The head posture is considered as one of the signifi cant indicators of the patients with CNS disorders. Th e exact head posture measurement would be great contribution for objectifi cation and quantifi cation of these disorders. Th ere has been used many diff erent methods to measure the head posture. Th e proposed method is based on the contact-less measurement of the head posture. A camera system is used to obtain video sequences of the subject. Each image is analyzed and signifi cant points are detected. Th e correspondences between these points are considered.

• MeSH
• audiovizuální záznam využití   MeSH
• financování organizované MeSH
• fotografování metody   MeSH
• hlava - pohyby MeSH
• lidé MeSH
• nemoci centrálního nervového systému diagnóza   MeSH
• počítačové zpracování obrazu metody   přístrojové vybavení   využití   MeSH
• postura těla MeSH
• radiografie metody   využití   MeSH
• zobrazování trojrozměrné metody   využití   MeSH
• Check Tag
• lidé MeSH

Parkinson's disease is a degenerative disorder of the central nervous system that oft en impairs the suff erer's motor skills and causes specifi c disturbances of hand motor function. We measure the 3-dimensional hand motion trajectory of the patients, when they perform a natural manual transport task (moving an object from one place to another). Th e patients perform the task repeatedly. For the evaluation and classifi cation of the movement, it is important to select proper parameters. For this reason, we created the set of testing movements. We focused on the variance of the periodic movement. We created and tested algorithm for the computation of the variance.

• MeSH
• algoritmy MeSH
• audiovizuální záznam metody   přístrojové vybavení   využití   MeSH
• experimenty na lidech MeSH
• financování organizované MeSH
• lidé MeSH
• Parkinsonova nemoc diagnóza   patofyziologie   MeSH
• počítačové zpracování obrazu metody   využití   MeSH
• pohybové poruchy diagnóza   patofyziologie   MeSH
• ruka patofyziologie   MeSH
• studie pohybu a času MeSH
• zobrazování trojrozměrné metody   přístrojové vybavení   využití   MeSH
• Check Tag
• lidé MeSH

Tetraphenylporphyrin conjugates with one (PB1) and four (PB4) cobalt(III) bis(1,2-dicarbollide) substituents were synthesized and the physicochemical and photophysical properties as well as inhibition of HIV-1 protease were described. In methanol, both PB1 and PB4 were monomeric producing the triplet states and singlet oxygen after excitation. The triplet states of PB4 were quickly protonated. Porphyrins exhibited a small decrease of the quantum yields of the singlet oxygen formation (17% for PB4 and 13% for PB1) as compared with 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin. On the contrary, no singlet oxygen was detected in aqueous solutions because of strong aggregation. Light scattering and atomic force microscopy (AFM) measurements documented that the behavior of aggregates in aqueous solutions is fairly complex and depends on pH, concentration, and aging. The aggregation started from spherical particles in neutral solutions. In acidic solutions, extended aggregation occurred because of slow protonation of the porphyrin pyrrole nitrogen atoms. Both PB1 and PB4 are new representatives of nonpeptide HIV-1 protease inhibitors. Their activity increased with the increasing number of the cobalt(III) bis(1,2-dicarbollide) substituents and was characterized with the IC50 values of 290+/-44 nM for PB1 and 77+/-13 nM for PB4.

• MeSH
• financování organizované MeSH
• HIV-proteasa metabolismus   MeSH
• inhibiční koncentrace 50 MeSH
• inhibitory HIV-proteasy farmakologie   chemie   MeSH
• kyslík chemie   MeSH
• mikroskopie atomárních sil MeSH
• molekulární modely MeSH
• molekulární struktura MeSH
• organokovové sloučeniny chemie   MeSH
• porfyriny farmakologie   chemie   MeSH
• sloučeniny boru chemie   MeSH
• substrátová specifita MeSH