Spindle cell hemangioma is a benign vascular tumor typically occurring in the dermis or subcutis of distal extremities as red-brown lesions that can grow in both size and number over time. They can be very painful and potentially disabling. A family history of cancer or previous history may be relevant and must be taken into consideration. Juxtaglomerular cell tumor (reninoma) is an extremely rare cause of secondary hypertension diagnosed mostly among adolescents and young adults. Excessive renin secretion results in secondary hyperaldosteronism. Subsequent hypokalemia and metabolic alkalosis, together with high blood pressure, are clues for clinical diagnosis. Histological examination of the excised tumor leads to a definitive diagnosis. Reninoma is found in subcapsular localization, in most cases as a solitary mass, in imaging studies of kidneys. Exceptionally, it can be located in another part of a kidney. Both spindle cell hemangioma and reninoma are extremely rare tumors in children and adolescents. Herein, the authors present a case report of a patient with hereditary BRCA1 interacting protein C-terminal helicase 1 (BRIP1) mutation, spindle cell hemangioma, and secondary hypertension caused by atypically localized reninoma.

• Klíčová slova
• children, hypertension, juxtaglomerular cell tumor, kidney, reninoma, spindle cell hemangioendothelioma,
• MeSH
• genetická predispozice k nemoci * MeSH
• hemangiom diagnóza   genetika   patologie   MeSH
• juxtaglomerulární aparát patologie   MeSH
• ledviny metabolismus   patologie   MeSH
• lidé MeSH
• proteiny FANC genetika   MeSH
• RNA-helikasy genetika   MeSH
• zárodečné mutace genetika   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• práce podpořená grantem MeSH
• Názvy látek
• BRIP1 protein, human MeSH Prohlížeč
• proteiny FANC MeSH
• RNA-helikasy MeSH

INTRODUCTION: The finding of the neuroretinal ablation in fovea centralis area on Optic Coherence Tomography (OCT) examination in young men is a typical finding for central serous choroidoretinopathy. This finding may masquerade the presence of the choroidal hemangioma. CASE REPORT: The author presents case reports of two young men, in which, according to the finding of neuroretinal ablation on OCT, the diagnosis of central serous choroidoretinopathy was established. Using following examinations, especially fluorescence angiography, the correct diagnosis of choroidal hemangioma was set. In both patients, the photodynamic therapy with Visudyne was consequently indicated. CONCLUSION: In young patients with slightly decreased visual acuity, neuroretinal ablation finding in the macula on OCT, and without the tendency to spontaneous improvement, it is necessary to keep in the mind the possible presence of choroidal hemangioma.Key words: hemangioma, central serous choroidoretinopathy, misdiagnosis, ablation of the neuroretina, macula, choroid.

• MeSH
• centrální serózní chorioretinopatie diagnóza   farmakoterapie   MeSH
• diferenciální diagnóza MeSH
• dospělí MeSH
• fluoresceinová angiografie MeSH
• fotochemoterapie MeSH
• fotosenzibilizující látky terapeutické užití   MeSH
• hemangiom diagnóza   farmakoterapie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory choroidey diagnóza   farmakoterapie   MeSH
• optická koherentní tomografie MeSH
• porfyriny terapeutické užití   MeSH
• verteporfin MeSH
• zraková ostrost MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• fotosenzibilizující látky MeSH
• porfyriny MeSH
• verteporfin MeSH

OBJECTIVE: To describe a case of prenatal diagnosis of a giant placental chorioangioma with favorable outcome. DESIGN: A case report. SETTING: Gynecology and Obstetrics Service, Federal University of Triângulo Mineiro (UFTM), Uberaba-MG, Brazil. CASE REPORT: The placental chorioangioma is the most common benign tumor, but the type giant has a small prevalence, ranging from 1:16.000 to 1:50.000 pregnancies. We reported a case of a patient aged 18, pregnant for the first time, who performed a routine obstetric ultrasound was found to have polyhydramnios associated with placental vascular lesions suggestive of chorioangioma also was defined by fetal magnetic resonance imaging and confirmed by pathological examination.

• Klíčová slova
• chorioangioma, magnetic resonance imaging., placental, pregnancy, ultrasound,
• MeSH
• diferenciální diagnóza MeSH
• hemangiom diagnóza   diagnostické zobrazování   patologie   chirurgie   MeSH
• lidé MeSH
• mladiství MeSH
• nádorové komplikace v těhotenství diagnóza   diagnostické zobrazování   patologie   MeSH
• nemoci placenty MeSH
• novorozenec MeSH
• těhotenství MeSH
• ultrasonografie prenatální * MeSH
• Check Tag
• lidé MeSH
• mladiství MeSH
• novorozenec MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

BACKGROUND: Spontaneous hepatic bleeding is a rare but potentially life-threatening complication of primary systemic amyloidosis. Although the liver is a common site of amyloid deposition, clinical presentation is usually mild or absent. CASE: We report a case of a female patient, who had been repeatedly surgically revised because of liver rupture and hemoperitoneum. Initially, the computed tomography finding was interpreted as liver hemangioma. However, based on liver biopsy, the diagnosis had to be changed to primary systemic amyloidosis, and the patient was referred to our hematooncology department. Due to a considerably advanced disease, the patient was eligible only for palliative chemotherapy with cyclophosphamide and dexamethasone, which could not deflect the course of rapidly progressing liver destruction. CONCLUSION: The cause behind ruptured and bleeding liver does not always need to be hemangioma but rather amyloidosis. In cases of advanced disease and in patients with contraindications for aggressive treatment, the outlook for complete hematological and organ treatment response is very limited. An early diagnosis is of utmost importance. Although liver biopsy brings the definite results, screening for monoclonal protein in serum or urine, leading to a search for AL amyloidosis, may be sufficient for diagnosis. The presence of some of the warning signs (B-symptoms such as fevers or subfebrile temperatures, fatigue, weight loss; and paraneoplastic laboratory findings such as elevated C-reactive protein and erythrocyte sedimentation rate) should raise suspicion of a lymphoproliferative disease.

• MeSH
• amyloidóza komplikace   diagnóza   MeSH
• diferenciální diagnóza MeSH
• hemangiom diagnóza   MeSH
• hemoperitoneum etiologie   MeSH
• krvácení etiologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory jater diagnóza   MeSH
• nemoci jater diagnóza   etiologie   MeSH
• primární amyloidóza MeSH
• recidiva MeSH
• spontánní ruptura MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• přehledy MeSH

INTRODUCTION AND AIM: Vertebral hemangiomas (VH) are usually asymptomatic and, therefore, are commonly detected as accidental findings on spinal imaging. No treatment is indicated in these cases. Nevertheless, some hemangiomas may clinically manifest as axial pain and neurological deficit and may require surgery or other treatment. The aim of this study was to assess outcomes of surgical management of symptomatic vertebral hemangiomas at two neurosurgical clinics. MATERIAL AND METHODS: Prospective study of patients with symtomatic vertebral hemangioma managed surgically at Neurosurgical Clinic of Faculty Hospital and Medical Faculty (FN and LF UP) of Palacky University in Olomouc and at Neurosurgical Department of Ostrava-Fifejdy Hospital. Surgery was indicated in patients with confirmed thoracic and lumbar vertebral hemangioma, presenting with axial, eventually with radicular pain and/or neurological deficit, such as myelopathy or radicular lesion. In cases where the only basis for indication for surgery was axial lumbar pain, the procedure included only vertebroplasty (VP) of the vertebral body (Vertecem, Synthes, USA). In cases with neurological dysfunction, posterior decompression using hemilaminectomy with extirpation of hemangioma tissue protruding into the spinal canal, as well as vertebroplasty, was indicated. During the 13-month study period, 7 patients aged from 38 to 80 years (the mean age of 60.3 years) were operated. The subjects included 4 males and 3 females. Follow up examinations were performed during hospitalization, at 6 weeks and at 6 months after the procedure. On the last follow up examination, the patients were asked to assess axial and radicular pain based on the VAS scale, ODI and the surgeons evaluated the degree of myelopathy according to Frankel and JOA classification. RESULTS: Vertebroplasty had positive impact on the degree of axial and radicular pain in all subjects (seven patients) and combination of VP with decompression resulted in improvement of myelopathic symptoms in all the subjects concerned (three patients). No spinal canal cement leak or embolization during VP was recorded, neither surgical wound healing complications, such as hematoma or infection, were recorded. No surgical revisions were required. DISCUSSION: The aim of symptomatic vertebral hemangioma therapy include nervous tissue decompression, spinal stabilization and prevention of spontaneous or traumatic epidural bleeding. Nervous tissue decompression using laminectomy or hemilamine- ctomy can be indicated only in patients developing severe paraparesis and may have good outcome. It is advisable to combine decompression with vertebroplasty or balloon kyphoplasty, arterial embolization or intralesional alcohol injection. CONCLUSION: Vertebroplasty resulted in pain score improvement in all patients with symptomatic vertebral hemangiomas. Combinations of vertebroplasty and decompression had positive impact on myelopathic symptoms in all the patients concerned.

• MeSH
• bederní obratle * MeSH
• chirurgická dekomprese MeSH
• dospělí MeSH
• hemangiom diagnóza   chirurgie   MeSH
• hrudní obratle * MeSH
• lidé středního věku MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• nádory páteře diagnóza   chirurgie   MeSH
• počítačová rentgenová tomografie MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• vertebroplastika MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• kazuistiky MeSH

The authors present an interesting case of a suckling baby treated for forearm tumour. All the preoperative examinations including the imaging methods are documented, as are the surgical procedures and the final results. The case report is interesting not only because such surgery is infrequent but also due to the unpredictable progress of the final diagnosis statement. Before surgery the tumour was diagnosed as an organising haematoma; based on clinical and radiological signs the diagnosis subsequently rose to rapidly growing haemangioma or vascular malformation causing arm paresis and vascular supply disorder. The diagnosis was changed to angiolipoma during surgery. The final histopathological statement was: infantile fibrosarcoma. Despite the virtue of imaging methods and meticulous clinical examination, the surgical and histopathological findings are not necessarily absolutely identical. Having presented this particular case the authors would like to share their experience.

• MeSH
• diferenciální diagnóza MeSH
• fibrosarkom krevní zásobení   patologie   chirurgie   MeSH
• hemangiom vrozené   diagnóza   MeSH
• kojenec MeSH
• lidé MeSH
• nádory měkkých tkání krevní zásobení   patologie   chirurgie   MeSH
• nervus ulnaris chirurgie   MeSH
• předloktí * MeSH
• Check Tag
• kojenec MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

Vertebral haemangiomas (VH) are usually asymptomatic and are often found incidentally at spinal examination by imaging methods. Nevertheless, some haemangiomas can be clinically manifested by various degrees of axial pain and neurological deficit. The aim of this report is to show that this is a complex issue that requires a comprehensive approach to its treatment. The author reports on three patients with aggressive forms of cervical and lumbar VH treated by radiation therapy or vertebroplasty and hemilaminectomy with resection of the intraspinal thoratic component of a tumour. He discusses his findings in relation to the scarce data found on this topic in the literature.

• MeSH
• bederní obratle * MeSH
• dospělí MeSH
• hemangiom diagnóza   terapie   MeSH
• krční obratle * MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory páteře diagnóza   terapie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• kazuistiky MeSH

Ethiopathogenesis, diagnostic and treatment of spinal haemangioma remains suggestive topic not only for surgeons. The development of diagnostic imaging methods allows more precise evaluation of the pathology and optimal therapeutic planning. We have many therapeutic modalities: selective embolisation, radiotherapy, vertebroplasty, alcohol ablation and surgery. It depends on radiologic findings and clinical status which of them is used. The treatment of emergent compression is still the domain of surgeon. In the therapy of haemangiomas causing local pain, we prefer less invasive procedures. The interdisciplinary cooperation is required for the successful treatment.

• MeSH
• hemangiom * diagnóza   terapie   MeSH
• lidé MeSH
• nádory páteře * diagnóza   terapie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• přehledy MeSH

Localization of hemangioma in retroperineum causes late diagnosis of the disease. The tumour is usually detected only when the clinical symptoms caused by the pressure of the surrounding tissues occur. This article presents the case of retroperitoneal hemangioma preoperatively diagnosed as suspect feochromocytoma.

• MeSH
• diferenciální diagnóza MeSH
• hemangiom * diagnóza   chirurgie   MeSH
• lidé MeSH
• retroperitoneální nádory * diagnóza   chirurgie   MeSH
• senioři MeSH
• Check Tag
• lidé MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• anglický abstrakt MeSH
• časopisecké články MeSH
• kazuistiky MeSH

OBJECTIVE: We report a case of prenatal diagnosis and postpartum management of a subcutaneous tumor without intracranial communication. METHODS: An occipital tumor without intracranial communication was found on ultrasound scan in the 21st week of pregnancy. Using MRI, the diagnosis was confirmed. Subcutaneous localization of the tumor was verified and communication with intracranial space excluded. RESULTS: The newborn was delivered spontaneously at term and underwent a successful surgical procedure 5 months postpartum. CONCLUSION: The prenatal diagnosis allowed differentiation between a communicating neural tube defect with poor prognosis, and a manageable extracranial subcutaneous tumor. The precise diagnosis of uncomplicated dermal sinus was possible only after the histological evaluation of the tumor confirmed occipital dermal sinus associated with hemangioma.

• MeSH
• hemangiom komplikace   diagnóza   chirurgie   MeSH
• kojenec MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• nádory hlavy a krku komplikace   diagnóza   chirurgie   MeSH
• novorozenec MeSH
• spina bifida occulta komplikace   diagnóza   chirurgie   MeSH
• těhotenství MeSH
• týlní kost MeSH
• ultrasonografie prenatální MeSH
• Check Tag
• kojenec MeSH
• lidé MeSH
• novorozenec MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH