- MeSH
- Candida albicans patogenita MeSH
- fyziologie výživy MeSH
- kandidóza * etiologie patofyziologie patologie terapie MeSH
- léčivé rostliny MeSH
- lidé MeSH
- mykózy * etiologie patofyziologie patologie terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- populární práce MeSH
- MeSH
- bakteriální infekce * diagnóza patologie terapie MeSH
- imunosupresivní léčba škodlivé účinky MeSH
- lidé MeSH
- mykózy diagnóza patologie terapie MeSH
- pooperační komplikace MeSH
- rizikové faktory MeSH
- transplantace orgánů * MeSH
- virové nemoci diagnóza patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Bradymyces oncorhynchi is a poorly known melanised fungal species that has been isolated only from a hyperaemic focus near the enlarged spleen of a rainbow trout. Although the pathogenicity of this species to fish is suspected, it has not been fully confirmed. Four laboratory experiments were conducted to test the effect of the fungus on the health of rainbow trout fingerlings. Mycelia were cultivated under different conditions to increase inoculum variability and to test the impact of the conditions on the pathogenicity. The inoculum was subsequently administered by the intraperitoneal route. The clinical manifestations, gross pathological lesions and histopathological changes were identical in all experimental groups, i.e. lethargy, inappetence, anorexia, weight reduction, pale gills, full-thickness ulceration of the abdominal wall, muscle atrophy, haemorrhagic or pale liver, fat-altered pyloric region with haemorrhages, enlarged spleen, haemorrhagic ascites, systemic granulomatous lesions with the presence of melanised hyphae (phaeohyphomycosis), multifocal granulomatous hepatitis, perivascular lymphocytic infiltration, vacuolation of hepatocytes and vacuolation of the kidney tubule epithelium. No statistically significant differences were found in the survival of the fish with respect to experimental settings. The survival period ranged between 3 and 135 days.
- MeSH
- aktinomykóza MeSH
- antifungální látky terapeutické užití MeSH
- blastomykóza MeSH
- chromoblastomykóza diagnóza farmakoterapie mikrobiologie patologie MeSH
- diferenciální diagnóza MeSH
- kokcidioidomykóza MeSH
- kultivační techniky MeSH
- lidé MeSH
- lobomykóza MeSH
- mukormykóza MeSH
- mycetom diagnóza farmakoterapie mikrobiologie patologie MeSH
- mykózy * epidemiologie farmakoterapie mikrobiologie patologie MeSH
- nokardióza MeSH
- oportunní infekce diagnóza etiologie farmakoterapie mikrobiologie MeSH
- rinosporidióza MeSH
- sporotrichóza diagnóza farmakoterapie mikrobiologie patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Colletotrichum species are known as important pathogens of plants with an impact on crop production. Some of these species are also known as a cause of rare ophthalmic infections in humans. A case of keratitis caused by Colletotrichum dematium after corneal trauma in a 56-year-old woman is presented. Infection was diagnosed based on positive microscopy and culture. The fungal isolate was identified by morphological characteristics and DNA sequencing of the ITS rDNA region, β-tubulin (tub2) and glyceraldehyde-3-phosphate dehydrogenase (gapdh) genes. The patient responded well to topical therapy with amphotericin B combined with intravenous amphotericin B but improvement was associated with the corneal collagen cross-linking. The review of the literature revealed another 13 cases of C. dematium keratitis, all but one patient having at least one keratitis risk factor in their history. Almost all patients (n = 12) were treated with topical polyene antibiotics (natamycin or amphotericin B), improvement and cure were achieved in eight of them.
- MeSH
- amfotericin B aplikace a dávkování MeSH
- antifungální látky aplikace a dávkování MeSH
- aplikace lokální MeSH
- Colletotrichum klasifikace genetika izolace a purifikace MeSH
- diagnostické techniky molekulární MeSH
- dospělí MeSH
- glyceraldehyd-3-fosfátdehydrogenasa (fosforylační) genetika MeSH
- keratitida diagnóza mikrobiologie patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mezerníky ribozomální DNA genetika MeSH
- mikrobiologické techniky MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mykózy diagnóza mikrobiologie patologie MeSH
- poranění oka komplikace MeSH
- sekvenční analýza DNA MeSH
- tubulin genetika MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- systematický přehled MeSH
Spontaneous invasive and chronic disseminated mycosis affected Hemigrammus pulcher kept in a public aquarium, and infection was manifested by inappetence, exophthalmia, erratic swimming, eroded scales, anaemia of the gills and abdominal distension. Internally, there was a grossly swollen swim bladder with a thickened wall filled with a dark mass. The body cavities contained a clear, light amber fluid and a swollen intestine which was full of a watery fluid containing small gas bubbles. Histopathology revealed a granulomatous inflammatory response with fungal hyphae in the lumen and wall of the swim bladder, hepatopancreas, spleen and kidneys with signs of nephrohydrosis. Exophiala pisciphila and Phaeophleospora hymenocallidicola were isolated from the swim bladder, abdominal cavity and gastrointestinal tract. The exogenous source of infection was probably the ample wooden decoration and plants inside the aquarium. Koch's postulates were fulfilled by re-isolation of both fungal species from fish artificially infected under laboratory conditions. As P. hymenocallidicola is less capable of defence against phagocytosis, E. pisciphila probably played a major role. Severe clinical manifestations with 100% mortality developed in two fish species infected by E. pisciphila. A significant increase in the plasma levels of amino acids was observed as a result of the activation of proteolysis.
- MeSH
- Ascomycota patogenita fyziologie MeSH
- Characidae * MeSH
- Exophiala patogenita fyziologie MeSH
- mykózy mikrobiologie patologie patofyziologie veterinární MeSH
- nemoci ryb mikrobiologie patologie patofyziologie MeSH
- vzdušné vaky mikrobiologie patologie patofyziologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Transplantace plic (LTx) je zásadním léčebným postupem pro vybranou skupinu pacientů v terminálním stadiu řady plicních onemocnění. S pokroky transplantační chirurgie je dnes pro přežití pacientů limitující nikoliv perioperační období, ale spíše fáze měsíců až let po LTx. Potransplantační období je pro pacienty po LTx velmi složité kvůli speciálnímu léčebnému režimu a možnosti výskytu mnoha komplikací, ať už časných nebo pozdních, či akutních nebo chronických. Tyto komplikace můžeme dělit na rejekce, infekce, nádory, neinfekční plicní komplikace a mimoplicní komplikace. Jde o velmi široké spektrum různorodých stavů a k jejich řešení je nutná mimo spolupráci pacientů hlavně týmová kooperace specialistů mnoha medicínských oborů.
Lung transplantation (LTx) is an essential treatment for a selected group of patients in the terminal stage of a number of lung diseases. With advances in transplant surgery, patients are currently limiting for perioperative periods, but rather for months to years after LTx. The post-transplant period is very complicated for LTx patients due to a special treatment regimen and the possibility of many complications, whether Ccirly or late or acute or chronic. These complications can be divided into rejections, infections, tumors, non-infectious pulmonary complications and extrapulmonary complications. This is a very wide range of diverse states and to cope with them, it is necessary, apart from patient co-operation, to team together with specialists in many fields of medicine.
- MeSH
- aspergilóza diagnóza farmakoterapie patologie MeSH
- bakteriální infekce diagnóza farmakoterapie patologie MeSH
- Cytomegalovirus patogenita MeSH
- infekce klasifikace patologie terapie MeSH
- lidé MeSH
- mykózy diagnóza farmakoterapie patologie MeSH
- nádory MeSH
- nemoci dýchací soustavy diagnóza patologie terapie MeSH
- parazitární nemoci MeSH
- pneumocystová pneumonie diagnóza farmakoterapie patologie MeSH
- rejekce štěpu * diagnóza farmakoterapie klasifikace MeSH
- rizikové faktory MeSH
- transplantace plic * MeSH
- Check Tag
- lidé MeSH
In underground hibernacula temperate northern hemisphere bats are exposed to Pseudogymnoascus destructans, the fungal agent of white-nose syndrome. While pathological and epidemiological data suggest that Palearctic bats tolerate this infection, we lack knowledge about bat health under pathogen pressure. Here we report blood profiles, along with body mass index (BMI), infection intensity and hibernation temperature, in greater mouse-eared bats (Myotis myotis). We sampled three European hibernacula that differ in geomorphology and microclimatic conditions. Skin lesion counts differed between contralateral wings of a bat, suggesting variable exposure to the fungus. Analysis of blood parameters suggests a threshold of ca. 300 skin lesions on both wings, combined with poor hibernation conditions, may distinguish healthy bats from those with homeostatic disruption. Physiological effects manifested as mild metabolic acidosis, decreased glucose and peripheral blood eosinophilia which were strongly locality-dependent. Hibernating bats displaying blood homeostasis disruption had 2 °C lower body surface temperatures. A shallow BMI loss slope with increasing pathogen load suggested a high degree of infection tolerance. European greater mouse-eared bats generally survive P. destructans invasion, despite some health deterioration at higher infection intensities (dependant on hibernation conditions). Conservation measures should minimise additional stressors to conserve constrained body reserves of bats during hibernation.
- MeSH
- Ascomycota fyziologie MeSH
- Chiroptera krev mikrobiologie fyziologie MeSH
- hibernace * MeSH
- index tělesné hmotnosti MeSH
- interakce hostitele a patogenu * MeSH
- kožní nemoci krev mikrobiologie patologie veterinární MeSH
- mykózy krev mikrobiologie patologie veterinární MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Patients with critical thermal trauma belong to one of the most high-risk groups for development of infectious complications. Fungal infections are not among frequent complications during therapy of patients with thermal trauma, yet their incidence dramatically aggravates the prognosis for patients with this disorder. In the case report, we present the case of a young man with a critical burn, where Westerdykella dispersa was isolated. Identification of the pathogen was provided with a combination of cultivation and molecular biological confirmation. In this case, the distinction between infection and colonization was very complicated. Histopathological examination for definitive diagnosis of infection was not performed because the material from unburned soft tissue sampling could further compromise the function of the hand. Repeated cultivation and molecular identification W. dispersa before and after the necrectomy is indicative of infection rather than colonization. It is the second documented case of positive cultivation with this pathogen in humans and the first such case in a non-neutropenic host.
- MeSH
- antifungální látky farmakologie terapeutické užití MeSH
- Ascomycota účinky léků izolace a purifikace fyziologie MeSH
- DNA fungální genetika MeSH
- lidé MeSH
- mezerníky ribozomální DNA genetika MeSH
- mikrobiální testy citlivosti MeSH
- mladý dospělý MeSH
- mykózy farmakoterapie etiologie mikrobiologie patologie MeSH
- popálení komplikace MeSH
- RNA ribozomální 5.8S genetika MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
- Geografické názvy
- Česká republika MeSH
Species of Scedosporium and Lomentospora are considered as emerging opportunists, affecting immunosuppressed and otherwise debilitated patients, although classically they are known from causing trauma-associated infections in healthy individuals. Clinical manifestations range from local infection to pulmonary colonization and severe invasive disease, in which mortality rates may be over 80%. These unacceptably high rates are due to the clinical status of patients, diagnostic difficulties, and to intrinsic antifungal resistance of these fungi. In consequence, several consortia have been founded to increase research efforts on these orphan fungi. The current review presents recent findings and summarizes the most relevant points, including the Scedosporium/Lomentospora taxonomy, environmental distribution, epidemiology, pathology, virulence factors, immunology, diagnostic methods, and therapeutic strategies.
- MeSH
- antifungální látky farmakologie terapeutické užití MeSH
- Ascomycota klasifikace účinky léků genetika fyziologie MeSH
- chirurgie operační MeSH
- ekologie MeSH
- faktory virulence MeSH
- hostitel s imunodeficiencí MeSH
- interakce hostitele a patogenu imunologie MeSH
- kombinovaná terapie MeSH
- lidé MeSH
- mnohočetná fungální léková rezistence genetika MeSH
- molekulární typizace MeSH
- mykózy diagnóza mikrobiologie patologie terapie MeSH
- oportunní infekce diagnóza mikrobiologie patologie terapie MeSH
- Scedosporium klasifikace účinky léků genetika fyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
