OBJECTIVES: The aim of the study was to analyze polymorphisms of receptor for advanced glycation end products (RAGE) gene, and glyoxalase I gene and soluble RAGE, sRAGE, in physiological and pathological pregnancy. DESIGN AND METHODS: Polymorphisms of RAGE gene (-429 T/C, -374 T/A, 557 G/A, 2184 A/G) and glyoxalase I gene (A419C) and sRAGE serum levels were determined in 284 women with pathological and physiological pregnancy. RESULTS: No differences in distribution of genotype and allelic frequencies of studied polymorphisms were found. GA genotype of RAGE 557 G/A polymorphism (known as Gly82Ser) is associated with lower sRAGE serum levels in healthy pregnant women compared to GG genotype (483 ± 104 vs. 692 ± 262 pg/mL, p=0.008). sRAGE correlates negatively with ALT in patients with pregnancy intrahepatic cholestasis (r=-0.536, p=0.05). CONCLUSIONS: We did not show any association of RAGE and glyoxalase I gene polymorphisms with pathological pregnancy, however further studies are needed to confirm the results.
- MeSH
- alanintransaminasa krev MeSH
- antigeny nádorové krev genetika MeSH
- biologické markery krev MeSH
- dospělí MeSH
- frekvence genu MeSH
- genetické asociační studie MeSH
- intrahepatální cholestáza krev genetika MeSH
- jednonukleotidový polymorfismus * MeSH
- komplikace těhotenství krev genetika MeSH
- laktoylglutathionlyasa genetika MeSH
- lidé MeSH
- mitogenem aktivované proteinkinasy krev genetika MeSH
- předčasná porodní činnost krev genetika MeSH
- preeklampsie krev genetika MeSH
- růstová retardace plodu krev genetika MeSH
- sekvenční analýza DNA MeSH
- studie případů a kontrol MeSH
- těhotenství MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
