L.-F.), UR2CA, Centre Hospitalier Universitaire Pasteur2, Université Nice Côte d'Azur, Nice, France UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy KTU Medical Faculty Farabi Hospital (C.B.), Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle, Australia Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia CHU Clermont-Ferrand (Pierre Clavelou), Department of Neurology Université Clermont Auvergne, Inserm, Neuro-Dol, Clermont-Ferrand, France Sorbonne Universités (B.S.), UPMC Paris 06, Brain and Spine Institute, ICM, Hôpital de La Pitié Salpêtrière, Inserm UMR S 1127, CNRS UMR 7225, and Department of Neurology, AP-HP, Saint-Antoine Hospital, Paris, France CSSS Saint-Jérôme (Julie Prevost), Saint-Jerome, Canada Neurologic Clinic and Policlinic (L.K.), Departments of Medicine and Clinical Research, University Hospital and University of Basel, Switzerland Aix Marseille Univ (Jean Pelletier), APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, France Isfahan University of Medical Sciences (V.S.), Iran Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y., S.J.K.), American University of Beirut Medical Center, Beirut, Lebanon Department of Neurology (Oliver Gerlach), Zuyderland Medical Center, Sittard-Geleen, Netherlands Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy Cliniques Universitaires Saint-Luc (V.V.P.), Université Catholique de Louvain, Brussels, Belgium Fondation Rotschild (Olivier Gout), Department of Neurology, Paris, France Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Hôpital de Poissy (O.H.), Department of Neurology, France Department of Neurology (E.T.), Nimes University Hospital, France Institut de Génomique Fonctionnelle (E.T.), UMR5203, INSERM 1191, Univ. Montpellier, France University of Queensland (P.A.M.), Brisbane, Australia Royal Brisbane and Women's Hospital (P.A.M.), Australia Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey CHU de Rouen (B.B.), Department of Neurology, France Flinders University (M.S.), Adelaide, Australia Instituto de Investigación Sanitaria Biodonostia (T.C.-T.), Hospital Universitario Donostia, San Sebastián, Spain CHU de Reims (S.B.), Department of Neurology, France Nemocnice Jihlava (Radek Ampapa), Czech Republic Monash Medical Centre (E.G.B.), Melbourne, Australia APHP (A.W.), Hôpital Henri Mondor, Department of Neurology, Créteil, France Austin Health (R.A.M.), Melbourne, Australia University Hospital Reina Sofia (E.A.-M.), Cordoba, Spain CHU de La Martinique (Philippe Cabre), Department of Neurology, Fort-de-France, France Hôpital Sud Francilien (N.H.B.), Department of Neurology, Corbeil Essonnes, France Department of Neurology (A.V.W., H.B.), The Alfred Hospital, Melbourne, Australia Central Clinical School (A.V.W., H.B.), Monash University, Melbourne, Australia Department of Neurology (G.L., L.V.H.), University Hospital Ghent, Belgium Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain CHU La Milétrie (N.M.), Hôpital Jean Bernard, Department of Neurology, Poitiers, France Liverpool Hospital (S.H.), Sydney, Australia Hospital de Galdakao-Usansolo (J.L.S.-M.), Spain Brain and Mind Centre (M.H.B.), Sydney, Australia CHU Bicêtre (C.L.), Department of Neurology, F-94275 Le Kremlin Bicêtre, France Westmead Hospital (Steve Vucic), Sydney, Australia Department of Neurology (Y.S., R.G.), Razi Hospital, Manouba, Tunisia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Hospital Universitari MútuaTerrassa (J.S.), Barcelona, Spain Groene Hart Ziekenhuis (K.G.), Gouda, Netherlands Sultan Qaboos University Hospital (A.A.-A.), Al-Khodh, Oman Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil Service de Neurologie (Sandra Vukusic), Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France Centre des Neurosciences de Lyon (Sandra Vukusic), Observatoire Français de La Sclérose en Plaques, INSERM 1028 et CNRS UMR5292, France and Université Claude Bernard Lyon 1 (Sandra Vukusic), Faculté de Médecine Lyon Est, France
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Havrdova, Eva Kubala
Autor Havrdova, Eva Kubala From the CORe (I.R., C.M., T.K.), Department of Medicine, University of Melbourne, Australia Melbourne MS Centre (I.R., C.M., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia Rennes, University (E.L.), EHESP, REPERES EA 7449, France Univ Rennes (E.L.), CHU Rennes, Inserm, CIC 1414 ([Centre d'Investigation Clinique de Rennes]), France Université de Lyon (R.C.), Université Claude Bernard Lyon 1, France Hospices Civils de Lyon (R.C.), Service de Neurologie, Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Bron, France Observatoire Français de La Sclérose en Plaques (R.C.), Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, France Eugène Devic EDMUS Foundation Against Multiple Sclerosis (R.C.), State-approved Foundation, Bron, France Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic Nancy University Hospital (M.D.), Department of Neurology, Nancy, France Université de Lorraine (M.D.), APEMAC, Nancy, France Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania, Italy Multiple Sclerosis Center (F.P.), University of Catania, Italy CHU de Strasbourg (J.D.S.), Department of Neurology and Clinical Investigation Center, CIC 1434, INSERM 1434, Strasbourg, France Hospital Universitario Virgen Macarena (G.I., S.E.), Sevilla, Spain CHU Pontchaillou (G.E.), CIC1414 INSERM, Rennes, France CHUM MS Center and Universite de Montreal (A.P., M.G.), Canada Dokuz Eylul University (S.O.), Konak/Izmir, Turkey CISSS Chaudière-Appalache (P.G.), Levis, Canada CHU Lille (H.Z.), CRCSEP Lille, Univ Lille, U1172, France CHU de Toulouse (J.C.), Hôpital Pierre-Paul Riquet, Department of Neurology, CRC-SEP, France Département de Neurologie (E.M.), Hôpital Pitié-Salpêtrière, APHP, Paris CHU de Dijon (T.M.), Department of Neurology, EA4184, France Department NEUROFARBA (M.P.A.), University of Florence, Italy CHU de Montpellier (P.L.), MS Unit, France University of Montpellier (MUSE) (P.L.), France Division of Neurology (Raed Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait Department of Neurology (K.B., O.S.), Box Hill Hospital, Melbourne, Australia Monash University (K.B., O.S.), Melbourne, Australia Melbourne MS Centre (K.B.), Royal Melbourne Hospital, Australia The Alfred Hospital (O.S.), Melbourne, Australia Medical Faculty (M.T.), 19 Mayis University, Samsun, Turkey CHU de Nantes (D.A.L.), Service de Neurologie & CIC015 INSERM, France CRTI-Inserm U1064 (D.A.L.), Nantes, France CHU de Besançon (E.B.), Service de Neurologie 25 030 Besançon, France Neuro Rive-Sud (F.G.M.), Quebec, Canada Neurology (C.L.-F.), UR2CA, Centre Hospitalier Universitaire Pasteur2, Université Nice Côte d'Azur, Nice, France UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy KTU Medical Faculty Farabi Hospital (C.B.), Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle, Australia Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia CHU Clermont-Ferrand (Pierre Clavelou), Department of Neurology Université Clermont Auvergne, Inserm, Neuro-Dol, Clermont-Ferrand, France Sorbonne Universités (B.S.), UPMC Paris 06, Brain and Spine Institute, ICM, Hôpital de La Pitié Salpêtrière, Inserm UMR S 1127, CNRS UMR 7225, and Department of Neurology, AP-HP, Saint-Antoine Hospital, Paris, France CSSS Saint-Jérôme (Julie Prevost), Saint-Jerome, Canada Neurologic Clinic and Policlinic (L.K.), Departments of Medicine and Clinical Research, University Hospital and University of Basel, Switzerland Aix Marseille Univ (Jean Pelletier), APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, France Isfahan University of Medical Sciences (V.S.), Iran Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y., S.J.K.), American University of Beirut Medical Center, Beirut, Lebanon Department of Neurology (Oliver Gerlach), Zuyderland Medical Center, Sittard-Geleen, Netherlands Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy Cliniques Universitaires Saint-Luc (V.V.P.), Université Catholique de Louvain, Brussels, Belgium Fondation Rotschild (Olivier Gout), Department of Neurology, Paris, France Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Hôpital de Poissy (O.H.), Department of Neurology, France Department of Neurology (E.T.), Nimes University Hospital, France Institut de Génomique Fonctionnelle (E.T.), UMR5203, INSERM 1191, Univ. Montpellier, France University of Queensland (P.A.M.), Brisbane, Australia Royal Brisbane and Women's Hospital (P.A.M.), Australia Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey CHU de Rouen (B.B.), Department of Neurology, France Flinders University (M.S.), Adelaide, Australia Instituto de Investigación Sanitaria Biodonostia (T.C.-T.), Hospital Universitario Donostia, San Sebastián, Spain CHU de Reims (S.B.), Department of Neurology, France Nemocnice Jihlava (Radek Ampapa), Czech Republic Monash Medical Centre (E.G.B.), Melbourne, Australia APHP (A.W.), Hôpital Henri Mondor, Department of Neurology, Créteil, France Austin Health (R.A.M.), Melbourne, Australia University Hospital Reina Sofia (E.A.-M.), Cordoba, Spain CHU de La Martinique (Philippe Cabre), Department of Neurology, Fort-de-France, France Hôpital Sud Francilien (N.H.B.), Department of Neurology, Corbeil Essonnes, France Department of Neurology (A.V.W., H.B.), The Alfred Hospital, Melbourne, Australia Central Clinical School (A.V.W., H.B.), Monash University, Melbourne, Australia Department of Neurology (G.L., L.V.H.), University Hospital Ghent, Belgium Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain CHU La Milétrie (N.M.), Hôpital Jean Bernard, Department of Neurology, Poitiers, France Liverpool Hospital (S.H.), Sydney, Australia Hospital de Galdakao-Usansolo (J.L.S.-M.), Spain Brain and Mind Centre (M.H.B.), Sydney, Australia CHU Bicêtre (C.L.), Department of Neurology, F-94275 Le Kremlin Bicêtre, France Westmead Hospital (Steve Vucic), Sydney, Australia Department of Neurology (Y.S., R.G.), Razi Hospital, Manouba, Tunisia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Hospital Universitari MútuaTerrassa (J.S.), Barcelona, Spain Groene Hart Ziekenhuis (K.G.), Gouda, Netherlands Sultan Qaboos University Hospital (A.A.-A.), Al-Khodh, Oman Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil Service de Neurologie (Sandra Vukusic), Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France Centre des Neurosciences de Lyon (Sandra Vukusic), Observatoire Français de La Sclérose en Plaques, INSERM 1028 et CNRS UMR5292, France and Université Claude Bernard Lyon 1 (Sandra Vukusic), Faculté de Médecine Lyon Est, France
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Debouverie, Marc
Autor Debouverie, Marc From the CORe (I.R., C.M., T.K.), Department of Medicine, University of Melbourne, Australia Melbourne MS Centre (I.R., C.M., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia Rennes, University (E.L.), EHESP, REPERES EA 7449, France Univ Rennes (E.L.), CHU Rennes, Inserm, CIC 1414 ([Centre d'Investigation Clinique de Rennes]), France Université de Lyon (R.C.), Université Claude Bernard Lyon 1, France Hospices Civils de Lyon (R.C.), Service de Neurologie, Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Bron, France Observatoire Français de La Sclérose en Plaques (R.C.), Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, France Eugène Devic EDMUS Foundation Against Multiple Sclerosis (R.C.), State-approved Foundation, Bron, France Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic Nancy University Hospital (M.D.), Department of Neurology, Nancy, France Université de Lorraine (M.D.), APEMAC, Nancy, France Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania, Italy Multiple Sclerosis Center (F.P.), University of Catania, Italy CHU de Strasbourg (J.D.S.), Department of Neurology and Clinical Investigation Center, CIC 1434, INSERM 1434, Strasbourg, France Hospital Universitario Virgen Macarena (G.I., S.E.), Sevilla, Spain CHU Pontchaillou (G.E.), CIC1414 INSERM, Rennes, France CHUM MS Center and Universite de Montreal (A.P., M.G.), Canada Dokuz Eylul University (S.O.), Konak/Izmir, Turkey CISSS Chaudière-Appalache (P.G.), Levis, Canada CHU Lille (H.Z.), CRCSEP Lille, Univ Lille, U1172, France CHU de Toulouse (J.C.), Hôpital Pierre-Paul Riquet, Department of Neurology, CRC-SEP, France Département de Neurologie (E.M.), Hôpital Pitié-Salpêtrière, APHP, Paris CHU de Dijon (T.M.), Department of Neurology, EA4184, France Department NEUROFARBA (M.P.A.), University of Florence, Italy CHU de Montpellier (P.L.), MS Unit, France University of Montpellier (MUSE) (P.L.), France Division of Neurology (Raed Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait Department of Neurology (K.B., O.S.), Box Hill Hospital, Melbourne, Australia Monash University (K.B., O.S.), Melbourne, Australia Melbourne MS Centre (K.B.), Royal Melbourne Hospital, Australia The Alfred Hospital (O.S.), Melbourne, Australia Medical Faculty (M.T.), 19 Mayis University, Samsun, Turkey CHU de Nantes (D.A.L.), Service de Neurologie & CIC015 INSERM, France CRTI-Inserm U1064 (D.A.L.), Nantes, France CHU de Besançon (E.B.), Service de Neurologie 25 030 Besançon, France Neuro Rive-Sud (F.G.M.), Quebec, Canada Neurology (C.L.-F.), UR2CA, Centre Hospitalier Universitaire Pasteur2, Université Nice Côte d'Azur, Nice, France UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy KTU Medical Faculty Farabi Hospital (C.B.), Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle, Australia Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia CHU Clermont-Ferrand (Pierre Clavelou), Department of Neurology Université Clermont Auvergne, Inserm, Neuro-Dol, Clermont-Ferrand, France Sorbonne Universités (B.S.), UPMC Paris 06, Brain and Spine Institute, ICM, Hôpital de La Pitié Salpêtrière, Inserm UMR S 1127, CNRS UMR 7225, and Department of Neurology, AP-HP, Saint-Antoine Hospital, Paris, France CSSS Saint-Jérôme (Julie Prevost), Saint-Jerome, Canada Neurologic Clinic and Policlinic (L.K.), Departments of Medicine and Clinical Research, University Hospital and University of Basel, Switzerland Aix Marseille Univ (Jean Pelletier), APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, France Isfahan University of Medical Sciences (V.S.), Iran Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y., S.J.K.), American University of Beirut Medical Center, Beirut, Lebanon Department of Neurology (Oliver Gerlach), Zuyderland Medical Center, Sittard-Geleen, Netherlands Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy Cliniques Universitaires Saint-Luc (V.V.P.), Université Catholique de Louvain, Brussels, Belgium Fondation Rotschild (Olivier Gout), Department of Neurology, Paris, France Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Hôpital de Poissy (O.H.), Department of Neurology, France Department of Neurology (E.T.), Nimes University Hospital, France Institut de Génomique Fonctionnelle (E.T.), UMR5203, INSERM 1191, Univ. Montpellier, France University of Queensland (P.A.M.), Brisbane, Australia Royal Brisbane and Women's Hospital (P.A.M.), Australia Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey CHU de Rouen (B.B.), Department of Neurology, France Flinders University (M.S.), Adelaide, Australia Instituto de Investigación Sanitaria Biodonostia (T.C.-T.), Hospital Universitario Donostia, San Sebastián, Spain CHU de Reims (S.B.), Department of Neurology, France Nemocnice Jihlava (Radek Ampapa), Czech Republic Monash Medical Centre (E.G.B.), Melbourne, Australia APHP (A.W.), Hôpital Henri Mondor, Department of Neurology, Créteil, France Austin Health (R.A.M.), Melbourne, Australia University Hospital Reina Sofia (E.A.-M.), Cordoba, Spain CHU de La Martinique (Philippe Cabre), Department of Neurology, Fort-de-France, France Hôpital Sud Francilien (N.H.B.), Department of Neurology, Corbeil Essonnes, France Department of Neurology (A.V.W., H.B.), The Alfred Hospital, Melbourne, Australia Central Clinical School (A.V.W., H.B.), Monash University, Melbourne, Australia Department of Neurology (G.L., L.V.H.), University Hospital Ghent, Belgium Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain CHU La Milétrie (N.M.), Hôpital Jean Bernard, Department of Neurology, Poitiers, France Liverpool Hospital (S.H.), Sydney, Australia Hospital de Galdakao-Usansolo (J.L.S.-M.), Spain Brain and Mind Centre (M.H.B.), Sydney, Australia CHU Bicêtre (C.L.), Department of Neurology, F-94275 Le Kremlin Bicêtre, France Westmead Hospital (Steve Vucic), Sydney, Australia Department of Neurology (Y.S., R.G.), Razi Hospital, Manouba, Tunisia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Hospital Universitari MútuaTerrassa (J.S.), Barcelona, Spain Groene Hart Ziekenhuis (K.G.), Gouda, Netherlands Sultan Qaboos University Hospital (A.A.-A.), Al-Khodh, Oman Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil Service de Neurologie (Sandra Vukusic), Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France Centre des Neurosciences de Lyon (Sandra Vukusic), Observatoire Français de La Sclérose en Plaques, INSERM 1028 et CNRS UMR5292, France and Université Claude Bernard Lyon 1 (Sandra Vukusic), Faculté de Médecine Lyon Est, France
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Patti, Francesco
Autor Patti, Francesco From the CORe (I.R., C.M., T.K.), Department of Medicine, University of Melbourne, Australia Melbourne MS Centre (I.R., C.M., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia Rennes, University (E.L.), EHESP, REPERES EA 7449, France Univ Rennes (E.L.), CHU Rennes, Inserm, CIC 1414 ([Centre d'Investigation Clinique de Rennes]), France Université de Lyon (R.C.), Université Claude Bernard Lyon 1, France Hospices Civils de Lyon (R.C.), Service de Neurologie, Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Bron, France Observatoire Français de La Sclérose en Plaques (R.C.), Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, France Eugène Devic EDMUS Foundation Against Multiple Sclerosis (R.C.), State-approved Foundation, Bron, France Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic Nancy University Hospital (M.D.), Department of Neurology, Nancy, France Université de Lorraine (M.D.), APEMAC, Nancy, France Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania, Italy Multiple Sclerosis Center (F.P.), University of Catania, Italy CHU de Strasbourg (J.D.S.), Department of Neurology and Clinical Investigation Center, CIC 1434, INSERM 1434, Strasbourg, France Hospital Universitario Virgen Macarena (G.I., S.E.), Sevilla, Spain CHU Pontchaillou (G.E.), CIC1414 INSERM, Rennes, France CHUM MS Center and Universite de Montreal (A.P., M.G.), Canada Dokuz Eylul University (S.O.), Konak/Izmir, Turkey CISSS Chaudière-Appalache (P.G.), Levis, Canada CHU Lille (H.Z.), CRCSEP Lille, Univ Lille, U1172, France CHU de Toulouse (J.C.), Hôpital Pierre-Paul Riquet, Department of Neurology, CRC-SEP, France Département de Neurologie (E.M.), Hôpital Pitié-Salpêtrière, APHP, Paris CHU de Dijon (T.M.), Department of Neurology, EA4184, France Department NEUROFARBA (M.P.A.), University of Florence, Italy CHU de Montpellier (P.L.), MS Unit, France University of Montpellier (MUSE) (P.L.), France Division of Neurology (Raed Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait Department of Neurology (K.B., O.S.), Box Hill Hospital, Melbourne, Australia Monash University (K.B., O.S.), Melbourne, Australia Melbourne MS Centre (K.B.), Royal Melbourne Hospital, Australia The Alfred Hospital (O.S.), Melbourne, Australia Medical Faculty (M.T.), 19 Mayis University, Samsun, Turkey CHU de Nantes (D.A.L.), Service de Neurologie & CIC015 INSERM, France CRTI-Inserm U1064 (D.A.L.), Nantes, France CHU de Besançon (E.B.), Service de Neurologie 25 030 Besançon, France Neuro Rive-Sud (F.G.M.), Quebec, Canada Neurology (C.L.-F.), UR2CA, Centre Hospitalier Universitaire Pasteur2, Université Nice Côte d'Azur, Nice, France UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy KTU Medical Faculty Farabi Hospital (C.B.), Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle, Australia Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia CHU Clermont-Ferrand (Pierre Clavelou), Department of Neurology Université Clermont Auvergne, Inserm, Neuro-Dol, Clermont-Ferrand, France Sorbonne Universités (B.S.), UPMC Paris 06, Brain and Spine Institute, ICM, Hôpital de La Pitié Salpêtrière, Inserm UMR S 1127, CNRS UMR 7225, and Department of Neurology, AP-HP, Saint-Antoine Hospital, Paris, France CSSS Saint-Jérôme (Julie Prevost), Saint-Jerome, Canada Neurologic Clinic and Policlinic (L.K.), Departments of Medicine and Clinical Research, University Hospital and University of Basel, Switzerland Aix Marseille Univ (Jean Pelletier), APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, France Isfahan University of Medical Sciences (V.S.), Iran Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y., S.J.K.), American University of Beirut Medical Center, Beirut, Lebanon Department of Neurology (Oliver Gerlach), Zuyderland Medical Center, Sittard-Geleen, Netherlands Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy Cliniques Universitaires Saint-Luc (V.V.P.), Université Catholique de Louvain, Brussels, Belgium Fondation Rotschild (Olivier Gout), Department of Neurology, Paris, France Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Hôpital de Poissy (O.H.), Department of Neurology, France Department of Neurology (E.T.), Nimes University Hospital, France Institut de Génomique Fonctionnelle (E.T.), UMR5203, INSERM 1191, Univ. Montpellier, France University of Queensland (P.A.M.), Brisbane, Australia Royal Brisbane and Women's Hospital (P.A.M.), Australia Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey CHU de Rouen (B.B.), Department of Neurology, France Flinders University (M.S.), Adelaide, Australia Instituto de Investigación Sanitaria Biodonostia (T.C.-T.), Hospital Universitario Donostia, San Sebastián, Spain CHU de Reims (S.B.), Department of Neurology, France Nemocnice Jihlava (Radek Ampapa), Czech Republic Monash Medical Centre (E.G.B.), Melbourne, Australia APHP (A.W.), Hôpital Henri Mondor, Department of Neurology, Créteil, France Austin Health (R.A.M.), Melbourne, Australia University Hospital Reina Sofia (E.A.-M.), Cordoba, Spain CHU de La Martinique (Philippe Cabre), Department of Neurology, Fort-de-France, France Hôpital Sud Francilien (N.H.B.), Department of Neurology, Corbeil Essonnes, France Department of Neurology (A.V.W., H.B.), The Alfred Hospital, Melbourne, Australia Central Clinical School (A.V.W., H.B.), Monash University, Melbourne, Australia Department of Neurology (G.L., L.V.H.), University Hospital Ghent, Belgium Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain CHU La Milétrie (N.M.), Hôpital Jean Bernard, Department of Neurology, Poitiers, France Liverpool Hospital (S.H.), Sydney, Australia Hospital de Galdakao-Usansolo (J.L.S.-M.), Spain Brain and Mind Centre (M.H.B.), Sydney, Australia CHU Bicêtre (C.L.), Department of Neurology, F-94275 Le Kremlin Bicêtre, France Westmead Hospital (Steve Vucic), Sydney, Australia Department of Neurology (Y.S., R.G.), Razi Hospital, Manouba, Tunisia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Hospital Universitari MútuaTerrassa (J.S.), Barcelona, Spain Groene Hart Ziekenhuis (K.G.), Gouda, Netherlands Sultan Qaboos University Hospital (A.A.-A.), Al-Khodh, Oman Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil Service de Neurologie (Sandra Vukusic), Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France Centre des Neurosciences de Lyon (Sandra Vukusic), Observatoire Français de La Sclérose en Plaques, INSERM 1028 et CNRS UMR5292, France and Université Claude Bernard Lyon 1 (Sandra Vukusic), Faculté de Médecine Lyon Est, France
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De Seze, Jerome
Autor De Seze, Jerome From the CORe (I.R., C.M., T.K.), Department of Medicine, University of Melbourne, Australia Melbourne MS Centre (I.R., C.M., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia Rennes, University (E.L.), EHESP, REPERES EA 7449, France Univ Rennes (E.L.), CHU Rennes, Inserm, CIC 1414 ([Centre d'Investigation Clinique de Rennes]), France Université de Lyon (R.C.), Université Claude Bernard Lyon 1, France Hospices Civils de Lyon (R.C.), Service de Neurologie, Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Bron, France Observatoire Français de La Sclérose en Plaques (R.C.), Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, France Eugène Devic EDMUS Foundation Against Multiple Sclerosis (R.C.), State-approved Foundation, Bron, France Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic Nancy University Hospital (M.D.), Department of Neurology, Nancy, France Université de Lorraine (M.D.), APEMAC, Nancy, France Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania, Italy Multiple Sclerosis Center (F.P.), University of Catania, Italy CHU de Strasbourg (J.D.S.), Department of Neurology and Clinical Investigation Center, CIC 1434, INSERM 1434, Strasbourg, France Hospital Universitario Virgen Macarena (G.I., S.E.), Sevilla, Spain CHU Pontchaillou (G.E.), CIC1414 INSERM, Rennes, France CHUM MS Center and Universite de Montreal (A.P., M.G.), Canada Dokuz Eylul University (S.O.), Konak/Izmir, Turkey CISSS Chaudière-Appalache (P.G.), Levis, Canada CHU Lille (H.Z.), CRCSEP Lille, Univ Lille, U1172, France CHU de Toulouse (J.C.), Hôpital Pierre-Paul Riquet, Department of Neurology, CRC-SEP, France Département de Neurologie (E.M.), Hôpital Pitié-Salpêtrière, APHP, Paris CHU de Dijon (T.M.), Department of Neurology, EA4184, France Department NEUROFARBA (M.P.A.), University of Florence, Italy CHU de Montpellier (P.L.), MS Unit, France University of Montpellier (MUSE) (P.L.), France Division of Neurology (Raed Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait Department of Neurology (K.B., O.S.), Box Hill Hospital, Melbourne, Australia Monash University (K.B., O.S.), Melbourne, Australia Melbourne MS Centre (K.B.), Royal Melbourne Hospital, Australia The Alfred Hospital (O.S.), Melbourne, Australia Medical Faculty (M.T.), 19 Mayis University, Samsun, Turkey CHU de Nantes (D.A.L.), Service de Neurologie & CIC015 INSERM, France CRTI-Inserm U1064 (D.A.L.), Nantes, France CHU de Besançon (E.B.), Service de Neurologie 25 030 Besançon, France Neuro Rive-Sud (F.G.M.), Quebec, Canada Neurology (C.L.-F.), UR2CA, Centre Hospitalier Universitaire Pasteur2, Université Nice Côte d'Azur, Nice, France UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy KTU Medical Faculty Farabi Hospital (C.B.), Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle, Australia Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia CHU Clermont-Ferrand (Pierre Clavelou), Department of Neurology Université Clermont Auvergne, Inserm, Neuro-Dol, Clermont-Ferrand, France Sorbonne Universités (B.S.), UPMC Paris 06, Brain and Spine Institute, ICM, Hôpital de La Pitié Salpêtrière, Inserm UMR S 1127, CNRS UMR 7225, and Department of Neurology, AP-HP, Saint-Antoine Hospital, Paris, France CSSS Saint-Jérôme (Julie Prevost), Saint-Jerome, Canada Neurologic Clinic and Policlinic (L.K.), Departments of Medicine and Clinical Research, University Hospital and University of Basel, Switzerland Aix Marseille Univ (Jean Pelletier), APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, France Isfahan University of Medical Sciences (V.S.), Iran Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y., S.J.K.), American University of Beirut Medical Center, Beirut, Lebanon Department of Neurology (Oliver Gerlach), Zuyderland Medical Center, Sittard-Geleen, Netherlands Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy Cliniques Universitaires Saint-Luc (V.V.P.), Université Catholique de Louvain, Brussels, Belgium Fondation Rotschild (Olivier Gout), Department of Neurology, Paris, France Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Hôpital de Poissy (O.H.), Department of Neurology, France Department of Neurology (E.T.), Nimes University Hospital, France Institut de Génomique Fonctionnelle (E.T.), UMR5203, INSERM 1191, Univ. Montpellier, France University of Queensland (P.A.M.), Brisbane, Australia Royal Brisbane and Women's Hospital (P.A.M.), Australia Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey CHU de Rouen (B.B.), Department of Neurology, France Flinders University (M.S.), Adelaide, Australia Instituto de Investigación Sanitaria Biodonostia (T.C.-T.), Hospital Universitario Donostia, San Sebastián, Spain CHU de Reims (S.B.), Department of Neurology, France Nemocnice Jihlava (Radek Ampapa), Czech Republic Monash Medical Centre (E.G.B.), Melbourne, Australia APHP (A.W.), Hôpital Henri Mondor, Department of Neurology, Créteil, France Austin Health (R.A.M.), Melbourne, Australia University Hospital Reina Sofia (E.A.-M.), Cordoba, Spain CHU de La Martinique (Philippe Cabre), Department of Neurology, Fort-de-France, France Hôpital Sud Francilien (N.H.B.), Department of Neurology, Corbeil Essonnes, France Department of Neurology (A.V.W., H.B.), The Alfred Hospital, Melbourne, Australia Central Clinical School (A.V.W., H.B.), Monash University, Melbourne, Australia Department of Neurology (G.L., L.V.H.), University Hospital Ghent, Belgium Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain CHU La Milétrie (N.M.), Hôpital Jean Bernard, Department of Neurology, Poitiers, France Liverpool Hospital (S.H.), Sydney, Australia Hospital de Galdakao-Usansolo (J.L.S.-M.), Spain Brain and Mind Centre (M.H.B.), Sydney, Australia CHU Bicêtre (C.L.), Department of Neurology, F-94275 Le Kremlin Bicêtre, France Westmead Hospital (Steve Vucic), Sydney, Australia Department of Neurology (Y.S., R.G.), Razi Hospital, Manouba, Tunisia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Hospital Universitari MútuaTerrassa (J.S.), Barcelona, Spain Groene Hart Ziekenhuis (K.G.), Gouda, Netherlands Sultan Qaboos University Hospital (A.A.-A.), Al-Khodh, Oman Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil Service de Neurologie (Sandra Vukusic), Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France Centre des Neurosciences de Lyon (Sandra Vukusic), Observatoire Français de La Sclérose en Plaques, INSERM 1028 et CNRS UMR5292, France and Université Claude Bernard Lyon 1 (Sandra Vukusic), Faculté de Médecine Lyon Est, France
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Izquierdo, Guillermo
Autor Izquierdo, Guillermo From the CORe (I.R., C.M., T.K.), Department of Medicine, University of Melbourne, Australia Melbourne MS Centre (I.R., C.M., T.K.), Department of Neurology, Royal Melbourne Hospital, Australia Rennes, University (E.L.), EHESP, REPERES EA 7449, France Univ Rennes (E.L.), CHU Rennes, Inserm, CIC 1414 ([Centre d'Investigation Clinique de Rennes]), France Université de Lyon (R.C.), Université Claude Bernard Lyon 1, France Hospices Civils de Lyon (R.C.), Service de Neurologie, Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Bron, France Observatoire Français de La Sclérose en Plaques (R.C.), Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, France Eugène Devic EDMUS Foundation Against Multiple Sclerosis (R.C.), State-approved Foundation, Bron, France Department of Neurology and Center of Clinical Neuroscience (D.H., E.K.H.), First Faculty of Medicine, Charles University in Prague and General University Hospital, Czech Republic Nancy University Hospital (M.D.), Department of Neurology, Nancy, France Université de Lorraine (M.D.), APEMAC, Nancy, France Department of Medical and Surgical Sciences and Advanced Technologies (F.P.), GF Ingrassia, Catania, Italy Multiple Sclerosis Center (F.P.), University of Catania, Italy CHU de Strasbourg (J.D.S.), Department of Neurology and Clinical Investigation Center, CIC 1434, INSERM 1434, Strasbourg, France Hospital Universitario Virgen Macarena (G.I., S.E.), Sevilla, Spain CHU Pontchaillou (G.E.), CIC1414 INSERM, Rennes, France CHUM MS Center and Universite de Montreal (A.P., M.G.), Canada Dokuz Eylul University (S.O.), Konak/Izmir, Turkey CISSS Chaudière-Appalache (P.G.), Levis, Canada CHU Lille (H.Z.), CRCSEP Lille, Univ Lille, U1172, France CHU de Toulouse (J.C.), Hôpital Pierre-Paul Riquet, Department of Neurology, CRC-SEP, France Département de Neurologie (E.M.), Hôpital Pitié-Salpêtrière, APHP, Paris CHU de Dijon (T.M.), Department of Neurology, EA4184, France Department NEUROFARBA (M.P.A.), University of Florence, Italy CHU de Montpellier (P.L.), MS Unit, France University of Montpellier (MUSE) (P.L.), France Division of Neurology (Raed Alroughani), Department of Medicine, Amiri Hospital, Sharq, Kuwait Department of Neurology (K.B., O.S.), Box Hill Hospital, Melbourne, Australia Monash University (K.B., O.S.), Melbourne, Australia Melbourne MS Centre (K.B.), Royal Melbourne Hospital, Australia The Alfred Hospital (O.S.), Melbourne, Australia Medical Faculty (M.T.), 19 Mayis University, Samsun, Turkey CHU de Nantes (D.A.L.), Service de Neurologie & CIC015 INSERM, France CRTI-Inserm U1064 (D.A.L.), Nantes, France CHU de Besançon (E.B.), Service de Neurologie 25 030 Besançon, France Neuro Rive-Sud (F.G.M.), Quebec, Canada Neurology (C.L.-F.), UR2CA, Centre Hospitalier Universitaire Pasteur2, Université Nice Côte d'Azur, Nice, France UOC Neurologia (E.C.), Azienda Sanitaria Unica Regionale Marche-AV3, Macerata, Italy KTU Medical Faculty Farabi Hospital (C.B.), Trabzon, Turkey School of Medicine and Public Health (J.L.-S.), University Newcastle, Australia Department of Neurology (J.L.-S.), John Hunter Hospital, Hunter New England Health, Newcastle, Australia CHU Clermont-Ferrand (Pierre Clavelou), Department of Neurology Université Clermont Auvergne, Inserm, Neuro-Dol, Clermont-Ferrand, France Sorbonne Universités (B.S.), UPMC Paris 06, Brain and Spine Institute, ICM, Hôpital de La Pitié Salpêtrière, Inserm UMR S 1127, CNRS UMR 7225, and Department of Neurology, AP-HP, Saint-Antoine Hospital, Paris, France CSSS Saint-Jérôme (Julie Prevost), Saint-Jerome, Canada Neurologic Clinic and Policlinic (L.K.), Departments of Medicine and Clinical Research, University Hospital and University of Basel, Switzerland Aix Marseille Univ (Jean Pelletier), APHM, Hôpital de La Timone, Pôle de Neurosciences Cliniques, Service de Neurologie, France Isfahan University of Medical Sciences (V.S.), Iran Nehme and Therese Tohme Multiple Sclerosis Center (B.I.Y., S.J.K.), American University of Beirut Medical Center, Beirut, Lebanon Department of Neurology (Oliver Gerlach), Zuyderland Medical Center, Sittard-Geleen, Netherlands Azienda Ospedaliera di Rilievo Nazionale San Giuseppe Moscati Avellino (D.L.A.S.), Italy Cliniques Universitaires Saint-Luc (V.V.P.), Université Catholique de Louvain, Brussels, Belgium Fondation Rotschild (Olivier Gout), Department of Neurology, Paris, France Haydarpasa Numune Training and Research Hospital (R.T.), Istanbul, Turkey Hôpital de Poissy (O.H.), Department of Neurology, France Department of Neurology (E.T.), Nimes University Hospital, France Institut de Génomique Fonctionnelle (E.T.), UMR5203, INSERM 1191, Univ. Montpellier, France University of Queensland (P.A.M.), Brisbane, Australia Royal Brisbane and Women's Hospital (P.A.M.), Australia Bakirkoy Education and Research Hospital for Psychiatric and Neurological Diseases (A.S.), Istanbul, Turkey CHU de Rouen (B.B.), Department of Neurology, France Flinders University (M.S.), Adelaide, Australia Instituto de Investigación Sanitaria Biodonostia (T.C.-T.), Hospital Universitario Donostia, San Sebastián, Spain CHU de Reims (S.B.), Department of Neurology, France Nemocnice Jihlava (Radek Ampapa), Czech Republic Monash Medical Centre (E.G.B.), Melbourne, Australia APHP (A.W.), Hôpital Henri Mondor, Department of Neurology, Créteil, France Austin Health (R.A.M.), Melbourne, Australia University Hospital Reina Sofia (E.A.-M.), Cordoba, Spain CHU de La Martinique (Philippe Cabre), Department of Neurology, Fort-de-France, France Hôpital Sud Francilien (N.H.B.), Department of Neurology, Corbeil Essonnes, France Department of Neurology (A.V.W., H.B.), The Alfred Hospital, Melbourne, Australia Central Clinical School (A.V.W., H.B.), Monash University, Melbourne, Australia Department of Neurology (G.L., L.V.H.), University Hospital Ghent, Belgium Hospital Germans Trias I Pujol (C.M.R.-T.), Badalona, Spain CHU La Milétrie (N.M.), Hôpital Jean Bernard, Department of Neurology, Poitiers, France Liverpool Hospital (S.H.), Sydney, Australia Hospital de Galdakao-Usansolo (J.L.S.-M.), Spain Brain and Mind Centre (M.H.B.), Sydney, Australia CHU Bicêtre (C.L.), Department of Neurology, F-94275 Le Kremlin Bicêtre, France Westmead Hospital (Steve Vucic), Sydney, Australia Department of Neurology (Y.S., R.G.), Razi Hospital, Manouba, Tunisia Department of Neurology (T.C.), Faculty of Medicine, University of Debrecen, Hungary Hospital Universitari MútuaTerrassa (J.S.), Barcelona, Spain Groene Hart Ziekenhuis (K.G.), Gouda, Netherlands Sultan Qaboos University Hospital (A.A.-A.), Al-Khodh, Oman Universidade Metropolitana de Santos (Y.D.F.), Santos, Brazil Service de Neurologie (Sandra Vukusic), Sclérose en Plaques, Pathologies de La Myéline et Neuro-inflammation, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France Centre des Neurosciences de Lyon (Sandra Vukusic), Observatoire Français de La Sclérose en Plaques, INSERM 1028 et CNRS UMR5292, France and Université Claude Bernard Lyon 1 (Sandra Vukusic), Faculté de Médecine Lyon Est, France
BACKGROUND AND OBJECTIVES: To evaluate the rate of return of disease activity after cessation of multiple sclerosis (MS) disease-modifying therapy. METHODS: This was a retrospective cohort study from 2 large observational MS registries: MSBase and OFSEP. Patients with relapsing-remitting MS who had ceased a disease-modifying therapy and were followed up for the subsequent 12 months were included in the analysis. The primary study outcome was annualized relapse rate in the 12 months after disease-modifying therapy discontinuation stratified by patients who did, and did not, commence a subsequent therapy. The secondary endpoint was the predictors of first relapse and disability accumulation after treatment discontinuation. RESULTS: A total of 14,213 patients, with 18,029 eligible treatment discontinuation epochs, were identified for 7 therapies. Annualized rates of relapse (ARRs) started to increase 2 months after natalizumab cessation (month 2-4 ARR 0.47, 95% CI 0.43-0.51). Commencement of a subsequent therapy within 2-4 months reduced the magnitude of disease reactivation (mean ARR difference: 0.15, 0.08-0.22). After discontinuation of fingolimod, rates of relapse increased overall (month 1-2 ARR: 0.80, 0.70-0.89) and stabilized faster in patients who started a new therapy within 1-2 months (mean ARR difference: 0.14, -0.01 to 0.29). The magnitude of disease reactivation for other therapies was low but reduced further by commencement of another treatment 1-10 months after treatment discontinuation. Predictors of relapse were a higher relapse rate in the year before cessation, female sex, younger age, and higher EDSS score. Commencement of a subsequent therapy reduced both the risk of relapse (HR 0.76, 95% CI 0.72-0.81) and disability accumulation (0.73, 0.65-0.80). DISCUSSION: The rate of disease reactivation after treatment cessation differs among MS treatments, with the peaks of relapse activity ranging from 1 to 10 months in untreated cohorts that discontinued different therapies. These results suggest that untreated intervals should be minimized after stopping antitrafficking therapies (natalizumab and fingolimod). CLASSIFICATION OF EVIDENCE: This study provides Class III that disease reactivation occurs within months of discontinuation of MS disease-modifying therapies. The risk of disease activity is reduced by commencement of a subsequent therapy.
- MeSH
- fingolimod hydrochlorid terapeutické užití MeSH
- imunosupresiva škodlivé účinky MeSH
- lidé MeSH
- natalizumab terapeutické užití MeSH
- recidiva MeSH
- relabující-remitující roztroušená skleróza * farmakoterapie epidemiologie MeSH
- retrospektivní studie MeSH
- roztroušená skleróza * chemicky indukované MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- práce podpořená grantem MeSH
Health & Medicine (ProQuest) od 2008-01-01 do Před 1 rokem
Psychology Database (ProQuest) od 2008-01-01 do Před 1 rokem
PubMed
34536228
DOI
10.1007/s40263-021-00860-7
Knihovny.cz E-zdroje
INTRODUCTION: Natalizumab has proved to be more effective than fingolimod in reducing disease activity in relapsing-remitting multiple sclerosis (RRMS). Whether this association is universal for all patient groups remains to be determined. OBJECTIVE: The aim of this study was to compare the relative effectiveness of natalizumab and fingolimod in RRMS subgroups defined by the baseline demographic and clinical characteristics of interest. METHODS: Patients with RRMS who were given natalizumab or fingolimod were identified in a merged cohort from three international registries. Efficacy outcomes were compared across subgroups based on patients' sex, age, disease duration, Expanded Disability Status Scale (EDSS) score, and disease and magnetic resonance imaging (MRI) activity 12 months prior to treatment initiation. Study endpoints were number of relapses (analyzed with weighted negative binomial generalized linear model) and 6-month confirmed disability worsening and improvement events (weighted Cox proportional hazards model), recorded during study therapy. Each patient was weighted using inverse probability of treatment weighting based on propensity score. RESULTS: A total of 5148 patients (natalizumab 1989; fingolimod 3159) were included, with a mean ± standard deviation age at baseline of 38 ± 10 years, and the majority (72%) were women. The median on-treatment follow-up was 25 (quartiles 15-41) months. Natalizumab was associated with fewer relapses than fingolimod (incidence rate ratio [IRR]; 95% confidence interval [CI]) in women (0.76; 0.65-0.88); in those aged ≤ 38 years (0.64; 0.54-0.76); in those with disease duration ≤ 7 years (0.63; 0.53-0.76); in those with EDSS score < 4 (0.75; 0.64-0.88), < 6 (0.80; 0.70-0.91), and ≥ 6 (0.52; 0.31-0.86); and in patients with pre-baseline relapses (0.74; 0.64-0.86). A higher probability of confirmed disability improvement on natalizumab versus fingolimod (hazard ratio [HR]; 95% CI) was observed among women (1.36; 1.10-1.66); those aged > 38 years (1.34; 1.04-1.73); those with disease duration > 7 years (1.33; 1.01-1.74); those with EDSS score < 6 (1.21; 1.01-1.46) and ≥ 6 (1.93; 1.11-3.34); and patients with no new MRI lesion (1.73; 1.19-2.51). CONCLUSIONS: Overall, in women, younger patients, those with shorter disease durations, and patients with pre-treatment relapses, natalizumab was associated with a lower frequency of multiple sclerosis relapses than fingolimod. It was also associated with an increased chance of recovery from disability among most patients, particularly women and those with no recent MRI activity.
- MeSH
- dospělí MeSH
- fingolimod hydrochlorid terapeutické užití MeSH
- imunologické faktory terapeutické užití MeSH
- imunosupresiva terapeutické užití MeSH
- internacionalita * MeSH
- kohortové studie MeSH
- lidé středního věku MeSH
- lidé MeSH
- longitudinální studie MeSH
- následné studie MeSH
- natalizumab terapeutické užití MeSH
- registrace * MeSH
- relabující-remitující roztroušená skleróza diagnóza farmakoterapie epidemiologie MeSH
- sekundární prevence MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
BACKGROUND: Natalizumab and fingolimod were the first preparations recommended for disease breakthrough in priorly treated relapsing-remitting multiple sclerosis. Of three published head-to-head studies two showed that natalizumab is the more effective to prevent relapses and EDSS worsening. METHODS: By re-analyzing original published results from MSBase, France, and Denmark using uniform methodologies, we aimed at identifying the effects of differences in methodology, in the MS-populations, and at re-evaluating the differences in effectiveness between the two drugs. We gained access to copies of the individual amended databases and pooled all data. We used uniform inclusion/exclusion criteria and statistical methods with Inverse Probability Treatment Weighting. RESULTS: The pooled analyses comprised 968 natalizumab- and 1479 fingolimod treated patients. The on-treatment natalizumab/fingolimod relapse rate ratio was 0.77 (p=0.004). The hazard ratio (HR) for a first relapse was 0.82 (p=0.030), and the HR for sustained EDSS improvement was 1.4 (p=0.009). There were modest differences between each of the original published studies and the replication study, but the conclusions of the three original studies remained unchanged: in two of them natalizumab was more effective, but in the third there was no difference between natalizumab and fingolimod. CONCLUSION: The results were largely invariant to the epidemiological and statistical methods but differed between the MS populations. Generally, the advantage of natalizumab was confirmed.
- MeSH
- fingolimod hydrochlorid * terapeutické užití MeSH
- imunosupresiva terapeutické užití MeSH
- lidé MeSH
- natalizumab terapeutické užití MeSH
- registrace MeSH
- relabující-remitující roztroušená skleróza * farmakoterapie MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Roos, Izanne
- Leray, Emmanuelle
- Frascoli, Federico
-
Casey, Romain
Autor Casey, Romain Université de Lyon, Université Claude Bernard Lyon 1, Lyon, France/Hospices Civils de Lyon, Service de Neurologie, sclérose en plaques, pathologies de la myéline et neuro-inflammation, Bron, France/Observatoire Français de la Sclérose en Plaques, Centre de Recherche en Neurosciences de Lyon, INSERM 1028 et CNRS UMR 5292, Lyon, France/EUGENE DEVIC EDMUS Foundation Against Multiple Sclerosis, State-Approved Foundation, Bron, France
- Brown, J William L
- Horakova, Dana
- Havrdova, Eva Kubala
- Debouverie, Marc
- Trojano, Maria
- Patti, Francesco
PubMed
33423618
DOI
10.1177/1352458520981300
Knihovny.cz E-zdroje
BACKGROUND: A delayed onset of treatment effect, termed therapeutic lag, may influence the assessment of treatment response in some patient subgroups. OBJECTIVES: The objective of this study is to explore the associations of patient and disease characteristics with therapeutic lag on relapses and disability accumulation. METHODS: Data from MSBase, a multinational multiple sclerosis (MS) registry, and OFSEP, the French MS registry, were used. Patients diagnosed with MS, minimum 1 year of exposure to MS treatment and 3 years of pre-treatment follow-up, were included in the analysis. Studied outcomes were incidence of relapses and disability accumulation. Therapeutic lag was calculated using an objective, validated method in subgroups stratified by patient and disease characteristics. Therapeutic lag under specific circumstances was then estimated in subgroups defined by combinations of clinical and demographic determinants. RESULTS: High baseline disability scores, annualised relapse rate (ARR) ⩾ 1 and male sex were associated with longer therapeutic lag on disability progression in sufficiently populated groups: females with expanded disability status scale (EDSS) < 6 and ARR < 1 had mean lag of 26.6 weeks (95% CI = 18.2-34.9), males with EDSS < 6 and ARR < 1 31.0 weeks (95% CI = 25.3-36.8), females with EDSS < 6 and ARR ⩾ 1 44.8 weeks (95% CI = 24.5-65.1), and females with EDSS ⩾ 6 and ARR < 1 54.3 weeks (95% CI = 47.2-61.5). CONCLUSIONS: Pre-treatment EDSS and ARR are the most important determinants of therapeutic lag.
- MeSH
- lidé MeSH
- postižení * MeSH
- posuzování pracovní neschopnosti MeSH
- progrese nemoci MeSH
- recidiva MeSH
- registrace MeSH
- relabující-remitující roztroušená skleróza * MeSH
- roztroušená skleróza * farmakoterapie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
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