The aim of this review was to summarize recent knowledge of the structure and function of a transcriptional repressor, B lymphocyte induced maturation protein 1 (BLIMP1) and its participation in the pathogenesis of B lymphomas. Methods and results. This review summarizes the structure and function of BLIMP1, its major target genes and its role as a tumour suppressor in B cell lymphomas. We review our recent data implicating the loss of BLIMP1α as an important step in the pathogenesis of the Epstein-Barr virus (EBV) associated B cell lymphomas. Conclusions. BLIMP1 is a transcriptional repressor essential for the differentiation of germinal centre (GC) B cells to plasma cells. The loss of BLIMP1 in GC B cells could contribute to the pathogenesis of EBV-associated lymphomas by preventing plasma cell differentiation and viral replication.
- MeSH
- B-buněčný lymfom genetika virologie MeSH
- buněčná diferenciace genetika MeSH
- down regulace MeSH
- imunoglobuliny biosyntéza MeSH
- lidé MeSH
- plazmatické buňky fyziologie MeSH
- regulace genové exprese u nádorů MeSH
- represorové proteiny fyziologie genetika MeSH
- tumor supresorové geny fyziologie MeSH
- virus Epsteinův-Barrové fyziologie MeSH
- zárodečné centrum lymfatické uzliny fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
