DNA interstrand cross-linking (ICL) agents are an important group of cytotoxic drugs with the capability of binding covalently between two strands of DNA, thereby preventing vital processes such as replication or transcription in dividing cells. In anticancer therapy however, their potential is limited due to the resistance by various mechanisms. In order to develop highly effective antitumor drugs it is necessary to study both effective ICL formations and their subsequent repair mechanisms. This review presents an overview of development over the past decade and the use of both well-known and new DNA interstrand cross-linking agents. Their potential in applications especially as anticancer chemotherapeutics in the framework of current knowledge of repair mechanisms and development of combined chemotherapy is discussed.
- MeSH
- alkaloidy chemie terapeutické užití MeSH
- anthrachinony chemie terapeutické užití MeSH
- antitumorózní látky chemie terapeutické užití MeSH
- azepiny chemie terapeutické užití MeSH
- aziridiny chemie terapeutické užití MeSH
- DNA chemie metabolismus MeSH
- komplexní sloučeniny chemie terapeutické užití MeSH
- lidé MeSH
- mechlorethamin chemie terapeutické užití MeSH
- nádory farmakoterapie MeSH
- oprava DNA MeSH
- reagencia zkříženě vázaná chemie terapeutické užití MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
