NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master regulator of redox homeostasis regulating a variety of genes for antioxidant and detoxification enzymes. NRF2 was, therefore, initially thought to protect the liver from oxidative stress. Recent studies, however, have revealed that mutations in NRF2 cause aberrant accumulation of NRF2 in the nucleus and exert the upregulation of NRF2 target genes. Moreover, among all molecular changes in hepatocellular carcinoma (HCC), NRF2 activation has been revealed as a more prominent pathway contributing to the progression of precancerous lesions to malignancy. Nevertheless, how its activation leads to poor prognosis in HCC patients remains unclear. In this review, we provide an overview of how aberrant activation of NRF2 triggers HCC development. We also summarize the emerging roles of other NRF family members in liver cancer development.

• MeSH
• aktivace transkripce * MeSH
• analýza přežití MeSH
• faktor 2 související s NF-E2 genetika   metabolismus   MeSH
• genové regulační sítě MeSH
• hepatocelulární karcinom diagnóza   genetika   mortalita   patologie   MeSH
• karcinogeneze genetika   metabolismus   patologie   MeSH
• KEAP-1 genetika   metabolismus   MeSH
• lidé MeSH
• mutace MeSH
• nádorové buněčné linie MeSH
• nádory jater diagnóza   genetika   mortalita   patologie   MeSH
• oxidace-redukce MeSH
• oxidační stres MeSH
• prognóza MeSH
• regulace genové exprese u nádorů * MeSH
• signální transdukce MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH