Crew size
Dotaz
Zobrazit nápovědu
PURPOSE: Obesity is associated with increased bioavailability of estrogen, hyperinsulinemia, and chronic inflammation, all of which may promote tumor growth. Given DNA repair and oxidative stress pathways may work together with these mechanisms to influence carcinogenesis, we hypothesized that genetic variation in these pathways may modify the obesity-postmenopausal breast cancer (BC) association. METHODS: Resources from a population-based case-control study (990 cases and 970 controls) were used to construct logistic regression models. Body mass index (BMI, weight [kilogram]/height [square meter]) was assessed 1 year before reference date. We characterized interactions between BMI and 29 genetic polymorphisms in oxidative stress and DNA repair pathways. RESULTS: Age-adjusted odds ratios (95% confidence intervals) for postmenopausal BC were 1.24 (1.00-1.52) and 1.35 (1.09-1.71) for 25 ≥ BMI < 30 and BMI ≥ 30 kg/m(2), respectively. We observed multiplicative interactions (P ≤ .05) for eight gene polymorphisms in DNA repair and oxidative stress pathways. For example, among MPO variant allele carriers, obesity was associated with a twofold increased risk of postmenopausal BC (2.13 [1.35-3.36]); however, in wild-type homozygotes, the relationship was less pronounced (1.33 [0.93-1.89]). Our findings were no longer significant after Bonferroni correction. CONCLUSIONS: Obesity may be particularly deleterious for postmenopausal BC development in the presence of biologically plausible DNA repair or oxidative stress genotypes.
- MeSH
- dospělí MeSH
- genetické asociační studie MeSH
- index tělesné hmotnosti MeSH
- jednonukleotidový polymorfismus genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- nádory prsu genetika MeSH
- oprava DNA genetika MeSH
- oxidační stres genetika MeSH
- polymorfismus genetický genetika MeSH
- postmenopauza MeSH
- rizikové faktory MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- velikost těla genetika MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Research Support, N.I.H., Extramural MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
... Age and Size at Maturity 99 -- Derek A. Roff -- 9. Offspring Size and Number 113 -- Frank J. ... ... Sex and Gender 154 -- Turk Rhen David Crews -- 13. ...
1st ed. xii, 424 s.
... AND FEMALE AIRCREW -- Assessment of Anthropometric Accommodation in Aircraft Cockpits and Pilot Body Size ... ... Andrews -- SESSION VI: CREW RESOURCE MANAGEMENT, DESIGN ISSUES AND TRAINING -- ANALYSIS TECHNIQUES -- ...
AGARD conference proceedings ; 588
1 svazek : ilustrace ; 30 cm
- MeSH
- letecké a kosmické lékařství MeSH
- letectví MeSH
- řízení kvality MeSH
- vyučování MeSH
- výzkum MeSH
- vzdělávání odborné MeSH
- Publikační typ
- kongresy MeSH
- sborníky MeSH
- zprávy MeSH
- Konspekt
- Lékařské vědy. Lékařství
- NLK Obory
- hyperbarická a letecká medicína
BACKGROUND: Non-technical skills (NTS) are important for the proper functioning of emergency medical ambulance crews but have hardly been researched in the conditions of clinical pre-hospital care. The primary objective of this study, therefore, is to describe the use of NTS in practice. The secondary objective is to compare if the performance of NTS varies according to the type of case. METHODS: In this multicentric observational study the modified Team Emergency Assessment Measure (TEAM) score was used to assess the performed NTS of two or more crews on site. The evaluation consisted of leadership, teamwork and task management, rated by a field supervisor. The study observations took place in real clinical pre-hospital emergency medical cases when two or more crews were dispatched between October 2019 and August 2020. The sample size was determined by researchers prior to the study to at least 100 evaluated events per each of the three participating emergency medical services. The results are presented as median and interquartile range. The internal reliability, consistency and validity of test items and results were evaluated. The Kruskal-Wallis test and the post hoc Mann-Whitney U test with Bonferroni correction were used for multiple comparisons of three groups. RESULTS: A total of 359 events were evaluated. Surprisingly, the median value for all eight items was as high as 3.0 with a similar interquartile range of 1.0. There were no differences observed by case type (CPR vs. TRAUMA vs. MEDICAL) except from item 1. A post hoc analysis revealed that this difference is in favour of a higher rated performance of non-technical skills in CPR. CONCLUSIONS: The overall result of the performance of non-technical skills can be regarded as very good and can serve for further evaluations. The crews achieved better parameters of NTS in leadership in resuscitation situations in comparison with general medical events. TRIAL REGISTRATION: The study is registered at Clinical Trials under the ID: NCT04503369 .
- MeSH
- klinické kompetence * MeSH
- lidé MeSH
- nemocnice * MeSH
- prospektivní studie MeSH
- reprodukovatelnost výsledků MeSH
- týmová péče o pacienty MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- pozorovací studie MeSH
- Geografické názvy
- Česká republika MeSH