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Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021-2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study

... Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel ...

Simoes, Margarida Pires
Author Simoes, Margarida Pires ORCID Centre for Infectious Disease Control, Dutch National Public Health Institute, Bilthoven, The Netherlands European Program for Public Health Microbiology Training, European Centre for Disease Prevention and Control, Stockholm, Sweden
Hodcroft, Emma B
Author Hodcroft, Emma B ORCID Geneva Center of Emerging Viral Diseases, Geneva University Hospital and University of Geneva, Geneva, Switzerland Swiss Institute of Bioinformatics, Lausanne, Switzerland Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland
Simmonds, Peter
Author Simmonds, Peter ORCID Nuffield Department for Medicine, University of Oxford, Oxford, United Kingdom
Albert, Jan
Author Albert, Jan ORCID Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden Department of Microbiology, Tumor, and Cell Biology, Karolinska Institutet, Stockholm, Sweden
Alidjinou, Enagnon K
Author Alidjinou, Enagnon K Laboratoire de Virologie ULR, Univ Lille, Centre Hospitalier Universitaire de Lille, Lille, France
Ambert-Balay, Katia
Author Ambert-Balay, Katia ORCID National Reference Centre for Gastroenteritis Viruses, Laboratory of Virology-Serology, University Hospital of Dijon Bourgogne, Dijon, France
Andrés, Cristina
Author Andrés, Cristina ORCID Respiratory Viruses Unit, Microbiology Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Institut of Research, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain Microbiology Department, Hospital Unviersitario La Paz, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain
Antón, Andrés
Author Antón, Andrés ORCID Respiratory Viruses Unit, Microbiology Department, Vall d'Hebron Hospital Universitari, Vall d'Hebron Institut of Research, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain Microbiology Department, Hospital Unviersitario La Paz, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain
Auvray, Christelle
Author Auvray, Christelle ORCID National Reference Centre for Gastroenteritis Viruses, Laboratory of Virology-Serology, University Hospital of Dijon Bourgogne, Dijon, France
Bailly, Jean-Luc
Author Bailly, Jean-Luc ORCID Labaratoire Microorganismes: Génome Environnement-Epidemiology and Physiopathology of Enterovirus Diseases LMGE-EPIE Team, Université Clermont Auvergne, CNRS, Clermont-Ferrand, France

The Journal of infectious diseases. 2024 ; 230 (4) : e917-e928. [pub] 20241016

J Infect Dis
ISSN 1537-6613
Medvik
Source

Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 infections and its clinical impact during the fall-winter season of 2021-2022. From 19 European countries, 58 institutes reported 10 481 (6.8%) EV-positive samples of which 1004 (9.6%) were identified as EV-D68 (including 852 respiratory samples). Clinical data were reported for 969 cases; 78.9% of infections were reported in children (0-5 years); and 37.9% of cases were hospitalized. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases including 6 diagnosed with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of 2 novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale European EV-D68 upsurge with severe clinical impact and the emergence of B3-derived lineages.