Our comprehensive study of the endometrium (hysteroscopic, morphological, and immunological research of genital infections) of patients with reproductive disorders has revealed a high frequency (73.8%) of hyperplastic processes of endometrium (endometrial hyperplasia, polyps), also in the most cases (73 8%) - infection of the endometrium with a predominance of microbial associations (78.6%) and mycoplasma infections (33.2%).

• MeSH
• Endometritis virology   MeSH
• Endometrium * anatomy & histology   microbiology   pathology   MeSH
• Genital Diseases, Female * MeSH
• Endometrial Hyperplasia * MeSH
• Humans MeSH
• Lymphocytes MeSH
• Mycoplasma Infections MeSH
• Infertility, Female etiology   MeSH
• Check Tag
• Humans MeSH
• Female MeSH

Examination of immunity disorders at the system and local levels in pregnant women with persistent mycoplasma infection has been carried out. The analysis has revealed depression of circulating in blood CD3 and CD4 , increase of CD16 and CD19 , decrease of activated CD25 and ready to adaptation CD95 lymphocytes. Studies of the concentration of cytokines at the local level (cervical mucus) in pregnant women with mycoplasma infection showed a significant increase in concentrations of both proinflammatory (TNF-ά, IL-6) and anti-inflammatory (IL-4 in 4.5 times) cytokines compared with controls group (P <0.05 and P <0.01), which confirms the presence of an inflammatory process not only at the system level, but locally. That means that pregnant women with mycoplasma infection in comparison with healthy pregnant women were indicated with violations of the regulation system of cytokines in peripheral blood and locally in the cervical mucus. It is characterized by increased TH-1 cell response to the increasing fusion of pro-inflammatory cytokines (IL-1, IL-6, IFN-γ, TNF-ά), and pointed to the imbalance of their products, which may be a factor in this pregnancy complication.

• MeSH
• Blood Chemical Analysis MeSH
• Pregnancy Trimester, Second MeSH
• Phagocytosis MeSH
• Immune System pathology   MeSH
• Immunophenotyping MeSH
• Pregnancy Complications, Infectious * diagnosis   immunology   pathology   MeSH
• Humans MeSH
• Lymphocytes physiology   MeSH
• Mycoplasma Infections * diagnosis   immunology   blood   MeSH
• Flow Cytometry utilization   MeSH
• T-Lymphocytes physiology   MeSH
• Pregnancy MeSH
• Pregnancy Trimester, Third MeSH
• Check Tag
• Humans MeSH
• Pregnancy MeSH
• Female MeSH