Bile acids are compounds with many functions in liver and other parts of gastrointestinal tract. Apart from long-known ability of bile acids to form micelles and help with both intestinal digestion and absorption of lipids, other (but not less important) properties of these molecules are still neglected. Among pleitropic effects of bile acids belong regulation of cholesterol homeostasis, antimicrobial properties and novel functions discovered in last decades. It seems that the notion of bile acids as compounds important mainly for their physico-chemical properties should be reevaluated and we have to put stress on the importance of bile acids as structures with hormonal functions. Moreover, the molecules of bile acids have unusual properties, which predetermine them for attractive drug designs, as vectors for delivery of active substances, production of chiral compounds, dendrons, or even photoresistant molecules for microcircuits.
- MeSH
- antivirové látky MeSH
- biologické markery MeSH
- dendrimery MeSH
- kationické antimikrobiální peptidy izolace a purifikace MeSH
- nanočástice MeSH
- nosiče léků MeSH
- Squalus MeSH
- vztahy mezi strukturou a aktivitou MeSH
- žlučové kyseliny a soli * farmakologie metabolismus terapeutické užití MeSH
- Publikační typ
- práce podpořená grantem MeSH
A new species of tetraphyllidean cestode in the genus Trilocularia is described from an undescribed shark species, Squalus cf. mitsukurii, off the coast of South Africa. Trilocularia eberti sp. n. is the second known member of its genus, and like its congener, T. gracilis (Olsson, 1866–1867) Olsson, 1869, is extremely hyperapolytic, dropping proglottids from its strobila while they are still very immature. Characteristic of the genus, it possesses a distinctive scolex with triloculated bothridia, but differs conspicuously from its congener in its possession of an anterior loculus that is much larger in width relative to the paired posterior loculi, and also in its possession of an anterior, enlarged region of its free proglottids that is triangular with a slit-like ventral aperture, rather than rounded and cup-like. This anterior region of the free proglottid is used in attachment, and its development is described. For assessment of fecundity, an attempt was made to record all free proglottids of all ages found in both host individuals, and yielded an average estimate of 362 free proglottids being produced per individual worm of T. eberti sp. n. Both Trilocularia species parasitize sharks of the genus Squalus, and given the host specificity typically exhibited by tetraphyllideans and preliminary examinations of other members of this shark genus, it is likely that other Squalus species will be found to host additional new Trilocularia species.
- MeSH
- Cestoda anatomie a histologie fyziologie klasifikace MeSH
- cestodózy epidemiologie parazitologie veterinární MeSH
- fertilita MeSH
- mikroskopie elektronová rastrovací veterinární MeSH
- nemoci ryb epidemiologie parazitologie MeSH
- oceány a moře MeSH
- rozmnožování fyziologie MeSH
- Squalus parazitologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
- Geografické názvy
- Jihoafrická republika MeSH
- oceány a moře MeSH
