The Banff Working Group on Liver Allograft Pathology reviewed and discussed literature evidence regarding antibody-mediated liver allograft rejection at the 11th (Paris, France, June 5-10, 2011), 12th (Comandatuba, Brazil, August 19-23, 2013), and 13th (Vancouver, British Columbia, Canada, October 5-10, 2015) meetings of the Banff Conference on Allograft Pathology. Discussion continued online. The primary goal was to introduce guidelines and consensus criteria for the diagnosis of liver allograft antibody-mediated rejection and provide a comprehensive update of all Banff Schema recommendations. Included are new recommendations for complement component 4d tissue staining and interpretation, staging liver allograft fibrosis, and findings related to immunosuppression minimization. In an effort to create a single reference document, previous unchanged criteria are also included.
- MeSH
- alografty MeSH
- isoprotilátky imunologie MeSH
- lidé MeSH
- rejekce štěpu etiologie patologie MeSH
- transplantace jater škodlivé účinky MeSH
- výzkumná zpráva MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Congenital forms of hearing impairment can be caused by mutations in the estrogen related receptor beta (ESRRB) gene. Our initial linkage studies suggested the ESRRB locus is linked to high caries experience in humans. METHODS: We tested for association between the ESRRB locus and dental caries in 1,731 subjects, if ESRRB was expressed in whole saliva, if ESRRB was associated with the microhardness of the dental enamel, and if ESRRB was expressed during enamel development of mice. RESULTS: Two families with recessive ESRRB mutations and DFNB35 hearing impairment showed more extensive dental destruction by caries. Expression levels of ESRRB in whole saliva samples showed differences depending on sex and dental caries experience. CONCLUSIONS: The common etiology of dental caries and hearing impairment provides a venue to assist in the identification of individuals at risk to either condition and provides options for the development of new caries prevention strategies, if the associated ESRRB genetic variants are correlated with efficacy.
- MeSH
- demineralizace zubů * genetika MeSH
- dítě MeSH
- dospělí MeSH
- genetické asociační studie MeSH
- jednonukleotidový polymorfismus MeSH
- lidé MeSH
- lidské chromozomy, pár 14 MeSH
- mladiství MeSH
- mladý dospělý MeSH
- myši MeSH
- nádorové buněčné linie MeSH
- percepční nedoslýchavost genetika patologie MeSH
- předškolní dítě MeSH
- receptory pro estrogeny fyziologie genetika MeSH
- rodokmen MeSH
- vazebná nerovnováha MeSH
- zubní kaz * genetika MeSH
- zubní sklovina růst a vývoj MeSH
- zvířata MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- myši MeSH
- předškolní dítě MeSH
- ženské pohlaví MeSH
- zvířata MeSH
