The reactivating and therapeutic efficacy of two newly developed oximes (K305, K307) was compared with the oxime K203 and trimedoxime using in vivo methods The study determining percentage of reactivation of tabun-inhibited acetylcholinesterase in the peripheral as well as central nervous system (diaphragm, brain) in tabun-poisoned rats showed that the reactivating efficacy of both newly developed oximes is lower compared to the reactivating efficacy of the oxime K203 and trimedoxime. The therapeutic efficacy of all oximes studied roughly corresponds to their reactivating efficacy. While the ability of the oxime K305 to reduce acute toxicity of tabun in mice is approaching to the therapeutic efficacy of trimedoxime, the ability of another novel bispyridinium oxime K307 to reduce acute toxicity of tabun is significantly lower compared to trimedoxime and the oxime K203. Thus, the reactivating and therapeutic efficacy of both examined newly developed oximes does not prevail the effectiveness of the oxime K203 and trimedoxime and, therefore, they are not suitable for their replacement of commonly used oximes for the treatment of acute tabun poisoning.

• MeSH
• Acetylcholinesterase drug effects   MeSH
• Antidotes administration & dosage   pharmacology   toxicity   MeSH
• Atropine administration & dosage   pharmacology   toxicity   MeSH
• Diaphragm enzymology   MeSH
• Models, Animal MeSH
• Brain enzymology   drug effects   MeSH
• Mice, Mutant Strains MeSH
• Nerve Agents pharmacology   chemistry   toxicity   MeSH
• Organophosphates pharmacology   toxicity   MeSH
• Oximes * pharmacology   chemistry   classification   MeSH
• Rats, Wistar MeSH
• Cholinesterase Reactivators administration & dosage   pharmacology   toxicity   MeSH
• Trimedoxime pharmacology   chemistry   classification   MeSH
• Animals MeSH
• Check Tag
• Male MeSH
• Animals MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH