Aging is a complex process. The first signs of aging become apparent in the third decade of life. Originally transient changes become more apparent and permanent with the time. Aging affects all structures of the face. Aging changes can be divided into three categories: gravitational changes, volume changes and skin changes. Current concept of facial rejuvenation is based upon complex solution. Such as solution must respect patient personal preferences. Most pronounced changes should be addressed first, and invasive surgical procedures should be combined with mini-invasive (lipografting) and non-invasive ones to achieve more natural and longer lasting results. Common types of procedures, their modifications, complications, advantages and disadvantages are described. Typical postoperative result is presented. Keywords: aging, facelift, lipografting, facial rejuvenation.

• Klíčová slova
• aging, facelift, facial rejuvenation, lipografting,
• MeSH
• lidé MeSH
• obličej MeSH
• omlazení MeSH
• rytidoplastika * MeSH
• stárnutí kůže * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

Skin is the external part of the human body; thus, it is exposed to outer stimuli leading to injuries and damage, due to being the tissue mostly affected by wounds and aging that compromise its protective function. The recent extension of the average lifespan raises the interest in products capable of counteracting skin related health conditions. However, the skin barrier is not easy to permeate and could be influenced by different factors. In the last decades an innovative pharmacotherapeutic approach has been possible thanks to the advent of nanomedicine. Nanodevices can represent an appropriate formulation to enhance the passive penetration, modulate drug solubility and increase the thermodynamic activity of drugs. Here, we summarize the recent nanotechnological approaches to maintain and replace skin homeostasis, with particular attention to nanomaterials applications on wound healing, regeneration and rejuvenation of skin tissue. The different nanomaterials as nanofibers, hydrogels, nanosuspensions, and nanoparticles are described and in particular we highlight their main chemical features that are useful in drug delivery and tissue regeneration.

• Klíčová slova
• cellular mechanisms, nanomaterials, regenerative medicine, skin, stem cells,
• MeSH
• fyziologie kůže účinky léků   MeSH
• kůže metabolismus   MeSH
• lidé MeSH
• nanostruktury terapeutické užití   MeSH
• omlazení * MeSH
• regenerace účinky léků   MeSH
• systémy cílené aplikace léků * MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

PURPOSE: We propose a new method of genital rejuvenation based on absorbable thread insertion. In this study, we aimed to assess the safety and efficacy of particular absorbable threads made of P (LA/CL), the so-called Nano Spring 7, for vulvar rejuvenation. PATIENTS AND METHODS: The study was conducted in two parts: the first by anatomical dissection and the second by clinical study. The first part of the study clarified safety and efficacy of thread insertion in this anatomical area. During the second part, 19 patients underwent Nano Spring 7 absorbable thread insertion in the subcutaneous layer of the labia majora to improve esthetic parameters and were followed up after 7, 30, 90, and 180 days. We evaluated outcomes using four different patients' questionnaires and one investigator's questionnaire. RESULTS: The anatomical dissection defined the correct anatomical layer of threads implantation and the subcutaneous structures allowing for the thread anchoring. All the patients completed the study. The patients' and investigators' subjective evaluations during follow-up and at the end of the study were very positive. All the patients showed a decrease in discomfort sensations related to the labia majora conditions and aesthetic improvement in the vulvar area and recommended the treatment to their friends. CONCLUSION: The use of absorbable threads is an innovative, safe minimally invasive approach to genital rejuvenation.

• Klíčová slova
• genital rejuvenation, non-surgical rejuvenation, threads in polylactic acid, threads in spring shape,
• Publikační typ
• časopisecké články MeSH

• Klíčová slova
• COLLAGEN/chemistry *,
• MeSH
• extracelulární matrix * MeSH
• kolagen chemie   MeSH
• omlazení * MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• kolagen MeSH

Photoaging is an inevitable occurrence for people who have a fair skin type, who live in a sunny climate, and who enjoy the outdoors. In the past the remedies for this condition were limited to dermabrasion or chemical peeling. Both dermabrasion and chemical peels have hazards of their own. With phenol peels, cardiac and renal toxicity was real concern. There is an increasing demand for an effective and safe laser treatment that repairs photoaged skin. Two treatment modalities, ablative skin resurfacing (ASR), and nonablative dermal remodeling (NDR), have been developed to address this demand. All currently available laser treatments, however, exhibit significant problems, and these laser systems typically operate safely and effectively only over a narrow, patient-dependent treatment range. This study aimed to analyze a new protocol of fractional rejuvenation and intense pulsed light for skin rejuvenation regarding its efficacy, safety, and complications. Twenty-nine patients (27 women and 2 men), age ranging from 40 to 73 years, answered the questionnaire and were included in the study. The use of intense pulsed light after the fractional rejuvenation allows us to enhance the effects of this new procedure especially in skin pigmentation disorders and telangiectasia and to continue to stimulate the deep dermal component.

• MeSH
• dospělí MeSH
• fototerapie metody   MeSH
• kohortové studie MeSH
• kosmetické techniky * MeSH
• lidé středního věku MeSH
• lidé MeSH
• omlazení * MeSH
• senioři MeSH
• spokojenost pacientů MeSH
• stárnutí kůže * MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Endoscopic facial rejuvenation is a new technique which allows to greatly reduce the scar morbidity especially in the forehead region. Other advantages are its safety and accuracy due to the excellent magnification provided by the endoscope which enhances the visualization of muscles, nerves and vessels and shows clear surgical planes. Anyway, a sound knowledge of the distribution of the fascial system at the temporo-zygomatic region and of the relationships between the temporal fasciae, the interposed fat pads and the frontal branch are fundamental both in the prevention of nerve injury and in the successful result of the endoscopic procedure. In this paper an accurate account of the anatomical structures and their relationships encountered during a subperiosteal endoscopic facial procedure by dissecting 20 facial halves has been provided.

• MeSH
• endoskopie * MeSH
• fascie anatomie a histologie   MeSH
• lidé MeSH
• mrtvola MeSH
• nervus facialis anatomie a histologie   MeSH
• rytidoplastika metody   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

BACKGROUND: Radio frequency (RF) and chemical peels have been used for nonablative skin rejuvenation. Both of these cause collagen remodeling in the dermis and neo-collagen formation resulting in facial rejuvenation. There is limited literature on the evaluation of collagen remodeling by objective methods. OBJECTIVE: To compare the benefits of monopolar radiofrequency and glycolic acid peels in facial rejuvenation with regards to histopathology and Ultrabiomicroscopic sonography (UBM). METHODOLOGY: In this study, forty patients with mild to moderate photoaging received four treatments with 3 weeks interval of monopolar radiofrequency on one side of face and glycolic acid peels in increasing concentrations (NeostrataR) on the other side. Pre and post treatment, 2 mm biopsies were taken from both preauricular areas and Ultrasonography using a 35 MHz probe was done from outer canthus of eye and nasolabial folds from both sides of face. A blinded assessment was done to measure the increase in the grenz zone and dermal thickness. RESULTS: In 35/40 patients there was a significant increase in the grenz zone on histopathology and decrease in subepidermal low-echogenic band (SLEB) on UBM of the nasolabial folds on both sides of the face (p < 0.05). CONCLUSION: Radiofrequency and chemical peels showed equal efficacy in the treatment of facial rejuvenation.

• Klíčová slova
• Chemical peels, Grenz zone, Radiofrequency, SLEB,
• MeSH
• chemická exfoliace metody   MeSH
• dospělí MeSH
• elektrostimulační terapie přístrojové vybavení   MeSH
• glykoláty aplikace a dávkování   MeSH
• keratolytika aplikace a dávkování   MeSH
• lidé středního věku MeSH
• lidé MeSH
• obličej * patologie   MeSH
• omlazení * MeSH
• rádiové vlny * MeSH
• spokojenost pacientů MeSH
• stárnutí kůže * účinky léků   patologie   účinky záření   MeSH
• výsledek terapie MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH
• Názvy látek
• glycolic acid MeSH Prohlížeč
• glykoláty MeSH
• keratolytika MeSH

• Klíčová slova
• ENDOMETRIUM/neoplasms *, MESENCHYMOMA *, OVARIES/neoplasms *, REJUVENATION *,
• MeSH
• endometrium * MeSH
• lidé MeSH
• mezenchymom * MeSH
• nádory * MeSH
• omlazení * MeSH
• ovarium * MeSH
• sarkom * MeSH
• Check Tag
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

From an evolutionary perspective, ageing is a decrease in fitness with chronological age - expressed by an increase in mortality risk and/or decline in reproductive success and mediated by deterioration of functional performance. While this makes ageing intuitively paradoxical - detrimental to individual fitness - evolutionary theory offers answers as to why ageing has evolved. In this review, I first briefly examine the classic evolutionary theories of ageing and their empirical tests, and highlight recent findings that have advanced our understanding of the evolution of ageing (condition-dependent survival, positive pleiotropy). I then provide an overview of recent theoretical extensions and modifications that accommodate those new discoveries. I discuss the role of indeterminate (asymptotic) growth for lifetime increases in fecundity and ageing trajectories. I outline alternative views that challenge a universal existence of senescence - namely the lack of a germ-soma distinction and the ability of tissue replacement and retrogression to younger developmental stages in modular organisms. I argue that rejuvenation at the organismal level is plausible, but includes a return to a simple developmental stage. This may exempt a particular genotype from somatic defects but, correspondingly, removes any information acquired during development. A resolution of the question of whether a rejuvenated individual is the same entity is central to the recognition of whether current evolutionary theories of ageing, with their extensions and modifications, can explain the patterns of ageing across the Tree of Life.

• Klíčová slova
• Gene-by-environment interactions, Germ-soma distinction, Intraspecific ageing rate, Modified mutation accumulation, Rejuvenation, Retrogression,
• MeSH
• biologická adaptace genetika   MeSH
• biologická evoluce * MeSH
• fertilita genetika   MeSH
• genetická pleiotropie MeSH
• lidé MeSH
• mutace * MeSH
• omlazení fyziologie   MeSH
• rozmnožování genetika   MeSH
• stárnutí genetika   MeSH
• zárodečné buňky růst a vývoj   metabolismus   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH

Soft tissue fillers used for facial rejuvenation can cause complications. We present two cases of late migration of injected fillers mimicking other pathology in the periocular area. Case 1 is a 52-year-old woman referred with chronic bilateral upper lid swelling, mimicking blepharochalasis syndrome, 51/2 years after undergoing injection of hyaluronic acid filler in both brows. Extensive blood investigations were normal. Bilateral, sequential upper lid biopsy revealed migrated hyaluronic acid filler, which was successfully treated with hyaluronidase. Case 2 is a 62-year-old woman who presented with a right lower lid mass 8 years after undergoing injection of polyalkylimide gel into both cheeks. CT scanning confirmed an intermediate density soft tissue mass overlying the inferior orbital rim. Histology from surgical excision reported chronic granulomatous inflammation due to migrated polyalkylimide gel. An awareness of late migration of fillers causing eyelid swelling and masses in the periocular area will prevent unnecessary investigations and facilitate prompt management.

• Klíčová slova
• dermatology, ophthalmology, pathology, unwanted effects / adverse reactions,
• MeSH
• hyaluronoglukosaminidasa MeSH
• kosmetické techniky * MeSH
• kyselina hyaluronová MeSH
• lidé středního věku MeSH
• lidé MeSH
• oční víčka diagnostické zobrazování   MeSH
• omlazení MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• hyaluronoglukosaminidasa MeSH
• kyselina hyaluronová MeSH