Úvod. Výsledná kvalita jizevnaté tkáně hraje důležitou roli v návratu pacientů do normálního života a společnosti. Používání umělých kožních náhrad v klinické praxi zlepšuje funkční i kosmetické výsledky nejen u popálených pacientů. Materiál a metody. Kolagen-elastinová dermální náhrada Matriderm® umožňuje okamžitou aplikaci spolu s kožním štěpem. Autoři prezentují na souboru 10 pacientů první zkušenosti s použitím dermální náhrady Matridem® v léčbě kožních ztrát různé etiologie. Výsledky. Průměrná doba hojení v soboru byla 19,6 dne, hojení probíhalo bez závažných infekčních komplikací s dobrým kosmetickým a funkčním výsledkem. Závěr. Matriderm® představuje alternativní variantu dosud nejčastěji používané dermální náhrady Integra® v léčbě akutních kožních ztrát různé etiologie i v rekonstrukční chirurgii.

Introduction. The quality of resulting scar tissue plays an important role in patients' return to normal life and full functioning in society. The use of artificial skin substitutes in clinical practice improves functional and cosmetic outcomes. This is true for any patient, and not only those suffering from burns. Material and methods. The collagen elastin dermal substitute Matriderm® allows for immediate application of a dermal substitute together with a skin graft. The authors present a group of 10 patients representing their first experience in utilizing Matriderm® as a dermal substitute in the treatment of skin losses due to various etiologies. Results. The average healing time in the group was 19.6 days. Healing took place without serious infectious complications and with good functional results. Conclusion. Matriderm® can be utilized as an alternative to the most commonly used dermal substitute so far, Integra® , in the treatment of acute skin loss due to various etiologies and in reconstructive surgery.

• Klíčová slova
• Matriderm,
• MeSH
• dítě MeSH
• elastin aplikace a dávkování   MeSH
• klinická studie jako téma MeSH
• kolagen aplikace a dávkování   MeSH
• lidé MeSH
• transplantace kůže metody   MeSH
• umělá kůže * MeSH
• Check Tag
• dítě MeSH
• lidé MeSH

Working memory is a cognitive process that involves short-term active maintenance, flexible updating, and processing of goal- or task-relevant information. All frequency bands are involved in working memory. The activities of the theta and gamma frequency bands in the frontoparietal network are highly involved in working memory processes; theta oscillations play a role in the temporal organization of working memory items, and gamma oscillations influence the maintenance of information in working memory. Transcranial alternating current stimulation (tACS) results in frequency-specific modulation of endogenous oscillations and has shown promising results in cognitive neuroscience. The electrophysiological and behavioral changes induced by the modulation of endogenous gamma frequency in the prefrontal cortex using tACS have not been extensively studied in the context of working memory. Therefore, we aimed to investigate the effects of frontal gamma-tACS on working memory outcomes. We hypothesized that a 10-min gamma tACS administered over the frontal cortex would significantly improve working memory outcomes. Young healthy participants performed Luck-Vogel cognitive behavioral tasks with simultaneous pre- and post-intervention EEG recording (Sham versus 40 Hz tACS). Data from forty-one participants: sham (15 participants) and tACS (26 participants), were used for the statistical and behavioral analysis. The relative changes in behavioral outcomes and EEG due to the intervention were analyzed. The results show that tACS caused an increase in the power spectral density in the high beta and low gamma EEG bands and a decrease in left-right coherence. On the other hand, tACS had no significant effect on success rates and response times. Conclusion: 10 min of frontal 40 Hz tACS was not sufficient to produce detectable behavioral effects on working memory, whereas electrophysiological changes were evident. The limitations of the current stimulation protocol and future directions are discussed in detail in the following sections.

• Publikační typ
• časopisecké články MeSH

Excessive connective tissue accumulation, a hallmark of hypertrophic scaring, results in progressive deterioration of the structure and function of organs. It can also be seen during tumor growth and other fibroproliferative disorders. These processes result from a wide spectrum of cross-talks between mesenchymal, epithelial and inflammatory/immune cells that have not yet been fully understood. In the present review, we aimed to describe the molecular features of fibroblasts and their interactions with immune and epithelial cells and extracellular matrix. We also compared different types of fibroblasts and their roles in skin repair and regeneration following burn injury. In summary, here we briefly review molecular changes underlying hypertrophic scarring following burns throughout all basic wound healing stages, i.e. during inflammation, proliferation and maturation.

• MeSH
• epitelové buňky metabolismus   patologie   MeSH
• extracelulární matrix metabolismus   patologie   MeSH
• fibroblasty metabolismus   patologie   MeSH
• hojení ran genetika   MeSH
• jizva hypertrofická genetika   imunologie   patologie   MeSH
• lidé MeSH
• popálení genetika   patologie   MeSH
• proliferace buněk genetika   MeSH
• zánět genetika   patologie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH