The existence of pattern recognition receptors (PRRs) on immune cells was discussed in 1989 by Charles Janeway, Jr., who proposed a general concept of the ability of PRRs to recognize and bind conserved molecular structures of microorganisms known as pathogen-associated molecular patterns (PAMPs). Upon PAMP engagement, PRRs trigger intracellular signaling cascades resulting in the expression of various proinflammatory molecules. These recognition molecules represent an important and efficient innate immunity tool of all organisms. As invertebrates lack the instruments of the adaptive immune system, based on "true" lymphocytes and functional antibodies, the importance of PRRs are even more fundamental. In the present review, the structure, specificity, and expression profiles of PRRs characterized in annelids are discussed, and their role in innate defense is suggested.

• MeSH
• kroužkovci imunologie   MeSH
• membránové glykoproteiny chemie   genetika   metabolismus   MeSH
• PAMP struktury imunologie   metabolismus   MeSH
• přirozená imunita * MeSH
• proteiny akutní fáze chemie   genetika   metabolismus   MeSH
• receptory rozpoznávající vzory chemie   genetika   metabolismus   MeSH
• regulace genové exprese MeSH
• signální transdukce imunologie   MeSH
• tkáňová distribuce MeSH
• toll-like receptory chemie   genetika   metabolismus   MeSH
• transportní proteiny chemie   genetika   metabolismus   MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH