BACKGROUND/OBJECTIVE: Obesity is an alarming threat for all age groups, including children. Fat overconsumption is one of the factors that directly influences this pathology. Recent studies have suggested that a common variant in the CD36 gene, that is, single-nucleotide polymorphism (SNP) rs1761667-A allele, that reduces CD36 expression, associates with high oral fat detection thresholds in some obese subjects. The objective was to assess fatty acid sensitivity in relation to CD36 SNP in young lean and obese children. SUBJECTS/METHODS: We studied lingual detection thresholds for emulsions, containing oleic acid, in Algerian children (n=116, age=8±0.5 years) who were divided into two groups: obese (n=57; body mass index (BMI) z-score=2.513±0.490) and lean children (n=59; BMI z-score=-0.138±0.601) by alternative-forced choice method. To correlate the lipid taste perception thresholds with CD36 SNP, the children were genotyped for A/G SNP rs1761667 in 5'UTR region of CD36 by using PCR and restriction fragment length polymorphism. RESULTS: We noticed significantly higher CD36 A-allele frequency (P=0.036) in young obese children compared with leans. CD36 A-allele was associated with higher lipid taste perception thresholds than G-allele in obese children, but not in lean controls. Moreover, waist circumference was positively correlated with reduced fat taste sensitivity in these children. CONCLUSIONS: CD36 SNP A-allele, being present both in young lean and in obese children, is associated with high threshold for fatty acid taste sensitivity only in obese children.
- MeSH
- antigeny CD36 genetika MeSH
- chuťová percepce genetika MeSH
- dietní tuky MeSH
- dítě MeSH
- frekvence genu MeSH
- genotyp MeSH
- hubenost genetika metabolismus MeSH
- index tělesné hmotnosti MeSH
- jednonukleotidový polymorfismus * MeSH
- kyselina olejová metabolismus MeSH
- lidé MeSH
- obezita genetika metabolismus MeSH
- obvod pasu MeSH
- preference v jídle MeSH
- průzkumy a dotazníky MeSH
- stravovací zvyklosti MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Alžírsko MeSH
- Publikační typ
- abstrakt z konference MeSH
Byl popsán nehodgkinský maligní lymfom velkobuněčný B bohatý na T lymfocyty u pacientky s ložisky v levém prsu a v pravé orbitě, dále se suspektními kožními ložisky a zvětšenými uzlinami v mediastinu dle počítačové tomografie. Diferenciálně diagnosticky jsme podle průběhu onemocnění mimo maligního lymfomu uvažovali i o orbitocelulitidě či pseudotumoru orbity. Zvláštností je, že se pacientka již léčila pro mnohočetný myelom. Důraz je kladen na komplexní léčbu pacientky s nutností konziliárních vyšetření medicínských oborů s tímto onemocněním spjatých. Po radioterapii došlo u pacientky k totální regresi orbitálního nálezu.
The authors describe a non-Hodgkin malignant large-cellBlymphomawith ample lymphocytes in a female patient with foci in the left breast and right orbit, with suspect skin foci and enlarged nodes in the mediastinum as revealed by computed tomography. In the differential diagnosis the authors reflected according to the course of the disease in addition to malignant lymphoma also on orbitocellulitis or a pseudotumourof the orbit.Theremarkable feature is thatthepatienthadalreadytreatment on account of a multiple myeloma. The authors emphasize comprehensive treatment of the patient and the necessity of consultations with specialist of other medical disciplines associated with this disease. After radiotherapy total regression of the orbital finding occurred in the patient.
- MeSH
- diferenciální diagnóza MeSH
- lidé MeSH
- lymfom diagnóza radioterapie terapie MeSH
- nádory orbity diagnóza radioterapie terapie MeSH
- senioři MeSH
- Check Tag
- lidé MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
