The present study was conducted to evaluate the methanolic extracts from several plant leaves widely used in traditional medicine to cure digestive tract disorders and in the self-medication of wild animals such as non-human primates, namely Archidendron fagifolium, Diospyros sumatrana, Shorea sumatrana, and Piper betle leaves, with regard to their antimicrosporidial activity against Encephalitozoon cuniculi in immunocompetent BALB/c mice determined using molecular detection of microsporidial DNA (qPCR) in various tissues and body fluids of infected, treated mice. Of the plant extracts tested, Diospyros sumatrana provided the most promising results, reducing spore shedding by 88% compared to untreated controls. Moreover, total burden per 1 g of tissue in the D. sumatrana extract-treated group reached 87% reduction compared to untreated controls, which was comparable to the effect of the standard drug, Albendazole. This data represents the baseline necessary for further research focused on determining the structure, activity and modes of action of the active compounds, mainly of D. sumatrana, enabling subsequent development of antimicrosporidial remedies.
- MeSH
- albendazol farmakologie terapeutické užití MeSH
- antifungální látky farmakologie terapeutické užití MeSH
- Cercopithecus aethiops MeSH
- dimethylsulfoxid farmakologie terapeutické užití MeSH
- Diospyros chemie MeSH
- Dipterocarpaceae chemie MeSH
- DNA fungální izolace a purifikace MeSH
- Encephalitozoon cuniculi účinky léků MeSH
- encephalitozoonóza farmakoterapie MeSH
- Fabaceae chemie MeSH
- feces parazitologie MeSH
- gastrointestinální trakt mikrobiologie MeSH
- imunokompetence MeSH
- listy rostlin chemie MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- Piper betle chemie MeSH
- rostlinné extrakty farmakologie terapeutické užití MeSH
- spory hub účinky léků MeSH
- Vero buňky MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Indonésie MeSH
