Kazuistika demonstruje užití hypnózy v psychoterapii (PST) jako hlavní metody v léčbě specifické (izolované) fobie, aviafobie. V příspěvku je podrobně popsána část PST, která je zaměřena na fobii a připravuje pacientku na let letadlem. Konkrétně se jedná o pět sezení, ve kterých byla 3× aplikována hypnóza. V době mezi sezeními praktikovala klientka též nácvik autogenního tréninku (AT) a pracovala s autosugescemi. Po úspěšném zvládnutí letu došlo k pokračování PST s následně dohodnutou pauzou, která však byla faktickým ukončením terapie. Kazuistika ukazuje vysokou účinnost hypnoticko-sugestivních metod v krátkém čase.

The case report demonstrates the use of hypnosis in psychotherapy (PST) as the principal method in treating a specific (isolated) phobia, aviophobia. The article describes in detail the part of PST that is focused on a phobia and prepares a patient for air travel. Specifically, there were five sessions in which hypnosis was used three times. In between the sessions, the client also practised autogenic training and worked with autosuggestions. After she had flown successfully, PST was resumed and then a pause was agreed on, which, in fact, turned out to be termination of the therapy. The case report shows a high efficacy of hypnotic-suggestive methods in a short time period.

• Keywords
• aviafobie,
• MeSH
• Autogenic Training methods   MeSH
• Autosuggestion MeSH
• Air Travel psychology   MeSH
• Adult MeSH
• Phobic Disorders * etiology   therapy   MeSH
• Hypnosis * methods   MeSH
• Humans MeSH
• Psychotherapy methods   MeSH
• Suggestion MeSH
• Check Tag
• Adult MeSH
• Humans MeSH
• Female MeSH
• Publication type
• Case Reports MeSH

• MeSH
• Medication Adherence statistics & numerical data   MeSH
• Antipsychotic Agents administration & dosage   adverse effects   MeSH
• Drug Therapy methods   MeSH
• Clinical Decision-Making MeSH
• Drug Interactions MeSH
• Humans MeSH
• Young Adult MeSH
• Olanzapine administration & dosage   MeSH
• Schizophrenia * drug therapy   therapy   MeSH
• Body Weight drug effects   MeSH
• Check Tag
• Humans MeSH
• Young Adult MeSH
• Publication type
• Case Reports MeSH

OBJECTIVE: Patients with chronic idiopathic intracranial hypertension (IIH) commonly experience a high level of disability and low satisfaction with medical treatment. We aim to evaluate long-term functional improvement and patient satisfaction in IIH patients with similar symptoms by comparing venous sinus stenting (VSS) to standard medical therapy. METHODS: We conducted a cross-sectional questionnaire study of 111 IIH patients, comparing 37 adult female patients who underwent venous sinus stenting with 74 patients treated medically. Propensity score matching was used to balance age and presence of papilledema at presentation between groups. Headache-related disability was evaluated using the Migraine Disability Assessment Scale (MIDAS), while general function and treatment satisfaction were assessed using custom questionnaires. Electronic medical records and the results of imaging upon diagnosis were reviewed retrospectively. RESULTS: The stented group reported significantly better outcomes in physical well-being (median 4.0 vs. 1.0, p < 0.001), task completion (4.0 vs. 1.0, p < 0.001), work/school persistence (5.0 vs. 1.0, p < 0.001), and mental well-being (4.0 vs. 1.0, p < 0.001). Additionally, the stented group had a lower proportion of patients with severe MIDAS (MIDAS > 4, 24.3% vs. 47.9%, p = 0.017). Logistic regression suggested venous stenting as a protective factor against severe MIDAS scores (OR = 0.174, p = 0.004). CONCLUSION: Cerebral venous stenting in patients with IIH is associated with lower disability and higher patient satisfaction from medical treatment compared to those treated with medications only. These findings suggest that venous sinus stenting may be a valuable treatment option for selected IIH patients. However, larger prospective studies are needed to further validate our results.

• Publication type
• Journal Article MeSH

The molecular mechanisms linking obstructive sleep apnea syndrome (OSA) to obesity and the development of metabolic diseases are still poorly understood. The role of hypoxia (a characteristic feature of OSA) in excessive fat accumulation has been proposed. The present study investigated the possible effects of hypoxia (4% oxygen) on de novo lipogenesis by tracking the major carbon sources in differentiating 3T3-L1 adipocytes. Gas-permeable cultuware was employed to cultivate 3T3-L1 adipocytes in hypoxia (4%) for 7 or 14 days of differentiation. We investigated the contribution of glutamine, glucose or acetate using 13C or 14C labelled carbons to the newly synthesized lipid pool, changes in intracellular lipid content after inhibiting citrate- or acetate-dependent pathways and gene expression of involved key enzymes. The results demonstrate that, in differentiating adipocytes, hypoxia decreased the synthesis of lipids from glucose (44.1 ± 8.8 to 27.5 ± 3.0 pmol/mg of protein, p < 0.01) and partially decreased the contribution of glutamine metabolized through the reverse tricarboxylic acid cycle (4.6% ± 0.2-4.2% ± 0.1%, p < 0.01). Conversely, the contribution of acetate, a citrate- and mitochondria-independent source of carbons, increased upon hypoxia (356.5 ± 71.4 to 649.8 ± 117.5 pmol/mg of protein, p < 0.01). Further, inhibiting the citrate- or acetate-dependent pathways decreased the intracellular lipid content by 58% and 73%, respectively (p < 0.01) showing the importance of de novo lipogenesis in hypoxia-exposed adipocytes. Altogether, hypoxia modified the utilization of carbon sources, leading to alterations in de novo lipogenesis in differentiating adipocytes and increased intracellular lipid content.

• MeSH
• Acetates * metabolism   pharmacology   MeSH
• Cell Differentiation * drug effects   MeSH
• 3T3-L1 Cells * MeSH
• Citric Acid Cycle MeSH
• Glucose * metabolism   MeSH
• Glutamine * metabolism   MeSH
• Cell Hypoxia MeSH
• Lipids biosynthesis   MeSH
• Lipogenesis * drug effects   MeSH
• Lipid Metabolism drug effects   MeSH
• Mice MeSH
• Adipocytes * metabolism   drug effects   MeSH
• Animals MeSH
• Check Tag
• Mice MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH

PURPOSE: The IMMUNOSARC trial combined an antiangiogenic agent (sunitinib) with a PD1 inhibitor (nivolumab) in advanced sarcomas. Here, we present the first correlative studies of the soft-tissue sarcoma cohort enrolled in this trial. EXPERIMENTAL DESIGN: Formalin-fixed paraffin-embedded and peripheral blood samples were collected at baseline and week 13. Formalin-fixed paraffin-embedded samples were used for transcriptomics and multiplex immunofluorescence, whereas peripheral blood samples were used for multiplexed immunoassays. Flow cytometry and Luminex assays were performed to validate translational findings in tumor-isolated cells and peripheral blood mononuclear cells derived from patients. RESULTS: The density of intratumoral CD8+ T cells, measured by multiplexed immunophenotyping, was significantly increased after treatment. This augment was accompanied by the dynamic significant increase in the gene expressions of CD86, CHI3L1, CXCL10, CXCL9, LAG3, and VCAM1 and the decrease in the expression levels of NR4A1. In peripheral blood, 12 proteins were significantly modulated by treatment at week 13. A score integrating the dynamic expression of the 7 genes and the 12 soluble factors separated 2 groups with distinct progression-free survival (PFS): 4.1 months [95% confidence interval, 3.5-not reached (NR)] versus 17 months (95% confidence interval, 12.0-NR), P = 0.014. This molecular score was predictive of PFS when applied to the normalized data determined in the baseline samples. CONCLUSIONS: Treatment with sunitinib and nivolumab inflamed the sarcoma microenvironment, increasing CD8+ T-cell density and the expression of several genes/proteins with relevance in the response to PD1 inhibitors. A molecular signature identified two groups of patients with distinct PFS for the combination of antiangiogenics plus PD1 inhibitor therapy.

• MeSH
• Programmed Cell Death 1 Receptor antagonists & inhibitors   MeSH
• CD8-Positive T-Lymphocytes immunology   drug effects   metabolism   MeSH
• Adult MeSH
• Angiogenesis Inhibitors therapeutic use   administration & dosage   MeSH
• Immune Checkpoint Inhibitors therapeutic use   pharmacology   MeSH
• Middle Aged MeSH
• Humans MeSH
• Biomarkers, Tumor MeSH
• Tumor Microenvironment drug effects   immunology   MeSH
• Nivolumab therapeutic use   administration & dosage   MeSH
• Prognosis MeSH
• Antineoplastic Combined Chemotherapy Protocols therapeutic use   MeSH
• Sarcoma * drug therapy   pathology   genetics   MeSH
• Aged MeSH
• Lymphocytes, Tumor-Infiltrating immunology   metabolism   drug effects   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH

This study evaluated the effects of a neuromuscular training (NMT) warm-up program on injury incidence, neuromuscular function, and program adherence, maintenance and acceptance in adolescent basketball players. A total of 275 players from 20 Slovenian teams (15 ± 1.7 years of age), were randomized into an intervention group (IG, n=129) and a control group (CG, n=146). Over three months, the IG incorporated NMT into their warm-ups, while the CG followed their usual practice. Measurements of body anthropometry, muscle contractile properties, and balance were taken before and after the intervention. Also, the injury incidence, training adherence and maintenance were reported. Both groups showed improved balance, with no significant difference between them. However, IG demonstrated reduced delay times in specific muscles, indicating improved neuromuscular function. Injury prevalence proportion (%) during the whole study period was higher in the control group compared to intervention (IG: 10.9% vs. CG: 23.3%), and incidence rate. Moreover, the incidence rate ratio for sustaining an injury was 2.6 on average (ranging from 0.88 to 7.07 for tendon and muscle injuries, respectively), indicating significantly lower injury risk in IG than CG. These findings highlight the effectiveness of NMT warm-ups in reducing injury risk and enhancing neuromuscular function, emphasizing the value of structured injury prevention strategies in youth sports..

• MeSH
• Anthropometry MeSH
• Basketball * injuries   physiology   MeSH
• Incidence MeSH
• Physical Conditioning, Human methods   MeSH
• Muscle, Skeletal injuries   physiology   MeSH
• Humans MeSH
• Adolescent MeSH
• Tendon Injuries prevention & control   epidemiology   MeSH
• Postural Balance physiology   MeSH
• Athletic Injuries * prevention & control   epidemiology   MeSH
• Muscle Contraction physiology   MeSH
• Muscle Strength physiology   MeSH
• Warm-Up Exercise * MeSH
• Check Tag
• Humans MeSH
• Adolescent MeSH
• Male MeSH
• Publication type
• Journal Article MeSH
• Randomized Controlled Trial MeSH
• Geographicals
• Slovenia MeSH

RATIONALE: Cabergoline (CAB) is an ergot derivative typically prescribed for the treatment of hyperprolactinemia. It suppresses the release of prolactin through agonist actions on dopamine (DA) D2 receptors; however, it possesses binding affinity for other DA and 5-HT receptors. Side effects that exacerbate valvular heart disease can occur with high doses. OBJECTIVE: The present study examined the acute, subchronic, and chronic dose-response effects of CAB and a derivative dimethylcabergoline (DMC) which acts as an antagonist instead of agonist at 5-HT 2B receptors, on appetitive and consummatory sexual behaviors of male rats. METHODS: CAB (0, 0.03, 0.15, or 0.3 mg/kg/ml) was administered daily to sexually experienced male rats (N = 10/dose) by oral gavage for a total of 68 days. Sexual behavior was tested every 4 days during this period for a total of 16 trials. On the 17th trial, rats were administered their dose of CAB, and 4 h after were overdosed with sodium pentobarbital, perfused intracardially, and their brains processed for Fos immunohistochemistry. DMC (0, 0.03, 0.15, 0.3 mg/kg/ml) was administered daily to sexually experienced male rats (N = 10/dose) by oral gavage for a total of 36 days. Sexual behavior was tested every 4 days for a total of 9 trials. RESULTS: CAB increased anticipatory level changes, intromissions, and ejaculations significantly across all timepoints, with the medium and high doses being most potent. The medium and high doses also increased Fos protein significantly within the medial preoptic area, whereas in the nucleus accumbens shell, the low and medium doses decreased Fos protein but the high dose increased it significantly from control. Similar to CAB, the medium and high doses of DMC increased the number of ejaculations significantly. Rats in all drug dose groups appeared healthy for the duration of the experiments. CONCLUSIONS: Both CAB and DMC facilitate ejaculations, and CAB further facilitates measures of anticipatory sexual motivation and intromissions. These data suggest that both could be used as treatments for sexual arousal disorders and ejaculation/orgasm disorders with little or no untoward side effects at low doses.

• MeSH
• Cabergoline pharmacology   MeSH
• Copulation * MeSH
• Rats MeSH
• Motivation MeSH
• Brain MeSH
• Gonadal Steroid Hormones MeSH
• Receptors, Dopamine D2 MeSH
• Sexual Behavior, Animal * MeSH
• Animals MeSH
• Check Tag
• Rats MeSH
• Male MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH

Andjelkovic, Marija, Peter Paal, Susi Kriemler, Kaste Mateikaite-Pipiriene, Alison Rosier, Beth Beidleman, Mia Derstine, Jacqueline Pichler Hefti, David Hillebrandt, Lenka Horakova, Dominique Jean, and Linda E. Keyes. Nutrition in women at high altitude: a scoping review-UIAA Medical Commission recommendations. High Alt Med Biol. 25:9-15, 2024. Background: Nutritional concerns such as food composition, energy intake, and nutrient absorption are essential for performance at high altitude and may differ between men and women. We performed a scoping review to summarize what is currently known on nutrition for women during short-term, high-altitude, physically active sojourns. Methods: The UIAA Medical Commission convened an international team to review women's health issues at high altitude and to publish updated recommendations. Pertinent literature from PubMed and Cochrane was identified by keyword search combinations (including nutrition, metabolism, energy composition, micronutrients) with additional publications found by hand search. Results: We found 7,165 articles, of which 13 original articles assessed nutritional aspects in physically active women on short-term high-altitude sojourns, with other articles found by hand search. We summarize the main findings. Conclusions: Data on women's nutrition at altitude are very limited. Reduction in energy intake plus increased energy expenditure at high altitude can lead to unbalanced nutrition, negatively influencing high-altitude adaptation and physical performance. Therefore, adequate dietary and fluid intake is essential to maintaining energy balance and hydration at high altitude in women as in men. Iron supplementation should be considered for women with iron depletion before travel.

• MeSH
• Diet * MeSH
• Humans MeSH
• Altitude * MeSH
• Iron MeSH
• Check Tag
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Review MeSH

• MeSH
• Bariatric Surgery * MeSH
• Humans MeSH
• Metabolic Diseases * surgery   MeSH
• Obesity, Morbid * surgery   MeSH
• Obesity surgery   MeSH
• Anniversaries and Special Events MeSH
• Check Tag
• Humans MeSH
• Publication type
• Letter MeSH

Publikace informuje o průběhu a prostředí porodu a o potřebách rodící ženy. Určeno odborné veřejnosti.; Shrnutí životních potřeb rodící ženy vycházejících především z pocitu bezpečí a lásky.

• MeSH
• Mothers psychology   MeSH
• Parturition MeSH
• Pregnant People psychology   MeSH
• Maternal Health MeSH
• Healthy Lifestyle MeSH

• Conspectus
• Gynekologie. Porodnictví
• NML Fields
• gynekologie a porodnictví
• NML Publication type
• informační publikace