• Publikační typ
• abstrakt z konference MeSH

The aim of this study was to reveal the effects of foodborne fluoxetine on morphological and condition profile, hematological profile, biochemical and oxidative stress indices on juvenile rainbow trout. The study was performed according to OECD Guideline No. 215. Fluoxetine was incorporated into Biomar 921 pellets at a dose of 0.047 mg/kg (environmental concentration), 0.577 mg/kg and 6.7 mg/kg. There was statistically significant change in hematological profile, including an increasing trend in neutrophil/lymphocyte ratio and a decreasing trend in the number of lymphocytes. Measurements of oxidative stress indicated decreased activity of the detoxifying enzyme glutathione-S-transferase in the liver and kidney. However, the measurement of GR, GPx, CAT, SOD activity, and TBARS showed no changes. Histopathological examination revealed damage to the proximal tubules of caudal kidney in exposed groups. This study confirms that fluoxetine has a significant effect on immune response.

• MeSH
• antidepresiva druhé generace toxicita   MeSH
• chemické látky znečišťující vodu toxicita   MeSH
• fluoxetin toxicita   MeSH
• imunita účinky léků   MeSH
• kontaminace potravin MeSH
• krevní obraz MeSH
• krmivo pro zvířata MeSH
• Oncorhynchus mykiss krev   imunologie   MeSH
• oxidační stres účinky léků   MeSH
• proximální tubuly ledvin účinky léků   MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH