This review comprehensively describes the recent advances in the synthesis and pharmacological evaluation of steroid polyamines squalamine, trodusquemine, ceragenins, claramine, and their diverse analogs and derivatives, with a special focus on their complete synthesis from cholic acids, as well as an antibacterial and antiviral, neuroprotective, antiangiogenic, antitumor, antiobesity and weight-loss activity, antiatherogenic, regenerative, and anxiolytic properties. Trodusquemine is the most-studied small-molecule allosteric PTP1B inhibitor. The discovery of squalamine as the first representative of a previously unknown class of natural antibiotics of animal origin stimulated extensive research of terpenoids (especially triterpenoids) comprising polyamine fragments. During the last decade, this new class of biologically active semisynthetic natural product derivatives demonstrated the possibility to form supramolecular networks, which opens up many possibilities for the use of such structures for drug delivery systems in serum or other body fluids.
- MeSH
- antiinfekční látky chemická syntéza chemie farmakologie MeSH
- biologické přípravky chemie farmakologie MeSH
- cholestanoly chemie MeSH
- cholestany chemie MeSH
- inhibitory angiogeneze chemická syntéza chemie farmakologie MeSH
- lidé MeSH
- neuroprotektivní látky chemická syntéza chemie farmakologie MeSH
- protinádorové látky chemická syntéza chemie farmakologie MeSH
- spermin analogy a deriváty chemie MeSH
- steroidy chemická syntéza chemie farmakologie MeSH
- triterpeny chemická syntéza chemie farmakologie MeSH
- vodní organismy chemie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
A new ELISA method of analysis of N,N?-diacetylspermine in urine and a test for urinary bladder cancer were developed and validated. However, the compound does not seem to be a useful marker for urinary bladder cancer.
- MeSH
- diagnostické techniky urologické přístrojové vybavení využití MeSH
- ELISA dějiny metody využití MeSH
- klinické laboratorní techniky přístrojové vybavení využití MeSH
- klinické zkoušky jako téma metody využití MeSH
- lidé MeSH
- nádory močového měchýře diagnóza moč MeSH
- spermin analogy a deriváty moč MeSH
- statistika jako téma MeSH
- Check Tag
- lidé MeSH
BACKGROUND: N1,N12-diacetylspermine, a diacetylpolyamine which was recently identified in urine, appeared to be a useful tumor marker for a number of cancers. No valid data on urine diacetylspermine concentration in patients with urinary bladder cancer exist. AIM: Evaluation of urine N1,N12-diacetylspermine concentrations in individuals with urinary bladder cancer. METHODS: Urine samples were used from 36 patients with urothelial tumors of the urinary bladder and from 30 patients with benign urological diseases. Urine was collected before cystoscopy. Enzyme-linked immunoabsorbent assays (ELISA) were performed for diacetylspermine from urine. RESULTS: Urine diacetylspermine did not differentiate in individuals with urinary bladder cancer from controls (medians 171.5 vs 143.8, p = 0.64). Its efficacy for urinary bladder cancer detection was not shown. CONCLUSIONS: Urine N1,N12-diacetylspermine is probably not a useful marker for urinary bladder cancer.
[4] s. ; 24 cm
- Klíčová slova
- Neospermin,
- MeSH
- metabolické nemoci farmakoterapie MeSH
- nemoci ledvin farmakoterapie MeSH
- nemoci nervového systému farmakoterapie MeSH
- nemoci srdce farmakoterapie MeSH
- plicní nemoci farmakoterapie MeSH
- rekonvalescence MeSH
- spermin analogy a deriváty terapeutické užití MeSH
- Publikační typ
- informační letáky pro pacienty MeSH
- Konspekt
- Farmacie. Farmakologie
- NLK Obory
- farmacie a farmakologie
