Begusová, M*
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Published survival data of V79 cells irradiated by 0.5-5.0 MeV (7-40 keV/microm) protons have been analyzed with a detailed radiobiological model to estimate the per-track yields of lethal lesions. Their correlations with distribution patterns of deposited energy, radical concentrations and with the yields of specific classes of DNA damage have been studied. The observed correlations indicate a potential interpretation of DNA damage lethal for the cell and the initial physical and chemical processes leading to such damage.
A large-scale, double-stream gas puff target has been illuminated by sub-kJ, near-infrared (NIR) focused laser pulses at the PALS facility (Prague Asterix Laser System) to produce high-energy pulses of soft X rays from hot, dense plasma. The double-puff arrangement ensures high gas density and conversion efficiency from NIR to X rays approaching that typical for solid targets. In addition, its major advantage over solid targets is that it is free of debris and has substantially suppressed charged-particle emission. The X-ray emission characteristics of the source were determined for a range of gases that included krypton, xenon, N(2), CO and N(2)-CO. A demonstrated application of the xenon-based source is a single-shot damage induction to plasmid DNA. The yields of single-strand breaks (SSBs) and double-strand breaks (DSBs) were determined as a function of energy fluence adjusted by varying distance of sample from the source and thickness of aluminum filters.
- MeSH
- analýza selhání vybavení MeSH
- dávka záření MeSH
- design vybavení MeSH
- lasery MeSH
- nanotechnologie metody přístrojové vybavení MeSH
- odběr biologického vzorku metody přístrojové vybavení MeSH
- plazmidy chemie účinky léků MeSH
- poškození DNA účinky záření MeSH
- radiobiologie metody přístrojové vybavení MeSH
- rentgenové záření MeSH
- výzkum přístrojové vybavení MeSH
- výzkumný projekt MeSH
- Publikační typ
- hodnotící studie MeSH
