Analysis of data from the representative "GGP - Contemporary Czech Family Survey" (2020-2022) on the population of women aged 40-69 years showed that the age of onset of menopause is associated with a low age at the birth of the first child. Women who had their first child before their 20th birthday, a pattern of reproductive behaviour common among generations of women before 1989, have an earlier onset of menopause than older first-time mothers. Conversely, the effect of higher age at first birth (35 years or more) on the delay of menopause has not been proved. However, this issue requires further investigation, as the sample analysed suggests certain tendencies. A larger sample size would be needed to make a conclusive finding.

• Klíčová slova
• menopause, age at menopause, age at first birth,
• MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• menopauza * fyziologie   MeSH
• senioři MeSH
• těhotenství MeSH
• věk matky MeSH
• věkové faktory MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• senioři MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika epidemiologie   MeSH

By oxidation of nitrogen oxide nitrites and nitrates are formed which can be considered markers of inflammation. AGE-substances (products of advanced glycation) are formed not only from proteins (e.g. Hb-AGE) but also from lipids (AGE-LDL) and DNA (AGE-DNA) and lead to an increased number of mutations. They are toxic and are deposited in the vascular wall. They cause coagulopathy, stimulate cytokines and inactivate nitrogen oxide and thus prevent relaxation of the vascular wall. Extracellular superoxide dismutase (EC-SOD) has a variant (mutation Arg213Gly with a 4% incidence) which causes deterioration of the cardiac prognosis. Selenium deficiency leads also to an increased frequency of cardiovascular diseases.

• MeSH
• antioxidancia metabolismus   MeSH
• kardiovaskulární nemoci metabolismus   MeSH
• lidé MeSH
• oxidační stres * MeSH
• produkty pokročilé glykace metabolismus   MeSH
• sloučeniny dusíku metabolismus   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH
• Názvy látek
• antioxidancia MeSH
• produkty pokročilé glykace MeSH
• sloučeniny dusíku MeSH

• MeSH
• duševní poruchy diagnóza   terapie   MeSH
• lidé MeSH
• LSD terapeutické užití   MeSH
• psychoanalytická teorie * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• LSD MeSH

The age distribution of the population of Czechoslovakia in 1984 is described, and the historical factors affecting it are considered.

• Klíčová slova
• Age Distribution *, Age Factors, Czechoslovakia, Demographic Factors, Developed Countries, Eastern Europe *, Europe, Historical Survey *, Population, Population Characteristics *,
• MeSH
• demografie MeSH
• populace MeSH
• populační charakteristiky * MeSH
• věkové faktory MeSH
• věkové rozložení * MeSH
• vyspělé země MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Československo MeSH
• Evropa MeSH
• východní Evropa MeSH

BACKGROUND: Takotsubo syndrome (TTS) occurs predominantly in post-menopausal women but is also found in younger patients. OBJECTIVES: This study aimed to investigate age-related differences in TTS. METHODS: Patients diagnosed with TTS and enrolled in the International Takotsubo Registry between January 2011 and February 2017 were included in this analysis and were stratified by age (younger: ≤50 years, middle-age: 51 to 74 years, elderly: ≥75 years). Baseline characteristics, hospital course, as well as short- and long-term mortality were compared among groups. RESULTS: Of 2,098 TTS patients, 242 (11.5%) patients were ≤50 years of age, 1,194 (56.9%) were 51 to 74 years of age, and 662 (31.6%) were ≥75 years of age. Younger patients were more often men (12.4% vs. 10.9% vs. 6.3%; p = 0.002) and had an increased prevalence of acute neurological (16.3% vs. 8.4% vs. 8.8%; p = 0.001) or psychiatric disorders (14.1% vs. 10.3% vs. 5.6%; p < 0.001) compared with middle-aged and elderly TTS patients. Furthermore, younger patients had more often cardiogenic shock (15.3% vs. 9.1% vs. 8.1%; p = 0.004) and had a numerically higher in-hospital mortality (6.6% vs. 3.6% vs. 5.1%; p = 0.07). At multivariable analysis, younger (odds ratio: 1.60; 95% confidence interval: 0.86 to 3.01; p = 0.14) and older age (odds ratio: 1.09; 95% confidence interval: 0.66 to 1.80; p = 0.75) were not independently associated with in-hospital mortality using the middle-aged group as a reference. There were no differences in 60-day mortality rates among groups. CONCLUSIONS: A substantial proportion of TTS patients are younger than 50 years of age. TTS is associated with severe complications requiring intensive care, particularly in younger patients.

• Klíčová slova
• Takotsubo syndrome, age, broken heart syndrome, outcome,
• MeSH
• celosvětové zdraví MeSH
• duševní poruchy epidemiologie   MeSH
• hodnocení rizik statistika a číselné údaje   MeSH
• kardiogenní šok * epidemiologie   etiologie   MeSH
• kauzalita MeSH
• lidé středního věku MeSH
• lidé MeSH
• mortalita v nemocnicích * MeSH
• mortalita MeSH
• nemoci nervového systému epidemiologie   MeSH
• prevalence MeSH
• prognóza MeSH
• registrace MeSH
• senioři MeSH
• takotsubo kardiomyopatie * komplikace   diagnóza   epidemiologie   patofyziologie   MeSH
• věk při počátku nemoci * MeSH
• věkové faktory * MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

In the selection of young athletes, earlier-born adolescents often leverage their temporary biological advantage over their later-born peers from the same cohort, giving rise to the phenomenon known as the Relative Age Effect (RAE). In this study, we delved into the complexities of the RAE in soccer by reviewing 563 independent research samples across 90 articles. Our analysis showed that age period and performance level are pivotal factors influencing the magnitude of the RAE. The adolescent age period emerged as a significant RAE determinant, showcasing the highest effect size magnitudes in our findings. Among athletes of different performance levels, adult European soccer players have been extensively studied, and they have exhibited the most pronounced RAE magnitudes. Intriguingly, our findings reveal another compelling trend: the frequency of players born early versus late in the eligible birth year escalated as player performance levels increased, particularly during adolescence. Coaches and players appear to capitalize unconsciously on this maturational advantage, though this strategy wanes post-adolescence. While there are currently no penalties for this team selection practice, our findings stress the need for coaches to comprehend the ramifications of selecting athletes with an age bias We offer insights into RAE complexities, highlight the synergy of age and performance in these transitory advantages, and advance arguments for more fairly selecting and developing youth athletes.

• Klíčová slova
• adolescence, age disparity impact, annual grouping, football, performance-driven athlete selection, youth development in sport,
• MeSH
• dospělí MeSH
• fotbal * MeSH
• lidé MeSH
• mladiství MeSH
• sportovci MeSH
• věkové faktory MeSH
• vyrovnaná skupina MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladiství MeSH
• Publikační typ
• časopisecké články MeSH
• metaanalýza MeSH
• přehledy MeSH

BACKGROUND: The answer to the question "At what age does aging begin?" is tightly related to the question "Where is the onset of mortality increase with age?" Age affects mortality rates from all diseases differently than it affects mortality rates from nonbiological causes. Mortality increase with age in adult populations has been modeled by many authors, and little attention has been given to mortality decrease with age after birth. MATERIALS AND METHODS: Nonbiological causes are excluded, and the category "all diseases" is studied. It is analyzed in Denmark, Finland, Norway, and Sweden during the period 1994-2011, and all possible models are screened. Age trajectories of mortality are analyzed separately: before the age category where mortality reaches its minimal value and after the age category. RESULTS: Resulting age trajectories from all diseases showed a strong minimum, which was hidden in total mortality. The inverse proportion between mortality and age fitted in 54 of 58 cases before mortality minimum. The Gompertz model with two parameters fitted as mortality increased with age in 17 of 58 cases after mortality minimum, and the Gompertz model with a small positive quadratic term fitted data in the remaining 41 cases. The mean age where mortality reached minimal value was 8 (95% confidence interval 7.05-8.95) years. The figures depict an age where the human population has a minimal risk of death from biological causes. CONCLUSION: Inverse proportion and the Gompertz model fitted data on both sides of the mortality minimum, and three parameters determined the shape of the age-mortality trajectory. Life expectancy should be determined by the two standard Gompertz parameters and also by the single parameter in the model c/x. All-disease mortality represents an alternative tool to study the impact of age. All results are based on published data.

• Klíčová slova
• Nordic countries, age, all diseases, external causes, mortality,
• MeSH
• lidé středního věku MeSH
• lidé MeSH
• mortalita trendy   MeSH
• naděje dožití trendy   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• stárnutí MeSH
• statistické modely MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Skandinávie a severské státy epidemiologie   MeSH

OBJECTIVE: Pregnancy at advanced maternal age has become more common over the last decades. Therefore, the study aimed to describe the characteristics and maternal and perinatal outcomes of women giving birth at advanced maternal age and very advanced age. METHODS: We conducted a retrospective cohort study of 2,300 singleton births that occurred in 2020-2021 at the Department of Gynaecology and Obstetrics of the Louis Pasteur University Hospital in Košice. The control (age 20-34 years), advanced maternal age (35-39 years), and very advanced maternal age (≥ 40 years) groups included 1,851, 382, and 67 women, respectively. Exclusion criteria were multiple pregnancies, maternal age less than 20 years, smoking and alcohol use, foetal malformation and intrauterine foetal death, and birth weight of 500 grams or less. Data on mothers and newborn infants have been reported from the birth book and the reports on mothers at childbirth. The data were analysed using IBM SPSS Statistics 23.0. RESULTS: Our results confirmed statistically significant differences regarding the rate of preterm birth (p = 0.004), very preterm birth (p = 0.010), caesarean delivery rate (p < 0.001), very low birth weight (p = 0.027), extremely low birth weight (p = 0.001), and Apgar score at 5 minutes < 7 (p = 0.020) between newborns in the compared maternal age groups. CONCLUSION: Advanced maternal age is a prognostic factor for poor pregnancy outcomes. Women of advanced maternal age are at higher risk of adverse obstetric and perinatal outcomes.

• Klíčová slova
• advanced maternal age, birth outcomes, birth weight, preterm birth, risk factors, very advanced maternal age,
• MeSH
• císařský řez statistika a číselné údaje   MeSH
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• novorozenec MeSH
• pokročilý věk matky MeSH
• předčasný porod epidemiologie   MeSH
• retrospektivní studie MeSH
• těhotenství MeSH
• věk matky * MeSH
• výsledek těhotenství * epidemiologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• novorozenec MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

This paper analyses the age structure of the pollenotics yearly examinated at the Allergology and Clinical Immunology Department of the Faculty Hospital at Olomouc. On the base of the obtained statistics we can say that the men's age constitution differs from the women's one. This difference may be a specific feature of the pollenosis as well as a consequence of the age structure of the population and other influences.

• MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• senioři MeSH
• sezónní alergická rýma epidemiologie   MeSH
• věkové faktory MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Československo epidemiologie   MeSH

Extracorporeal cardiopulmonary resuscitation (ECPR) is an advanced technique using extracorporeal membrane oxygenation (ECMO) to support patients with refractory cardiac arrest. Age significantly influences ECPR outcomes, with younger patients generally experiencing better survival and neurological outcomes due to many aspects. This review explores the impact of age on ECPR effectiveness, emphasizing the need to consider age alongside other clinical factors in patient selection. Survival rates differ notably between in-hospital (IHCA) and out-of-hospital cardiac arrest (OHCA), highlighting the importance of rapid intervention. The potential of artificial intelligence to develop predictive models for ECPR outcomes is discussed, aiming to improve decision-making. Ethical considerations around age-based treatment decisions are also addressed. This review advocates for a balanced approach to ECPR, integrating clinical and ethical perspectives to optimize patient outcomes across all age groups.

• Klíčová slova
• ECMO, ECPR, age, cardiopulmonary, extracorporeal, outcomes, resuscitation,
• MeSH
• kardiopulmonální resuscitace metody   MeSH
• lidé MeSH
• mimotělní membránová oxygenace * mortalita   MeSH
• srdeční zástava mortalita   terapie   MeSH
• věkové faktory MeSH
• zástava srdce mimo nemocnici mortalita   terapie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH