Colorectal cancer (CRC) is the third most frequent malignant disease in developed countries. A large number of studies have been undertaken to identify potential risk factors for cancer, amongst which the association with trace elements, such as zinc, found naturally in the environment, and whose human exposure derives from a variety of sources. Significant alterations in Zn(II) levels in tissues have previously been reported in patients with various forms of cancer. Moreover, low plasma Zn(II) levels have been observed in patients with cancer of the colon, bronchus or digestive system. In this review, we focus largely on the association between zinc noted above and risk of CRC. Intervention plan in this type of cancer needs to consider nutritional responses towards anti-cancer drugs based on their biological and genetic characteristics, furthermore, a possible association with zinc in cancer treatment also requires attention. The analysis of Zn biomarkers levels could provide new biological insights applied in prevention, molecular diagnosis, prognosis and treatment of CRC.
- MeSH
- kolorektální nádory * enzymologie etiologie krev MeSH
- lidé MeSH
- metalothionein MeSH
- nádorové biomarkery * krev MeSH
- oxidační stres MeSH
- stopové prvky MeSH
- střevní sliznice enzymologie MeSH
- transportní proteiny MeSH
- zánět MeSH
- zinek * krev metabolismus MeSH
- zinkové prsty genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
