BACKGROUND: Our aim was to identify the number of cases of secretory carcinoma (SC) of the major salivary gland in a population-based cohort and review its clinical behavior with long-term follow-up. METHODS: All malignant salivary gland tumors (MSGTs) diagnosed between 1980 and 2014 were assessed for histological features compatible with SC and 140 were selected for further analysis. RESULTS: Twenty two new cases of SC were identified, 19 of which were originally classified as acinic cell carcinoma, and 3 as adenocarcinoma, not otherwise specified (NOS). Lymph node involvement was less common in SC tumors (5%) than in the control group (11%). Disease recurrence was seen less frequently in SC (9%) than the control group (20%). Mean disease-free survival was 192 months for SC compared with 162 months for controls (P = 0.15). CONCLUSION: The clinical course of SC is typically indolent with a low risk of relapse not significantly different from other low-grade MSGT.

• MeSH
• acinární karcinom epidemiologie   patologie   MeSH
• adenokarcinom epidemiologie   patologie   MeSH
• analýza přežití MeSH
• dospělí MeSH
• karcinom * epidemiologie   patologie   terapie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory slinných žláz * epidemiologie   patologie   terapie   MeSH
• následné studie MeSH
• registrace MeSH
• retrospektivní studie MeSH
• studie případů a kontrol MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH

Epidemiologic and clinicopathologic features, therapeutic strategies, and prognosis for acinic cell carcinoma of the major and minor salivary glands are critically reviewed. We explore histopathologic, histochemical, electron microscopic and immunohistochemical aspects and discuss histologic grading, histogenesis, animal models, and genetic events. In the context of possible diagnostic difficulties, the relationship to mammary analog secretory carcinoma is probed and a classification is suggested. Areas of controversy or uncertainty, which may benefit from further investigations, are also highlighted.

• MeSH
• acinární karcinom * epidemiologie   metabolismus   patologie   terapie   MeSH
• diferenciální diagnóza MeSH
• elektronová mikroskopie MeSH
• lidé MeSH
• malé slinné žlázy MeSH
• modely nemocí na zvířatech MeSH
• nádory slinných žláz epidemiologie   metabolismus   patologie   terapie   MeSH
• parotis MeSH
• předoperační péče MeSH
• prognóza MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH