INTRODUCTION: Pancreatic cancer is one of the most aggressive tumors diagnosed in local-ly advanced or metastatic stage in more than half of the cases. The standard of care is a systemic chemotherapy but the prognosis of metastatic patients remains extremely poor with a median overall survival less than one year. However, there is increasing evidence of surgery treatment benefit in a carefully selected oligometastatic cases. -Because oligometastatic pancreatic cancer is rare, there is a lack of robust clinical trials defining strategy, efficacy and safety of this procedure. PATIENT CONCERNS: A 77-year-old man presented with a mass in the tail of the pancreas and solitary liver metastasis. After four cycles of chemotherapy, distal pancreatectomy with liver metastasectomy was performed, and the tissues were histologically examined. The complete pathological response was found in the primary tumor and residual adenocarcinoma in liver metastasis. OUTCOMES: The patient is alive without recurrency more than two years from the diagnosis.
- Klíčová slova
- Pancreas, cancer, carcinoma, oligometastatic, pancreas, resection,
- MeSH
- adenokarcinom sekundární farmakoterapie chirurgie MeSH
- lidé MeSH
- metastázektomie MeSH
- nádory jater * sekundární farmakoterapie chirurgie MeSH
- nádory slinivky břišní * patologie farmakoterapie chirurgie sekundární MeSH
- neoadjuvantní terapie * MeSH
- pankreatektomie * MeSH
- protokoly antitumorózní kombinované chemoterapie terapeutické užití MeSH
- senioři MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- kazuistiky MeSH
The guidelines for clinical practice for carriers of pathogenic variants in clinically relevant genes predisposing to Lynch syndrome and colorectal cancer define the steps of primary and secondary prevention that should be provided to the individuals at high risk of developing hereditary cancer in the Czech Republic. The drafting of the guidelines was organized by the Oncogenetics Working Group of the Society for Medical Genetics and Genomics of J. E. Purkyně Czech Medical Society, in cooperation with representatives of oncology, oncogynecology, and gastroenterology. The guidelines are based on the current recommendations of the National Comprehensive Cancer Network (NCCN), European Society of Medical Oncology (ESMO) and take into account the capacity of the Czech healthcare system.
- Klíčová slova
- MLH1, MSH2/EPCAM, MSH6, PMS2, consensus, germline mutation carriers, guidelines for clinical practice,
- MeSH
- adhezní molekula epiteliálních buněk * genetika MeSH
- dědičné nepolypózní kolorektální nádory * genetika MeSH
- DNA vazebné proteiny genetika MeSH
- genetická predispozice k nemoci * MeSH
- homolog 2 proteinu MutS * genetika MeSH
- lidé MeSH
- mismatch repair endonukleáza PMS2 genetika MeSH
- MutL homolog 1 * genetika MeSH
- zárodečné mutace * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- směrnice pro lékařskou praxi MeSH
- Geografické názvy
- Česká republika MeSH
- Názvy látek
- adhezní molekula epiteliálních buněk * MeSH
- DNA vazebné proteiny MeSH
- EPCAM protein, human MeSH Prohlížeč
- G-T mismatch-binding protein MeSH Prohlížeč
- homolog 2 proteinu MutS * MeSH
- mismatch repair endonukleáza PMS2 MeSH
- MLH1 protein, human MeSH Prohlížeč
- MSH2 protein, human MeSH Prohlížeč
- MutL homolog 1 * MeSH
- PMS2 protein, human MeSH Prohlížeč
The Guidelines for Clinical Practice for carriers of pathogenic variants in clinically relevant cancer predisposition genes define the steps of primary and secondary prevention that should be provided to these individuals at high risk of developing hereditary cancer in the Czech Republic. The drafting of the guidelines was organized by the Oncogenetics Working Group of the Society for Medical Genetics and Genomics of J. E. Purkyně Czech Medical Society (SLG ČLS JEP) in cooperation with the representatives of oncology and oncogynecology. The guidelines are based on the current recommendations of the National Comprehensive Cancer Network (NCCN), European Society of Medical Oncology (ESMO) and take into account the capacity of the Czech healthcare system.
- Klíčová slova
- ATM, BRCA1, BRCA2, CHEK2, PALB2, consensus, germline mutation carriers, guidelines for clinical practice,
- MeSH
- ATM protein * genetika MeSH
- checkpoint kinasa 2 * genetika MeSH
- genetická predispozice k nemoci * MeSH
- lidé MeSH
- nádory prostaty genetika MeSH
- nádory prsu genetika MeSH
- nádory slinivky břišní genetika MeSH
- nádory vaječníků genetika MeSH
- protein BRCA1 genetika MeSH
- protein BRCA2 * genetika MeSH
- protein FANCN * genetika MeSH
- směrnice pro lékařskou praxi jako téma MeSH
- zárodečné mutace * MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
- Názvy látek
- ATM protein, human MeSH Prohlížeč
- ATM protein * MeSH
- BRCA1 protein, human MeSH Prohlížeč
- BRCA2 protein, human MeSH Prohlížeč
- checkpoint kinasa 2 * MeSH
- CHEK2 protein, human MeSH Prohlížeč
- PALB2 protein, human MeSH Prohlížeč
- protein BRCA1 MeSH
- protein BRCA2 * MeSH
- protein FANCN * MeSH
This paper presents the gamma-ray detection performance of the newly developed MAPD-3NM-II type SiPM sensor array (4 [Formula: see text] 4) with [Formula: see text](Ce) scintillator. The gamma-ray spectra of various sources have been measured in the energy range from 26 keV up to 1332 keV. The newly developed array based on MAPD-3NM-II sensors proved [Formula: see text] 22% enhancement in energy resolution in comparison to the former MAPD-3NM-I based array. The energy resolution of 662 keV gamma-rays measured by MAPD-3NM-II was 3.3% while clearly surpassing 4.25% resolution of MAPD-3NM-I predecessor. The enhancement is related to the high PDE of the new MAPD-3NM-II. Obtained results show that the new MAPD-3NM-II demonstrated good energy resolution and linearity in the studied energy region. The energy resolution of the new detector developed based on MAPD-3NM-II was better than all previous products of MAPD.
- Publikační typ
- časopisecké články MeSH
A search for exclusive two-photon production via photon exchange in proton-proton collisions, pp→pγγp with intact protons, is presented. The data correspond to an integrated luminosity of 9.4 fb^{-1} collected in 2016 using the CMS and TOTEM detectors at a center-of-mass energy of 13 TeV at the LHC. Events are selected with a diphoton invariant mass above 350 GeV and with both protons intact in the final state, to reduce backgrounds from strong interactions. The events of interest are those where the invariant mass and rapidity calculated from the momentum losses of the forward-moving protons match the mass and rapidity of the central, two-photon system. No events are found that satisfy this condition. Interpreting this result in an effective dimension-8 extension of the standard model, the first limits are set on the two anomalous four-photon coupling parameters. If the other parameter is constrained to its standard model value, the limits at 95% confidence level are |ζ_{1}|<2.9×10^{-13} GeV^{-4} and |ζ_{2}|<6.0×10^{-13} GeV^{-4}.
- Publikační typ
- časopisecké články MeSH
Introduction: Any mass in chronic pancreatitis (CP) is a difficult diagnostic and therapeutic problem. The aim of the study is a) to use our own group to determine the actual incidence of non-malignant masses in CP where any mass is highly suspected of being malignant; and b) to determine the actual incidence of malignant tumors in CP. Methods: We present a retrospective analysis of our group of patients operated in 2015–2019 for CP, a mass in CP and suspected malignancy in the mass in CP. Additionally, we present difficult cases in terms of preoperative diagnosis. Results: Thirty-three of 340 (9.7%) pancreatic resection were done due to any form of chronic pancreatitis in 2015–2019. A mass in the pancreatic head was present in 16 (48%) patients; of these, pancreatic ductal adenocarcinoma (PDAC) was suspected in 10 (62%) patients based on EUS, CT or PETCT, and also based on positive tissue diagnosis using EUS-FNA in 6 cases. Bypass or Frey procedure were done in 59 patients (HJA, PJA, Frey). Preoperative tissue sampling was done in 8 (13%) patients and malignancy was suspected in 25%. Intraoperatively, malignancy was confirmed only in one patient assessed as non-malignant in the preoperative period. The clinical course in 3 other patients undergoing HJA, although tumor-free at the time of the surgery, indicated PDAC in CP. Conclusion: The ability to detect malignant cells in a mass in CP remains poor even using all of the available sophisticated methods and the success depends on many variable factors. The rate of “unnecessary” right-sided resections of a mass in CP reached 48% in our patient group, while the rate of resections which should have been performed instead of bypass procedures was 7%. A certain percentage of the so-called excessive pancreatic resections, as well as the failure to perform a resection due to an undetected/unrecognized pancreatic tumor in CP should continue to be expected.
- Klíčová slova
- Pancreas, Pancreatic cancer, case reports, chronic pancreatitis, non-malignant mass, pancreas, pancreatic cancer,
- MeSH
- chronická pankreatitida * chirurgie MeSH
- nádory slinivky břišní * diagnóza MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Chronic pancreatitis (CP) is a serious condition with a great impact on the quality of life, and it can lead to some serious long-term consequences such as pancreatic cancer or secondary diabetes mellitus. Associated pancreatic exocrine insufficiency leads to malnutrition with weight loss; however, the main symptom of the disease is abdominal pain, often very severe. The primary treatment option for painful CP is pharmacotherapy (pancreatic enzyme replacement therapy, analgesics). If this is not effective, CP can be treated via endoscopy, extracorporeal shockwave lithotripsy (ESWL), their combination, or surgery. We present a case of painful chronic obstructive pancreatitis in a patient successfully treated with ESWL in combination with endoscopy.
- Klíčová slova
- chronic pancreatitis, endoscopy, extracorporeal shockwave lithotripsy, pancreatic duct stones,
- MeSH
- cholangiopankreatografie endoskopická retrográdní MeSH
- kaménky * chirurgie MeSH
- lidé MeSH
- litotripse * MeSH
- výsledek terapie MeSH
- vývody pankreatu MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Environmental conditions to which plants acclimate prior exposure to abiotic or biotic stressors can greatly affect their subsequent resilience. This may have a significant impact on the response to ongoing climate change and can be useful for increasing the food security under adverse weather conditions associated with climate change.Within this study, we tested the hypothesis that plant morphological and biochemical acclimation to radiation conditions and nitrogen (N) availability is closely linked with carbon (C) and N balance. Four barley (Hordeum vulgare) varieties, differing in their morphological characteristics and sensitivity to photooxidative stress, were grown at two levels of N supply and four radiation regimes combining distinct levels of ultraviolet (UV) and photosynthetically active radiation (PAR). Changes in root and shoot morphology, accumulation of phenolic compounds, amino acids, and sugars were studied together with the analysis of C and N content in leaves. Both UV and PAR reduced leaf length and increased root-to-shoot ratio (R:S). Such effect was more pronounced under high N availability. High N supply reduced R:S, but this effect showed significant interactions with UV and PAR, and also with barley variety. Changes in R:S were positively related to C:N ratio in leaves that varied in response to both N availability and radiation treatments. UV radiation, particularly in combination with high PAR intensity, led to increases in most phenolic compounds (particularly flavones such as saponarin, homoorientin and isovitexin) which was also closely associated with changes in C:N ratio, while specifically phenolic acids (vanillic and syringic acids) decreased under high levels of UV and PAR, and hydroxycinnamic acids responded positively mainly to PAR. Although high N availability generally reduced the accumulation of phenolic compounds, this effect was genotype-specific and modulated by the radiation regime. A similar antagonistic effect of radiation treatment and N availability was also found for the accumulation of sugars (pentoses), resulting in a close relationship between the accumulation of pentoses and C:N ratio. The accumulation of most amino acids, in contrary to phenolic compounds, increases at high N and is also stimulated by high PAR and UV intensities. We conclude that radiation conditions and N availability have opposite effects on plant morphology and accumulation of most phenolic compounds and modulate the amino acid and sugar metabolism. Strong associations of these responses with changes in C:N ratio indicates that plant stoichiometry integrates acclimation processes and induction of relevant defence mechanisms.
- Klíčová slova
- Amino acids, Barley, Carbon, Nitrogen, Phenolic compounds, Root to shoot ratio, Sugars,
- MeSH
- dusík MeSH
- fotosyntéza MeSH
- ječmen (rod) * MeSH
- listy rostlin MeSH
- rostliny MeSH
- ultrafialové záření MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- dusík MeSH
We describe an analysis comparing the pp[over ¯] elastic cross section as measured by the D0 Collaboration at a center-of-mass energy of 1.96 TeV to that in pp collisions as measured by the TOTEM Collaboration at 2.76, 7, 8, and 13 TeV using a model-independent approach. The TOTEM cross sections, extrapolated to a center-of-mass energy of sqrt[s]=1.96 TeV, are compared with the D0 measurement in the region of the diffractive minimum and the second maximum of the pp cross section. The two data sets disagree at the 3.4σ level and thus provide evidence for the t-channel exchange of a colorless, C-odd gluonic compound, also known as the odderon. We combine these results with a TOTEM analysis of the same C-odd exchange based on the total cross section and the ratio of the real to imaginary parts of the forward elastic strong interaction scattering amplitude in pp scattering for which the significance is between 3.4σ and 4.6σ. The combined significance is larger than 5σ and is interpreted as the first observation of the exchange of a colorless, C-odd gluonic compound.
- Publikační typ
- časopisecké články MeSH
An understanding of the structural organisation and chemistry of the cell walls in woody tissues is crucial from the perspective of plant mechanical strength, water transportability, as well as subsequent commercial utilisation of the wood. Poplar trees (Populus sp.), grown on two reclamation substrates ("Humus" and "Sand") under the extreme soil conditions of an external coal mining spoil heap of the lignite mine in Bełchatów (Central Poland), were examined. Conventional parameters - tree-ring width (TRW) and wood density (WD) resolved annually (years 2008-2017) were corroborated by a novel approach of Raman spectroscopic analysis. Annually resolved Raman spectroscopic data representing the lignin-to-cellulose ratio (Li/Ce) enabled to estimate trends of lignification. The above traits were obtained for the three poplar genotypes: H-275, Grandis, and Androscoggin to assess the suitability of their plantation on the reclaimed heap. Our results show a significant effect of genotype on TRW, WD, and the Raman Li/Ce, while the effect of the soil substrate was less pronounced. The highest Li/Ce was identified in the H-275 genotype grown on a substrate with hummus. H-275 also showed higher TRW values compared to the other genotypes. WD was significantly higher in Grandis and Androscoggin genotypes grown on the "Sand" substrate. Associations between tree-ring parameters and climatic variables (temperature and precipitation) were mostly low and not statistically significant. Our findings from individual tree rings indicate that the genotype is the crucial factor influencing the lignification of poplar trees grown on post-mining lands.
- Klíčová slova
- Bioenergy, Biomass, External heap, Global change, Lignocellulose, Reclamation,
- MeSH
- dřevo MeSH
- genotyp MeSH
- Populus * genetika MeSH
- půda * MeSH
- uhlí MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Polsko MeSH
- Názvy látek
- půda * MeSH
- uhlí MeSH
