AIM: This study aimed to analyze the influence of the hospital admitting department on adherence to the Guidelines of European Society of Cardiology for management of acute coronary syndromes in patients after out-of-hospital cardiac arrest (OHCA) of coronary etiology. METHODS: We studied retrospective-prospective register of 102 consecutive patients with OHCA as a manifestation of acute coronary syndrome (ACS). Patients were admitted to the coronary care unit (CCU) 52, general intensive care unit (GICU) 21, or GICU after initial Cath lab treatment (CAG-GICU) 29. This study compared the differences in the management of ACS in patients with OHCA of coronary etiology based on the admitting department in a tertiary care institution. RESULTS: Twelve of the 21 (57.1%) patients admitted to the GICU were evaluated as having ACS on-site where they experienced OHCA. In the CCU group, 50 out of 52 (96.2%) and 28 of 29 (100%) patients in the CAG-GICU group (P<0.001). Coronary angiography was performed in 10 of 21 patients (48%) admitted to the GICU. It was performed in 49 out of 52 (94%) CCU patients and, in the CAG-GICU group, 28 out of 29 patients. The mean time to CAG differed significantly across groups (that is, GICU 200.7 min., CCU 71.2 min., and CAG-GICU 7.5 min. (P<0.001)). Aspirin was used in 48% of GICU, 96% of CCU, and 79% of CAG-GICU patients (P<0.001), while in the pre-hospital phase, aspirin was used in 9.5% of GICU, 71.2% of CCU, and 50% of CAG-GICU patients (P<0.001). P2Y12 inhibitor prescriptions were lower in patients admitted to the GICU (33% vs. 89% CCU and 57% CAG-GICU, P<0.001). The department's choice significantly affected the time to initiation of antithrombotics, which was the longest in the GICU. CONCLUSION: The choice of admission department for patients with OHCA caused by ACS was found to affect the extent to which the recommended treatments were used. An examination of OHCA patients by a cardiologist upon admission to the hospital increased the likelihood of an early diagnosis of ACS as the cause of OHCA.
- MeSH
- akutní koronární syndrom * komplikace terapie MeSH
- Aspirin terapeutické užití MeSH
- koronární angiografie škodlivé účinky MeSH
- koronární angioplastika * škodlivé účinky MeSH
- lidé MeSH
- přijímací oddělení nemocnice * MeSH
- retrospektivní studie MeSH
- zástava srdce mimo nemocnici * etiologie terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
AIMS: Refractory out-of-hospital cardiac arrest (r-OHCA) in patients with pulmonary embolism (PE) is associated with poor outcomes. The role of extracorporeal cardiopulmonary resuscitation (ECPR) in this patient group is uncertain. This study aims to analyse clinical course, outcomes, and the effect of an invasive procedure, including ECPR, in a randomized population. METHODS AND RESULTS: A post hoc analysis of a randomized controlled trial (Prague OHCA study) was conducted to evaluate the effect of ECPR vs. a standard approach in r-OHCA. A subgroup of patients with PE-related r-OHCA was identified, and procedural and outcome characteristics, including favourable neurological survival, organ donation, and complications, were compared to patients without PE. Pulmonary embolism was identified as a cause of r-OHCA in 24 of 256 (9.4%) enrolled patients. Patients with PE were more likely to be women [12/24 (50%) vs. 32/232 (13.8%); P < 0.001] and presented more frequently with an initial non-shockable rhythm [23/24 (95.8%) vs. 77/232 (33.2%); P < 0.001], as well as more severe acidosis at admission [median pH (interquartile range); 6.83 (6.75-6.88) vs. 6.98 (6.82-7.14); P < 0.001]. Their favourable 180-day neurological survival was significantly lower [2/24 (8.3%) vs. 66/232 (28.4%); P = 0.049], but the proportion of accepted organ donors was higher (16.7 vs. 4.7%, P = 0.04). CONCLUSION: Refractory out-of-hospital cardiac arrest due to PE has a different presentation and inferior outcomes compared to other causes but may represent an important source of organ donations. The ECPR method did not improve patient outcomes.
- MeSH
- kardiopulmonální resuscitace * metody MeSH
- lidé MeSH
- mimotělní membránová oxygenace * metody MeSH
- plicní embolie * etiologie komplikace MeSH
- retrospektivní studie MeSH
- zástava srdce mimo nemocnici * etiologie terapie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
Sudden cardiac death (SCD) is a major medical, economic and social problem. The estimated annual number of SCDs is approximately 4 million cases worldwide. Approximately 50% of SCDs are unexpected first manifestations of cardiac disease. The survival rate after out-of-hospital cardiac arrest is low even in countries with the most advanced health care systems. It all emphasizes the importance of prevention, in which implantable cardioverter-defibrillators play a dominant role. However, our ability to recognize high-risk patients remains insufficient. Moreover, a declining rate of shockable rhythm as the initial recording has been reported in the last decades. Despite numerous SCD studies and undisputed progress, there are still many unanswered questions.
- MeSH
- defibrilátory implantabilní * škodlivé účinky MeSH
- dilatační kardiomyopatie komplikace MeSH
- dospělí MeSH
- fatální výsledek MeSH
- infarkt myokardu etiologie komplikace MeSH
- kardiopulmonální resuscitace metody MeSH
- lidé MeSH
- péče o pacienty v kritickém stavu MeSH
- selhání zařízení MeSH
- srdeční zástava * etiologie terapie MeSH
- transplantace srdce škodlivé účinky MeSH
- urgentní zdravotnické služby MeSH
- zástava srdce mimo nemocnici etiologie terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
AIMS: The ESCAPE-NET project ("European Sudden Cardiac Arrest network- towards Prevention, Education and New Effective Treatments") aims to study: (1) risk factors and mechanisms for the occurrence of sudden cardiac arrest (SCA) in the population, and (2) risk factors and treatment strategies for survival after SCA on a European scale. METHODS: This is an Horizon2020 funded program of the European Union, performed by a European public-private consortium of 16 partners across 10 EU countries. There are 11 deep-phenotyped SCA cohorts for the study of risk factors and treatment strategies for survival after SCA, and 5 deep-phenotyped observational prospective population cohorts for the study of risk factors for occurrence of SCA. Personalized risk scores for predicting SCA onset and for predicting survival after SCA will be derived and validated. RESULTS: The 11 clinical studies with SCA cases comprise 85,790 SCA cases; the 5 observational prospective population cohorts include 53,060 subjects. A total of 15,000 SCA samples will be genotyped for common and rare variants at the Helmholtz Zentrum München (Germany) using the Illumina Global Screening Array which contains > 770,000 SNPs, and after imputation, a database of an estimated > 9 million variants will be available for genome wide association studies. Standardization of risk factors definition and outcomes is ongoing. An Executive Committee has been created along with a Collaboration Policy document. CONCLUSION: ESCAPE-NET will complement ongoing efforts on SCA outside Europe and within Europe including the EuReCa project.
- MeSH
- databáze faktografické MeSH
- hodnocení rizik MeSH
- kohortové studie MeSH
- komorbidita MeSH
- lidé MeSH
- náhlá srdeční smrt epidemiologie MeSH
- rizikové faktory MeSH
- surveillance populace metody MeSH
- urgentní zdravotnické služby statistika a číselné údaje MeSH
- zástava srdce mimo nemocnici etiologie mortalita MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa MeSH
Úvod: Mimonemocniční srdeční zástava (OHCA) patří v rozvinutých zemích mezi nejčastější příčiny úmrtí dospělé populace. Centralizace poresuscitační péče může vést ke zlepšení prognózy pacientů. Společné stanovisko České kardiologické společnosti a odborných společností urgentní medicíny doporučuje zřídit centra pro diagnostiku a léčbu pacientů po OHCA mimo jiné i s využitím již existující infrastruktury sítě kardiocenter. V Libereckém kraji tento systém péče funguje od roku 2016. Cílem naší práce je prezentovat roční zkušenosti po změně organizace péče v porovnání s předchozími lety. Metody: Do registru byli konsekutivně zařazeni všichni pacienti, kteří byli léčeni v Kardiocentru Krajské nemocnice Liberec (KNL) po OHCA od 1. dubna 2016 do 1. dubna 2017. Byla sledována mortalita a neurologický stav do 30. dne od přijetí. Získaná data byla porovnána s registrem pacientů hospitalizovaných na tomto oddělení po OHCA a úspěšné resuscitaci od 1. ledna 2013 do 31. listopadu 2015. Výsledky: Po změně organizace péče došlo k nárůstu primárně transportovaných pacientů o 39,5 % (0,81 vs. 1,13 pacienta týdně). Došlo k statisticky významnému navýšení poměru pacientů s nedefibrilovatelným iniciálním rytmem (25,2 vs. 42,6 %, p = 0,013). Navzdory tomu se poměr pacientů s kardiovaskulární příčinou srdeční zástavy významně nezměnil (71,4 vs. 77,0 %). Taktéž nedošlo ke snížení podílu pacientů s akutním koronárním syndromem (47,6 vs. 44,3 %). Nedošlo k signifikantní změně počtu pacientů podstupujících selektivní koronarografii (63,9 vs. 54,1 %) a perkutánní koronární intervenci (35,4 vs. 36,1 %). Došlo k vzestupu 30denní mortality, který nebyl statisticky významný (36,7 vs. 49,2, p = 0,096). Většina přeživších pacientů (75,4 vs. 71,0 %) byla v dobrém neurologickém stavu. Závěr: Centralizace péče o pacienty po srdeční zástavě s využitím zavedené infrastruktury kardiocentra je v našem regionu proveditelná. Došlo k významnému navýšení jak primárně transportovaných pacientů, tak i celkového počtu ročně přijatých pacientů. Podíl pacientů s jinou než kardiovaskulární příčinou srdeční zástavy se nezměnil. Nedošlo k signifikantnímu zhoršení mortality či neurologického cílového ukazatele.
Introduction: Out-of-hospital cardiac arrest (OHCA) is one of the most common causes of death in the adult population in developed countries. Centralization of post-resuscitation care may improve the patients' prognosis. Expert statement of the Czech Society of Cardiology recommends the establishment of cardiac arrest centers using the infrastructure of existing tertiary cardiac centers. The introduction of this system in the region of Liberec started in April 2016. The aim of our work is to present the one-year results compared to the results from previous years. Methods: All patients treated in the Department of Cardiology of Regional Hospital Liberec after OHCA from 1st April 2016 to 1st April 2017 were enrolled consecutively. Neurological status and mortality were evaluated for the time period of 30 days from the day of admission. The data were compared to the registry of patients hospitalized in the same department after OHCA and successful resuscitation from 1st January 2013 to 31st November 2015. Results: After the establishment of the Cardiac Arrest Centre, an increase of primarily transported patients of 39.5% (0.81 vs. 1.13 patient per week) was observed. There was a statistically significant increase in the proportion of patients with non-shockable rhythm (25.2 vs. 42.6%, p = 0.013). Despite this, the proportion of patients with cardiovascular etiology of cardiac arrest did not change (71.4 vs. 77.0%). There was also no reduction in the proportion of patients with acute coronary syndrome (47.6 vs. 44.3%). There was no statistically significant change of proportion of patients undergoing selective coronarography (63.9 vs. 54.1%) and percutaneous coronary intervention (35.4 vs. 36.1%). There was an increase in 30-day mortality, which was not statistically significant (36.7 vs. 49.2%, p = 0.096). Most of the surviving patients (75.4 vs. 71.0%) were in a good neurological condition. Conclusion: Centralization of post cardiac arrest care using previously established infrastructure is feasible in our region. Furthermore, it resulted in the increase of directly transported patients and led to the increase of the total number of patients admitted without increasing the proportion of patients with a non-cardiac cause of OHCA. There was no significant change in mortality and neurological outcome.
Out-of-hospital cardiac arrest (OHCA) is a leading cause of death in developed industrial countries. The global worldwide average of OHCA incidence in adults is 95.9/100,000/year. European incidences vary according to source from 16 to 119/100,000/year. The aim of this study was to provide an overview of current information on OHCA. The incidences in various populations are discussed, along with the factors affecting the prognosis and outcome of these patients. The etiology and pathophysiological mechanisms are also described, especially in relation to the most common causes - acute and chronic forms of coronary artery disease and cardiomyopathies. Measures that could improve survival rates are discussed, with emphasis on the role of the general public and deployment of automatic external defibrillators.
- MeSH
- defibrilátory MeSH
- incidence MeSH
- lidé MeSH
- míra přežití MeSH
- prognóza MeSH
- zástava srdce mimo nemocnici epidemiologie etiologie patofyziologie terapie MeSH
- zdravotní výchova MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- MeSH
- antikoagulancia terapeutické užití MeSH
- antithrombiny terapeutické užití MeSH
- embolie a trombóza farmakoterapie prevence a kontrola MeSH
- infarkt myokardu diagnóza chirurgie MeSH
- koronární angiografie metody normy MeSH
- koronární angioplastika metody MeSH
- koronární jednotky pracovní síly MeSH
- lidé MeSH
- týmová péče o pacienty MeSH
- zástava srdce mimo nemocnici * diagnóza etiologie MeSH
- Check Tag
- lidé MeSH
- MeSH
- cerebrovaskulární poruchy etiologie patofyziologie prevence a kontrola MeSH
- lidé MeSH
- medicína založená na důkazech MeSH
- reperfuzní poškození etiologie prevence a kontrola MeSH
- terapeutická hypotermie metody normy škodlivé účinky MeSH
- výsledek terapie MeSH
- zástava srdce mimo nemocnici * etiologie komplikace MeSH
- Check Tag
- lidé MeSH
