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8 záznamů v PubMed Filtry

Článek

Paneth-like cells in renal cell carcinomas and in cysts associated with acquired cystic kidney disease: Clinicopathologic analysis, comparative study and description of precursor lesions

Kojima, Fumiyoshi
Autor Kojima, Fumiyoshi Department of Human Pathology, Wakayama Medical University, Wakayama, Japan
Alaghehbandan, Reza
Autor Alaghehbandan, Reza Department of Pathology, Faculty of Medicine, University of British Columbia, Royal Columbian Hospital, Vancouver, BC, Canada
Kuroda, Naoto
Autor Kuroda, Naoto Department of Diagnostic Pathology, Kobe Kyodo Hospital, Kobe, Japan
Matsuzaki, Ibu
Autor Matsuzaki, Ibu Department of Human Pathology, Wakayama Medical University, Wakayama, Japan
Mikasa, Yurina
Autor Mikasa, Yurina Department of Human Pathology, Wakayama Medical University, Wakayama, Japan
Musangile, Fidele Y
Autor Musangile, Fidele Y Department of Human Pathology, Wakayama Medical University, Wakayama, Japan
Iwamoto, Ryuta
Autor Iwamoto, Ryuta Department of Human Pathology, Wakayama Medical University, Wakayama, Japan
Takahashi, Yuichi
Autor Takahashi, Yuichi Department of Human Pathology, Wakayama Medical University, Wakayama, Japan
Iwahashi, Yoshifumi
Autor Iwahashi, Yoshifumi Department of Human Pathology, Wakayama Medical University, Wakayama, Japan
Warigaya, Kenji
Autor Warigaya, Kenji Department of Human Pathology, Wakayama Medical University, Wakayama, Japan

Annals of diagnostic pathology. 2021 Apr ; 51 () : 151707. [epub] 20210123

Ann Diagn Pathol
ISSN 1532-8198 | 1092-9134
Zdroj

Paneth-like cells (PLCs) are different from Paneth cells (PCs) and contain Paneth-like granules, which have been reported in non-neoplastic conditions and in neoplasms of various organs. PLCs have been reported in clear cell renal cell carcinoma (CCRCC), but not in non-CCRCC, including acquired cystic disease-associated renal cell carcinoma (ACD-RCC). We analyzed clinicopathological features of 24 acquired cystic disease-associated renal cell carcinoma (ACD-RCC) with PLCs (ACD-RCCP+) and compared with those of 23 ACD-RCCs without PLCs (ACD-RCCP-). Approximately half of ACD-RCCs had PLCs and that almost all kidneys harboring ACD-RCC had cysts with PLCs. The fact that many ACD-RCCs and the cysts had PLCs is further evidence that the cyst with vacuoles and complex architecture might be a precursor lesion for ACD-RCC. The presence of PLCs may provide additional morphologic clue for distinguishing ACD-RCC from PRCC in challenging differential diagnostic workup in acquired cystic disease of the kidney setting.

Klíčová slova
Acquired cystic disease, Acquired cystic disease-associated renal cell carcinoma, Kidney, Paneth-like cell, Precursor lesion,
MeSH
cystická onemocnění ledvin komplikace patologie MeSH
cysty patologie MeSH
diferenciální diagnóza MeSH
dospělí MeSH
karcinom z renálních buněk diagnóza patologie MeSH
ledviny patologie MeSH
lidé středního věku MeSH
lidé MeSH
nádory ledvin patologie MeSH
oxaláty analýza MeSH
Panethovy buňky patologie MeSH
progrese nemoci MeSH
senioři MeSH
staging nádorů metody MeSH
TNF-alfa metabolismus MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
srovnávací studie MeSH
Názvy látek
oxaláty MeSH
TNF-alfa MeSH

Článek

Association of minor and trace elements with mineralogical constituents of urinary stones: a hard nut to crack in existing studies of urolithiasis

Environmental geochemistry and health. 2013 Aug ; 35 (4) : 511-22. [epub] 20130222

Environ Geochem Health
ISSN 1573-2983 | 0269-4042
Zdroj

The role of metals in urinary stone formation has already been studied in several publications. Moreover, urinary calculi can also be used for assessing exposure of humans to minor and trace elements in addition to other biological matrices, for example, blood, urine, or hair. However, using urinary calculi for biomonitoring of trace elements is limited by the association of elements with certain types of minerals. In this work, 614 samples of urinary calculi were subjected to mineralogical and elemental analysis. Inductively coupled plasma mass spectrometry and thermo-oxidation cold vapor atomic absorption spectrometry were used for the determination of major, minor, and trace elements. Infrared spectroscopy was used for mineralogical analysis, and additionally, it was also employed in the calculation of mineralogical composition, based on quantification of major elements and stoichiometry. Results demonstrate the applicability of such an approach in investigating associations of minor and trace elements with mineralogical constituents of stones, especially in low concentrations, where traditional methods of mineralogical analysis are not capable of quantifying mineral content reliably. The main result of this study is the confirmation of association of several elements with struvite (K, Rb) and with calcium phosphate minerals, here calculated as hydroxylapatite (Na, Zn, Sr, Ba, Pb). Phosphates were proved as the most important metal-bearing minerals in urinary calculi. Moreover, a significantly different content was also observed for Fe, Zr, Mo, Cu, Cd, Se, Sn, and Hg in investigated groups of minerals. Examination of such associations is essential, and critical analysis of mineral constituents should precede any comparison of element content among various groups of samples.