Artiodactyls possess GALT that appears in fetal life and is located at the extreme end of the ileum. These IPP contain mostly B cells and involute early in postnatal life. Rabbits have a similarly located lymphoid organ, called the sacculus rotundus. Studies in sheep and rabbits have led to the concept that the lower hindgut GALT represents primary lymphoid tissue for B cells and is necessary for normal B cell development, analogous to the bursa of Fabricius. This review traces the history of the observations and theories that have led to the existing concept concerning the role of lower GALT. We then review recent data from piglets with resected IPP that challenges the concept that the IPP is primary B cell lymphoid tissue and that artiodactyls and rabbits are members of the GALT group in the same context as gallinaceous birds. Eliminating the IPP as the primary lymphoid tissue for B cells leads to the hypothesis that the IPP acts as first-responder mucosal lymphoid tissue.

• MeSH
• apoptóza MeSH
• Artiodactyla imunologie   MeSH
• B-lymfocyty cytologie   imunologie   MeSH
• buněčný rodokmen MeSH
• bursa Fabricii cytologie   imunologie   chirurgie   MeSH
• druhová specificita MeSH
• gnotobiologické modely MeSH
• imunitní systém embryologie   růst a vývoj   MeSH
• králíci imunologie   MeSH
• kur domácí imunologie   MeSH
• lidé MeSH
• lymfatické uzliny cytologie   imunologie   MeSH
• lymfoidní tkáň cytologie   imunologie   chirurgie   MeSH
• lymfopoéza MeSH
• mezenterium imunologie   MeSH
• modely imunologické MeSH
• Peyerovy pláty cytologie   imunologie   chirurgie   MeSH
• prasata imunologie   MeSH
• savci embryologie   imunologie   MeSH
• střeva imunologie   MeSH
• střevní sliznice embryologie   růst a vývoj   imunologie   MeSH
• tvorba protilátek MeSH
• zvířata MeSH
• Check Tag
• králíci imunologie   MeSH
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH