The Auxin Binding Protein 1 (ABP1) is one of the most studied proteins in plants. Since decades ago, it has been the prime receptor candidate for the plant hormone auxin with a plethora of described functions in auxin signaling and development. The developmental importance of ABP1 has recently been questioned by identification of Arabidopsis thaliana abp1 knock-out alleles that show no obvious phenotypes under normal growth conditions. In this study, we examined the contradiction between the normal growth and development of the abp1 knock-outs and the strong morphological defects observed in three different ethanol-inducible abp1 knock-down mutants ( abp1-AS, SS12K, SS12S). By analyzing segregating populations of abp1 knock-out vs. abp1 knock-down crosses we show that the strong morphological defects that were believed to be the result of conditional down-regulation of ABP1 can be reproduced also in the absence of the functional ABP1 protein. This data suggests that the phenotypes in  abp1 knock-down lines are due to the off-target effects and asks for further reflections on the biological function of ABP1 or alternative explanations for the missing phenotypic defects in the abp1 loss-of-function alleles.

• Publikační typ
• časopisecké články MeSH

• MeSH
• dolní končetina MeSH
• krvácení komplikace   terapie   MeSH
• senioři MeSH
• skleroterapie metody   MeSH
• sklerotizující roztoky aplikace a dávkování   škodlivé účinky   terapeutické užití   MeSH
• varixy chirurgie   komplikace   MeSH
• žilní insuficience terapie   MeSH
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• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• srovnávací studie MeSH

• MeSH
• komplikace těhotenství MeSH
• skleroterapie MeSH
• varixy MeSH
• žilní insuficience MeSH

• MeSH
• dítě MeSH
• imunita genetika   MeSH
• infekce respiračními syncytiálními viry imunologie   terapie   virologie   MeSH
• lidé MeSH
• respirační syncytiální viry imunologie   MeSH
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• dítě MeSH
• lidé MeSH