- MeSH
- COVID-19 komplikace MeSH
- dítě * MeSH
- domácí násilí * prevence a kontrola psychologie MeSH
- hodnocení rizik metody MeSH
- internetové poradenství metody MeSH
- lidé MeSH
- posílání textových zpráv MeSH
- rizikové faktory MeSH
- sociální péče o dítě psychologie MeSH
- Check Tag
- dítě * MeSH
- lidé MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- COVID-19 * epidemiologie psychologie MeSH
- distanční studium metody MeSH
- domácí násilí * psychologie MeSH
- internetové poradenství metody MeSH
- krizová intervence metody statistika a číselné údaje MeSH
- kvalitativní výzkum MeSH
- lidé MeSH
- psychosociální intervence metody MeSH
- sociální izolace psychologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
We review the current understanding of formation and development of the coronary microvasculature which supplies oxygen and nutrients to the heart myocardium and removes waste. We emphasize the close relationship, mutual development, and communication between microvasculature endothelial cells and surrounding cardiomyocytes. The first part of the review is focused on formation of microvasculature during embryonic development. We summarize knowledge about establishing the heart microvasculature density based on diffusion distance. Then signaling mechanisms which are involved in forming the microvasculature are discussed. This includes details of cardiomyocyte-endothelial cell interactions involving hypoxia, VEGF, NOTCH, angiopoietin, PDGF, and other signaling factors. The microvasculature is understudied due to difficulties in its visualization. Therefore, currently available imaging methods to delineate the coronary microvasculature in development and in adults are discussed. The second part of the review is dedicated to the importance of the coronary vasculature in disease. Coronary microvasculature pathologies are present in many congenital heart diseases (CHD), especially in pulmonary atresia, and worsen outcomes. In CHDs, where the development of the myocardium is impaired, microvasculature is also affected. In adult patients coronary microvascular disease is one of the main causes of sudden cardiac death, especially in women. Coronary microvasculature pathologies affect myocardial ischemia and vice versa; myocardial pathologies such as cardiomyopathies are closely connected with coronary microvasculature dysfunction. Microvasculature inflammation also worsens the outcomes of COVID-19 disease. Our review stresses the importance of coronary microvasculature and provides an overview of its formation and signaling mechanisms and the importance of coronary vasculature pathologies in CHDs and adult diseases. This article is categorized under: Cardiovascular Diseases > Stem Cells and Development Congenital Diseases > Molecular and Cellular Physiology Cardiovascular Diseases > Molecular and Cellular Physiology.
- MeSH
- COVID-19 MeSH
- dospělí MeSH
- endoteliální buňky MeSH
- kardiomyocyty * metabolismus MeSH
- kardiovaskulární nemoci * metabolismus MeSH
- lidé MeSH
- mikrocévy diagnostické zobrazování MeSH
- myokard * metabolismus MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
INTRODUCTION: The COVID-19 pandemic has been challenging time for medical care, especially in the field of infectious diseases (ID), but it has also provided an opportunity to introduce new solutions in HIV management. Here, we investigated the changes in HIV service provision across Central and Eastern European (CEE) countries before and after the COVID-19 outbreak. METHODS: The Euroguidelines in Central and Eastern Europe Network Group consists of experts in the field of ID from 24 countries within the CEE region. Between 11 September and 29 September 2021, the group produced an on-line survey, consisting of 32 questions on models of care among HIV clinics before and after the SARS-CoV-2 outbreak. RESULTS: Twenty-three HIV centers from 19 countries (79.2% of all countries invited) participated in the survey. In 69.5% of the countries, there were more than four HIV centers, in three countries there were four centers (21%), and in four countries there was only one HIV center in each country. HIV care was based in ID hospitals plus out-patient clinics (52%), was centralized in big cities (52%), and was publicly financed (96%). Integrated services were available in 21 clinics (91%) with access to specialists other than ID, including psychologists in 71.5% of the centers, psychiatrists in 43%, gynecologists in 47.5%, dermatologists in 52.5%, and social workers in 62% of all clinics. Patient-centered care was provided in 17 centers (74%), allowing consultations and tests to be planned for the same day. Telehealth tools were used in 11 centers (47%) before the COVID-19 pandemic outbreak, and in 18 (78%) after (p = 0.36), but were represented mostly by consultations over the telephone or via e-mail. After the COVID-19 outbreak, telehealth was introduced as a new medical tool in nine centers (39%). In five centers (28%), no new services or tools were introduced. CONCLUSIONS: As a consequence of the COVID-19 pandemic, tools such as telehealth have become popularized in CEE countries, challenging the traditional approach to HIV care. These implications need to be further evaluated in order to ascertain the best adaptations, especially for HIV medicine.
- MeSH
- COVID-19 * epidemiologie terapie MeSH
- HIV infekce * epidemiologie terapie MeSH
- lidé MeSH
- pandemie MeSH
- SARS-CoV-2 MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa MeSH
- východní Evropa MeSH
1. vydání 173, 5 stran : barevné ilustrace, mapy ; 30 cm
Výzkumná zpráva ze studie, která se zaměřila na politiku zvýhodňování nezaměstnaných a znevýhodněných osob v době pandemie COVID-19 v Česku. Určeno odborné veřejnosti.
- MeSH
- COVID-19 MeSH
- dějiny 21. století MeSH
- ekonomika MeSH
- nezaměstnanost MeSH
- socioekonomické faktory MeSH
- veřejná politika MeSH
- zaměstnanost MeSH
- Check Tag
- dějiny 21. století MeSH
- Publikační typ
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
- Konspekt
- Práce
- NLK Obory
- sociologie
- ekonomie, ekonomika, ekonomika zdravotnictví
- politologie, politika, zdravotní politika
- NLK Publikační typ
- výzkumné zprávy
- brožury
- kolektivní monografie
- studie
- MeSH
- bariatrie * metody MeSH
- bupropion aplikace a dávkování terapeutické užití MeSH
- COVID-19 MeSH
- dítě MeSH
- fixní kombinace léků MeSH
- lidé MeSH
- liraglutid aplikace a dávkování terapeutické užití MeSH
- naltrexon aplikace a dávkování terapeutické užití MeSH
- obezita farmakoterapie komplikace prevence a kontrola MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- MeSH
- COVID-19 * epidemiologie psychologie MeSH
- duševní zdraví statistika a číselné údaje MeSH
- hodnotící studie jako téma MeSH
- internetové poradenství metody statistika a číselné údaje MeSH
- lidé MeSH
- poskytování zdravotní péče metody statistika a číselné údaje MeSH
- průzkumy a dotazníky statistika a číselné údaje MeSH
- psychosociální intervence * metody statistika a číselné údaje MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- COVID-19 psychologie MeSH
- duševní poruchy psychologie terapie MeSH
- internetové poradenství * etika metody MeSH
- klinická studie jako téma MeSH
- kognitivně behaviorální terapie metody MeSH
- lidé MeSH
- psychoterapie * metody MeSH
- telemedicína metody MeSH
- vztahy mezi zdravotnickým pracovníkem a pacientem etika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- amfotericin B farmakologie terapeutické užití MeSH
- antifungální látky farmakologie terapeutické užití MeSH
- COVID-19 * komplikace terapie MeSH
- dospělí MeSH
- lidé MeSH
- septický šok MeSH
- umělé dýchání škodlivé účinky MeSH
- ventilátorová pneumonie etiologie terapie MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
Running across the globe for nearly 2 years, the Covid-19 pandemic keeps demonstrating its strength. Despite a lot of understanding, uncertainty regarding the efficiency of interventions still persists. We developed an age-structured epidemic model parameterized with epidemiological and sociological data for the first Covid-19 wave in the Czech Republic and found that (1) starting the spring 2020 lockdown 4 days earlier might prevent half of the confirmed cases by the end of lockdown period, (2) personal protective measures such as face masks appear more effective than just a realized reduction in social contacts, (3) the strategy of sheltering just the elderly is not at all effective, and (4) leaving schools open is a risky strategy. Despite vaccination programs, evidence-based choice and timing of non-pharmaceutical interventions remains an effective weapon against the Covid-19 pandemic.
- MeSH
- biologické modely MeSH
- COVID-19 * epidemiologie prevence a kontrola MeSH
- kontrola infekčních nemocí MeSH
- lidé MeSH
- masky * MeSH
- matematické pojmy MeSH
- pandemie prevence a kontrola MeSH
- SARS-CoV-2 MeSH
- senioři MeSH
- školy MeSH
- Check Tag
- lidé MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
