Q95396041
Dotaz
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Thermal analysis is a valuable method in pharmaceutical research. A wide range of thermal methods are used in drug development like thermogravimetry (TG), diffe¬rential thermal analysis (DTA), differential scanning calori¬metry (DSC) and other sensitive and specific methods. The present review deals with application of these me¬thods in characterization of drugs and excipients, such as their polymorph stability, glass transition temperature, purity analysis and compatibility of drugs.
- Klíčová slova
- termické metody, farmaceutický vývoj, DSC, skelný přechod, polymorfismus, kompatibilita,
- MeSH
- chemické techniky analytické MeSH
- diferenciální skenovací kalorimetrie metody MeSH
- farmaceutická technologie MeSH
- fyzikální chemie MeSH
- léčivé přípravky MeSH
- příprava léků MeSH
- termografie metody MeSH
- termogravimetrie metody MeSH
- výzkum MeSH
- Publikační typ
- práce podpořená grantem MeSH
Pharmaceutical excipients may occur in polymorphs and other solid forms and as active pharmaceutical ingredients. Excipients, polymorphs or the forms are not specified in the patient information leaflets on the dosage forms. Polymorphs of lactose, mannitol and sorbitol, various forms of cellulose and its derivatives, starch forms and poly(N-vinylpyrrolidone) are discussed in detail here. Identification of polymorphs and other solid forms can be carried out by X-ray powder diffraction as well as by IR, Raman and solid-state NMR spectroscopies.
