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28 záznamů v BMČ Filtry

Článek

Psilocybin-assisted neurofeedback for the improvement of executive functions: a randomized semi-naturalistic-lab feasibility study

Enriquez-Geppert, S
Autor Enriquez-Geppert, S ORCID Department of Clinical and Developmental Neuropsychology, University of Groningen , Groningen, Netherlands Department of Biomedical Sciences of Cells & Systems, University Medical Center Groningen , Groningen, Netherlands
Krc, J
Autor Krc, J Department of Clinical and Developmental Neuropsychology, University of Groningen , Groningen, Netherlands Department of Psychiatry, Faculty of Medicine, Masaryk University and University Hospital Brno , Brno, Czech Republic
O'Higgins, F J
Autor O'Higgins, F J Trinity College Institute of Neuroscience, School of Medicine, Trinity College Dublin, The University of Dublin , Dublin, Ireland Academic Unit of Neurology, Trinity Biomedical Sciences Institute, School of Medicine, Trinity College Dublin, The University of Dublin , Dublin, Ireland
Lietz, M
Autor Lietz, M Department of Clinical and Developmental Neuropsychology, University of Groningen , Groningen, Netherlands Department of Medicine, Faculty of Science and Medicine, University of Fribourg , Fribourg, Switzerland

Philosophical transactions - Royal Society of London. Biological sciences. 2024 ; 379 (1915) : 20230095. [pub] 20241021

Philos Trans R Soc Lond B Biol Sci
ISSN 1471-2970
Medvik
Zdroj

Executive function deficits, common in psychiatric disorders, hinder daily activities and may be linked to diminished neural plasticity, affecting treatment and training responsiveness. In this pioneering study, we evaluated the feasibility and preliminary efficacy of psilocybin-assisted frontal-midline theta neurofeedback (NF), a neuromodulation technique leveraging neuroplasticity, to improve executive functions (EFs). Thirty-seven eligible participants were randomized into an experimental group (n = 18) and a passive control group (n = 19). The experimental group underwent three microdose sessions and then three psilocybin-assisted NF sessions, without requiring psychological support, demonstrating the approach's feasibility. NF learning showed a statistical trend for increases in frontal-midline theta from session to session with a large effect size and non-significant but medium effect size dynamical changes within sessions. Placebo effects were consistent across groups, with no tasks-based EF improvements, but significant self-reported gains in daily EFs-working memory, shifting, monitoring and inhibition-showing medium and high effect sizes. The experimental group's significant gains in their key training goals underscored the approach's external relevance. A thorough study with regular sessions and an active control group is crucial to evaluate EFs improvement and their specificity in future. Psilocybin-enhanced NF could offer significant, lasting benefits across diagnoses, improving daily functioning. This article is part of the theme issue 'Neurofeedback: new territories and neurocognitive mechanisms of endogenous neuromodulation'.

Kapitola

Kritický pohled na využití EEG biofeedbacku v neuropsychologii

Ondřej, Lukáš, 1980-
Autor Autorita Acquired Brain Injury Services, SweetTree HCS, Londýn, Velká Británie

Klinická neuropsychologie v praxi. 2023 ; () : 927-934.

ISBN 978-80-246-5197-2
Medvik
Zdroj

Článek

Effect of neurofeedback therapy on neurological post-COVID-19 complications (A pilot study)

PLoS One. 2022 ; 17 (7) : e0271350. [pub] 20220727

ISSN 1932-6203
Medvik
Zdroj

OBJECTIVE: Anxiety, fatigue and depression are common neurological manifestations after COVID-19. So far, post-COVID complications were treated by rehabilitation, oxygen therapy and immunotherapy. Effects of neurofeedback on post-COVID complications and their potential interrelatedness have not been studied yet. In this pilot study, we investigated the effectiveness of neurofeedback (Othmer method) for treatment of fatigue, anxiety, and depression after COVID-19. METHODS: 10 participants met inclusion criteria for having positive anamnesis of at least one of the following complications following COVID-19: fatigue, anxiety, and depression which were measured by questionnaires. ANOVA was used for calculating differences in questionnaire score before and after neurofeedback. Pearson's correlation coefficient was used to calculate correlations between anxiety, depression and fatigue. RESULTS: After five neurofeedback sessions, there came to significant reduction of severity of post-COVID anxiety and depression persisting for at least one month. Effect of neurofeedback on fatigue was insignificant. Severity of anxiety, fatigue and depression as well as reductions in depression and fatigue were positively correlated with each other. CONCLUSION: These findings showed effectiveness neurofeedback for reducing anxiety and depression after COVID-19 and for studying correlations between neurological complications after COVID-19. However, since our pilot clinical trial was open-label, it is hard to differentiate between neurofeedback-specific and unspecific effects on our participants. Future randomized controlled trials with more robust sample are necessary to investigate feasibility of neurofeedback for post-COVID neurological complications. The study has identification number trial ID ISRCTN49037874 in ISRCTN register of clinical trials (Retrospectively registered).

Článek

Je dítě pouze zlobivé, nebo má ADHD?

Svět praktické medicíny. 2021 ; 2021 (4) : 84-89.

ISSN 2694-8516
Medvik
Zdroj

Web zdroj

Neurobiologické mechanismy funkčních neurologických poruch [Neurobiological mechanisms of functional neurological symptoms]

Bareš, Martin, 1968-
Autor Autorita ORCID
Baláž, Marek
Autor Autorita
Masarykova univerzita. Lékařská fakulta
Autor Autorita
Fakultní nemocnice u svaté Anny (Brno, Česko)
Autor Autorita

2020

Závěrečná zpráva o řešení grantu Agentury pro zdravotnický výzkum MZ ČR

Nestr.

Although functional neurological symptoms (FNS) are closely connected to the origins of neurology and psychiatry, they remain poorly understood. As a consequence, the diagnosis of the FNS is made by exclusion of organic cause and therefore does not provide any specific cues for the subsequent treatment. Recent research in cognitive neuroscience suggests that the FNS can be described as problems with abnormal awareness towards body together with abnormal prior beliefs about symptoms. Importantly, involvement of limbic areas in symptom production has long been highlighted but not confirmed. The aim of this project is to research a neurobiological mechanism of the FNS and to develop a treatment approach for the disorder based on the identified pathogenic mechanism as well as on identified behavioral and psychophysiological markers of the FNS. Specifically, virtual reality assessment is tested as a potential therapeutic intervention for the functional neurological disorders.

Funkční neurologické symptomy jsou spjaty s počátky neurologie i psychiatrie, přesto doposud neexistuje spolehlivý model umožňující jejich porozumění. Také diagnostika funkčních neurologických poruch vyloučením organické příčiny neposkytuje žádná vodítka pro léčbu. Neurovědní výzkumy z poslední doby přinášejí stále více dokladů o tom, že funkční neurologické symptomy je možné popsat jako poruchy na tělo-zaměřené pozornosti společně s abnormálním očekáváním ohledně symptomů. Rovněž podíl limbických oblastí na vzniku symptomů je dlouho zastávanou avšak doposud neověřenou hypotézou. Předmětem projektu je výzkum neurobiologických mechanismů funkčních neurologických symptomů a návrh terapeutického postupu pro léčbu funkčních neurologických poruch, který by byl postaven na znalosti patofyziologického mechanismu onemocnění a na jejích behaviorálních a fyziologických projevech. V rámci tohoto cíle bude ověřeno, zda je imerze ve virtuální realitě vhodným terapeutickým nástrojem pro léčbu funkčních neurologických poruch.

MeSH
emoční regulace MeSH
konverzní poruchy patofyziologie terapie MeSH
lidé MeSH
motorické poruchy MeSH
neurofeedback MeSH
neurozobrazování metody MeSH
psychogenní neepileptické záchvaty MeSH
terapie pomocí virtuální reality MeSH
Check Tag
lidé MeSH

Konspekt
Patologie. Klinická medicína
NLK Obory
neurologie
psychiatrie
NLK Publikační typ
závěrečné zprávy o řešení grantu AZV MZ ČR

Článek

fMRI neurofeedback in emotion regulation: A literature review

Neuroimage. 2019 ; 193 (-) : 75-92. [pub] 20190309

ISSN 1095-9572
Medvik
Zdroj

OBJECTIVES: Emotion regulation is one of the most prevalent objectives for real-time fMRI neurofeedback (rt-fMRI-NF) studies. The existing studies differ in a number of methodological parameters. This study provides a literature review of the main parameters and results of studies using rt-fMRI-NF for emotion regulation enhancement. METHOD: A search of the Web of Science database up through November 8, 2018, identified 144 articles written in English, 89 of which were excluded as irrelevant for this study. The remaining 51 original studies and four secondary analyses of previously published original studies were included in the literature review. The selection of target brain areas, target populations, emotion regulation protocols, NF presentation, control group types, and emotion regulation instructions were examined in relation to achieved brain regulation and changes in cognitive or clinical outcomes. Study results were evaluated in terms of their statistical robustness. RESULTS: The results show that healthy people are able to regulate their brain activity in the presence of rt-fMRI-NF from various brain regions related to emotion regulation, including the amygdala, anterior insula, and anterior cingulate cortex. The regulation of brain activity using rt-fMRI-NF from prefrontal-limbic connectivity or from individually navigated brain areas is feasible as well. Most studies that used a control group show that rt-fMRI-NF actually induces some effects on brain regulation, cognitive variables, and clinical variables. Generally, the success of ROI regulation during NF training is related to the combination of target brain region, the type of emotion regulation task, and the population undergoing the training. In terms of patient groups, the strongest support for the beneficial effects of rt-fMRI-NF has been shown in increased positive emotion experiencing in patients with depression and in decreased anxiety in patients with anxiety disorders. Symptom reduction following NF training has been also reported in patients with PTSD, BPD, and schizophrenia, but direct comparisons with control groups in these studies makes it impossible to evaluate the added value of NF. Studies often do not report all the relevant analyses for evaluating NF success and many studies lack statistical robustness. CONCLUSIONS: Overall, rt-fMRI-NF seems a promising tool for emotion regulation enhancement with the potential to induce long-term symptom reduction in patients with various mental disorders. Preplanning of statistical analyses, careful interpretations of the results, and evaluations of the NF effect on symptom reduction in patient groups is recommended.