Hypertensive disorders in pregnancy are a worldwide health problem for women and their infants complicating up to 10% of pregnancies and associated with increased maternal and neonatal morbidity and mortality. In Europe, 2.3-3% of pregnancies are complicated by preeclampsia. Gestational diabetes, obesity, no previous or multiple births, maternal age less than 20 or greater than 35years old and thrombophilia can be some of the possible factors related to increased risk for hypertension in pregnancy. Complications of hypertension during pregnancy affect both mothers and their infants. Ambulatory blood pressure monitoring helps to distinguish true hypertension from the white coat as pregnant women with office abnormal values may have normal out of office blood pressure. Imbalance between proangiogenic and antiangiogenic factors in placenta may lead to endothelial dysfunction, vasoconstriction, activation of the coagulation system, and hemolysis. Carotid intima-media thickness, pulse wave velocity, augmentation index, and arterial wall tension were found to be significantly increased in women with preeclampsia compared to normotensive pregnant women. Uterine artery Doppler and serum biomarkers can be used to evaluate the probability of hypertension and complications during pregnancy, but further research in the field is needed. Lately, micro ribonucleic acids have also been the focus of research as potential biomarkers.

• Klíčová slova
• Gestational hypertension, Preeclampsia, Pregnancy-induced hypertension,
• MeSH
• ambulantní monitorování krevního tlaku MeSH
• biologické markery krev   MeSH
• hypertenze indukovaná těhotenstvím * diagnóza   epidemiologie   patofyziologie   terapie   MeSH
• kardiovaskulární komplikace v těhotenství krev   epidemiologie   etiologie   MeSH
• krevní tlak fyziologie   MeSH
• lidé MeSH
• těhotenství MeSH
• Check Tag
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• biologické markery MeSH

OBJECTIVE: The aim of this prospective study was to find the association between the factor V Leiden mutation and adverse pregnancy outcomes. METHODS: This study is an analysis of a prospective observational study of the frequency of placenta-mediated complications of factor V Leiden mutation carriers. We compared pregnancy outcomes of 11 women with a heterozygous form of the factor V Leiden mutation with 41 women of a control group. RESULTS: All pregnancies ended with delivery of a living infant. None of the 52 pregnancies were complicated by venous thromboembolism. There were a few significant differences regarding placenta-mediated complications. The gestational age at delivery showed small significant differences. There was a significant difference in the birth weight deviation in percentage between FVL carriers and controls. The incidence of blood loss exceeding 1000 ml was higher in the control group. CONCLUSIONS: Carriership of the factor V Leiden mutation did not affect the incidence of preeclampsia. Adverse pregnancy outcomes such as placental abruption were rare. Eclampsia, intrauterine fetal death and venous thromboembolism did not occur. Our results provide evidence that the maternal heterozygous FVL mutation did not increase the risk of an adverse pregnancy outcome.

• MeSH
• bodová mutace * MeSH
• dospělí MeSH
• faktor V genetika   MeSH
• hematologické komplikace těhotenství genetika   MeSH
• heterozygot * MeSH
• lidé MeSH
• rizikové faktory MeSH
• těhotenství MeSH
• výsledek těhotenství MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• factor V Leiden MeSH Prohlížeč
• faktor V MeSH

In this special edition (closed on 31 October 2022), 4 reviews, 13 original papers, 1 communication, and 1 case report are published [...].

• MeSH
• komplikace těhotenství * etiologie   MeSH
• komunikace * MeSH
• lidé MeSH
• těhotenství MeSH
• Check Tag
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• úvodní články MeSH
• úvodníky MeSH

OBJECTIVE: To investigate whether self-rated health (SRH) in pregnancy can predict childbirth complications, adverse birth outcomes, and maternal health problems up to 3 years after delivery. METHODS: A retrospective analysis was performed of data obtained in a prospective longitudinal population-based birth cohort study. Pregnant women resident in the Brno or Znojmo regions in the Czech Republic were included if they were expected to deliver between March 1991 and June 1992. SRH data were collected between 1991 and 1995 via pen-and-paper questionnaires administered in mid-pregnancy, and at 6 months, 18 months, and 3 years after delivery. Medical records were reviewed for pregnancy complications, childbirth complications, and birth outcomes. Multivariate regression analysis was performed. RESULTS: Overall, 4811 women were included. Better SRH in pregnancy predicted fewer childbirth complications (b=-0.03; P=0.036); lower odds of cesarean delivery (odds ratio 0.81; P=0.003); and fewer maternal health problems at 6 months (b=-0.32; P<0.001), 18 months (b=-0.28; P<0.001), and 3 years after delivery (b=-0.30; P<0.001). The effects of SRH were independent of diagnosed complications and self-reported health problems in pregnancy. CONCLUSION: SRH in pregnancy has predictive value for subsequent health outcomes, and might be an additional tool for assessment of pregnant women's health.

• Klíčová slova
• Birth outcomes, Childbirth complications, Maternal health, Pregnancy, Self-rated health,
• MeSH
• dospělí MeSH
• komplikace porodu epidemiologie   MeSH
• komplikace těhotenství epidemiologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• multivariační analýza MeSH
• odds ratio MeSH
• prediktivní hodnota testů MeSH
• regresní analýza MeSH
• retrospektivní studie MeSH
• rizikové faktory MeSH
• těhotenství MeSH
• vedení porodu statistika a číselné údaje   MeSH
• výsledek těhotenství epidemiologie   MeSH
• zdraví matek * MeSH
• zpráva o sobě * MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH

OBJECTIVE: To study the association between common cold during pregnancy and pregnancy complications and delivery outcomes: gestational age/birth weight, in addition preterm birth and low birthweight. METHOD: In the population-based large data set of the Hungarian Case-Control Surveillance System of Congenital Abnormalities (HCCSCA), 1980-1996, controls without congenital abnormalities were analysed. RESULTS: Of 38,151 newborn infants, 5,475 (14.4%) had mothers with common cold. The prevalence of threatened preterm delivery, placental disorders and severe nausea and vomiting was lower while the occurrence of anemia was higher in pregnant mothers with common cold than in mothers without common cold. Mothers with common cold in pregnancy had 0.1 week shorter gestational age, thus the proportion of preterm births (9.8% vs 9.1%) was somewhat larger. However, mean birth weight was somewhat larger (3,305 vs 3,271 g) and the proportion of low birthweight newborns (4.2% vs 5.9%) was smaller. CONCLUSION: Common cold during pregnancy does not increase the occurrence of pregnancy complications except anemia, while delivery outcomes showed minor but opposite (higher rate of preterm birth and lower rate of low birthweight) changes.

• MeSH
• dospělí MeSH
• gestační stáří MeSH
• komplikace těhotenství * MeSH
• lidé MeSH
• nachlazení * MeSH
• porodní hmotnost MeSH
• těhotenství MeSH
• vedení porodu * MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Maďarsko MeSH

INTRODUCTION: Moderate and high levels of anticardiolipin antibodies (aCL), especially in the setting of the antiphospholipid syndrome, are associated with adverse obstetric outcomes. However, the clinical relevance of low aCL levels (<40 MPL/GPL units) is still a matter of debate. The aim of the study was to evaluate obstetric outcomes in pregnancies with low immunoglobulin M (IgM) and/or immunoglobulin G (IgG) aCL positivity. The association between low aCL positivity and maternal baseline characteristics was also studied. MATERIAL AND METHODS: The retrospective monocentric cohort study of prospectively collected data involved a total 3047 singleton pregnancies that underwent the first-trimester screening involving an aCL test and delivered on site. Obstetric outcomes were compared between the low-titer aCL group (IgM ≥7 MPL units and <40 MPL units and/or IgG ≥10 GPL units and <40 GPL units) and the aCL negative group (IgM <7 MPL units and IgG <10 GPL units, reference group). In addition, obstetric outcomes were evaluated with regard to the antibody isotype: IgM-positive group (IgM <40 MPL units, IgG negative) and IgG-positive group (IgG <40 GPL units, IgM negative or <40 MPL units). RESULTS: Overall, the occurrence of pregnancy-related complications was significantly higher (27.91% vs. 19.32%, p = 0.034) in the low-titer aCL group. Concerning the antibody isotype, a higher rate of pregnancy-related complications was observed in the IgG-positive group (54.55% vs. 19.32%, p = 0.001), but not in the IgM-positive group (22.43% vs. 19.32%, p = 0.454). The stillbirth rate did not reach statistical significance. Low-titer aCL pregnancies were more frequently of advanced maternal age (p < 0.001), suffered from autoimmune diseases (p < 0.001), chronic hypertension (p = 0.040), and hereditary thrombophilia (p = 0.040). In addition, they had more often a positive history of stillbirth (p < 0.001), underwent conception via assisted reproductive technologies (p < 0.001), were administered low-dose aspirin (p < 0.001), low-molecular-weight heparin (p = 0.018) and immunomodulatory drugs (p < 0.001), and delivered earlier (p = 0.018). CONCLUSIONS: Even low aCL levels are associated with a higher incidence of pregnancy-related complications, but only in the case of IgG antibody isotype presence. Screening for aCL in the first trimester has some prognostic value, but further studies are needed to determine whether its potential implementation into routine clinical practice would improve antenatal care.

• Klíčová slova
• anticardiolipin antibodies, first‐trimester screening, pregnancy‐related complications, stillbirth,
• MeSH
• antifosfolipidový syndrom krev   MeSH
• antikardiolipinové protilátky * krev   MeSH
• dospělí MeSH
• imunoglobulin G krev   MeSH
• imunoglobulin M krev   MeSH
• kohortové studie MeSH
• komplikace těhotenství * krev   imunologie   epidemiologie   MeSH
• lidé MeSH
• retrospektivní studie MeSH
• těhotenství MeSH
• výsledek těhotenství MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• antikardiolipinové protilátky * MeSH
• imunoglobulin G MeSH
• imunoglobulin M MeSH

The authors present cases on rare but serious complications in pregnancy and puerperium concerning women with cystic aorta medionecrosis, gallbladder carcinoma and Hodgkin lymphoma. They describe the prognosis of pregnant women and their newborns with oncological and non-oncological malignancies while stressing an individual approach.

• MeSH
• aneurysma hrudní aorty komplikace   patologie   MeSH
• cholecystektomie MeSH
• cysty komplikace   patologie   MeSH
• dospělí MeSH
• fatální výsledek MeSH
• Hodgkinova nemoc komplikace   patologie   MeSH
• koarktace aorty komplikace   patologie   MeSH
• krevní transfuze MeSH
• lidé MeSH
• Marfanův syndrom komplikace   MeSH
• nádorové komplikace v těhotenství patologie   MeSH
• nádory žlučníku komplikace   patologie   MeSH
• nekróza komplikace   MeSH
• novorozenec MeSH
• pitva MeSH
• prenatální péče MeSH
• příčina smrti MeSH
• srdeční tamponáda komplikace   MeSH
• těhotenství MeSH
• výsledek těhotenství MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• novorozenec MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

• Klíčová slova
• PREGNANCY/nutrition and diet *,
• MeSH
• dieta * MeSH
• hodnocení stavu výživy * MeSH
• komplikace těhotenství * MeSH
• lidé MeSH
• těhotenství MeSH
• Check Tag
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

This Special Issue mainly focuses on preeclampsia (PE), haemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome, gestational diabetes mellitus (GDM), foetal growth restriction (FGR), small-for-gestational-age foetuses (SGA), miscarriage, stillbirth, first-episode psychosis (FEP) during pregnancy, and pregnancy-related acute kidney injury (PR-AKI) [...].

• MeSH
• gestační diabetes * MeSH
• komplikace těhotenství * MeSH
• lidé MeSH
• narození mrtvého plodu MeSH
• preeklampsie * MeSH
• růstová retardace plodu MeSH
• těhotenství MeSH
• Check Tag
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• úvodníky MeSH

• Klíčová slova
• ABORTION/prevention and control *,
• MeSH
• hrozící potrat * MeSH
• indukovaný potrat prevence a kontrola   MeSH
• komplikace těhotenství * MeSH
• lidé MeSH
• samovolný potrat * MeSH
• těhotenství MeSH
• Check Tag
• lidé MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH