The existence of pattern recognition receptors (PRRs) on immune cells was discussed in 1989 by Charles Janeway, Jr., who proposed a general concept of the ability of PRRs to recognize and bind conserved molecular structures of microorganisms known as pathogen-associated molecular patterns (PAMPs). Upon PAMP engagement, PRRs trigger intracellular signaling cascades resulting in the expression of various proinflammatory molecules. These recognition molecules represent an important and efficient innate immunity tool of all organisms. As invertebrates lack the instruments of the adaptive immune system, based on "true" lymphocytes and functional antibodies, the importance of PRRs are even more fundamental. In the present review, the structure, specificity, and expression profiles of PRRs characterized in annelids are discussed, and their role in innate defense is suggested.
- MeSH
- kroužkovci imunologie MeSH
- membránové glykoproteiny chemie genetika metabolismus MeSH
- PAMP struktury imunologie metabolismus MeSH
- přirozená imunita * MeSH
- proteiny akutní fáze chemie genetika metabolismus MeSH
- receptory rozpoznávající vzory chemie genetika metabolismus MeSH
- regulace genové exprese MeSH
- signální transdukce imunologie MeSH
- tkáňová distribuce MeSH
- toll-like receptory chemie genetika metabolismus MeSH
- transportní proteiny chemie genetika metabolismus MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- MeSH
- imunitní systém imunologie MeSH
- kroužkovci anatomie a histologie imunologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- kongresy MeSH
