-
Something wrong with this record ?
Meningococcal adhesion suppresses proapoptotic gene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells
Linhartova I., Basler M., Ichikawa J., Pelicic V., Osicka R., Lory S., Nassif X., Sebo P.
Language English Country Netherlands
NLK
ProQuest Central
from 1996-01-01 to 2012-12-31
Medline Complete (EBSCOhost)
from 2006-01-01 to 2014-12-15
Health & Medicine (ProQuest)
from 1996-01-01 to 2012-12-31
Wiley Online Library (archiv)
from 1997-01-01 to 2012-12-31
Public Health Database (ProQuest)
from 1996-01-01 to 2012-12-31
- MeSH
- Apoptosis immunology MeSH
- Bacterial Adhesion MeSH
- Bacterial Proteins genetics MeSH
- Cell Culture Techniques MeSH
- Cytoprotection genetics MeSH
- Embryo, Mammalian metabolism MeSH
- Endothelial Cells microbiology MeSH
- Financing, Organized MeSH
- Humans MeSH
- Membrane Proteins genetics deficiency MeSH
- Neisseria meningitidis pathogenicity MeSH
- Fimbriae Proteins genetics deficiency MeSH
- Flow Cytometry MeSH
- RNA, Complementary MeSH
- Oligonucleotide Array Sequence Analysis MeSH
- Signal Transduction MeSH
- Gene Expression Profiling MeSH
- Up-Regulation MeSH
- Umbilical Veins cytology MeSH
- Inflammation genetics MeSH
- Check Tag
- Humans MeSH
Neisseria meningitidis colonizes the human nasopharynx and occasionally causes lethal or damaging septicemia and meningitis. Here, we examined the adherence-mediated signaling of meningococci to human cells by comparing gene expression profiles of human umbilical vein endothelial cells (HUVEC) infected by adherent wild-type, frpC-deficient mutant, or the nonadherent (DeltapilD) N. meningitidis. Pili-mediated adhesion of meningococci resulted in alterations of expression levels of human genes known to regulate apoptosis, cell proliferation, inflammatory response, adhesion and genes for signaling pathway proteins such as TGF-beta/Smad, Wnt/beta-catenin and Notch/Jagged. This reveals that adhering piliated meningocci manipulate host signaling pathways controlling cell proliferation while establishing a commensal relationship.
- 000
- 00000naa 2200000 a 4500
- 001
- bmc07523532
- 003
- CZ-PrNML
- 005
- 20111210135727.0
- 008
- 090519s2006 ne e eng||
- 009
- AR
- 040 __
- $a ABA008 $b cze $c ABA008 $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Linhartová, Irena $7 xx0063474
- 245 10
- $a Meningococcal adhesion suppresses proapoptotic gene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells / $c Linhartova I., Basler M., Ichikawa J., Pelicic V., Osicka R., Lory S., Nassif X., Sebo P.
- 314 __
- $a Laboratory of Molecular Biology of Bacterial Pathogens, Institute of Microbiology, Czech Academy of Sciences, Prague, Czech Republic
- 520 9_
- $a Neisseria meningitidis colonizes the human nasopharynx and occasionally causes lethal or damaging septicemia and meningitis. Here, we examined the adherence-mediated signaling of meningococci to human cells by comparing gene expression profiles of human umbilical vein endothelial cells (HUVEC) infected by adherent wild-type, frpC-deficient mutant, or the nonadherent (DeltapilD) N. meningitidis. Pili-mediated adhesion of meningococci resulted in alterations of expression levels of human genes known to regulate apoptosis, cell proliferation, inflammatory response, adhesion and genes for signaling pathway proteins such as TGF-beta/Smad, Wnt/beta-catenin and Notch/Jagged. This reveals that adhering piliated meningocci manipulate host signaling pathways controlling cell proliferation while establishing a commensal relationship.
- 650 _2
- $a apoptóza $x imunologie $7 D017209
- 650 _2
- $a bakteriální adheze $7 D001422
- 650 _2
- $a bakteriální proteiny $x genetika $7 D001426
- 650 _2
- $a buněčné kultury $7 D018929
- 650 _2
- $a cytoprotekce $x genetika $7 D019610
- 650 _2
- $a embryo savčí $x metabolismus $7 D004622
- 650 _2
- $a endoteliální buňky $x mikrobiologie $7 D042783
- 650 _2
- $a proteiny fimbrií $x genetika $x nedostatek $7 D036781
- 650 _2
- $a průtoková cytometrie $7 D005434
- 650 _2
- $a stanovení celkové genové exprese $7 D020869
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a zánět $x genetika $7 D007249
- 650 _2
- $a membránové proteiny $x genetika $x nedostatek $7 D008565
- 650 _2
- $a Neisseria meningitidis $x patogenita $7 D009345
- 650 _2
- $a sekvenční analýza hybridizací s uspořádaným souborem oligonukleotidů $7 D020411
- 650 _2
- $a RNA komplementární $7 D018075
- 650 _2
- $a signální transdukce $7 D015398
- 650 _2
- $a venae umbilicales $x cytologie $7 D014471
- 650 _2
- $a upregulace $7 D015854
- 650 _2
- $a financování organizované $7 D005381
- 700 1_
- $a Basler, Marek $7 xx0106858
- 700 1_
- $a Ichikawa, J.
- 700 1_
- $a Pelicic, V.
- 700 1_
- $a Osička, Radim, $d 1973- $7 nlk20030127803
- 700 1_
- $a Lory, S.
- 700 1_
- $a Nassif, X.
- 700 1_
- $a Šebo, Peter, $d 1960- $7 uk2008403106
- 773 0_
- $w MED00001792 $t FEMS microbiology letters $g Roč. 263, č. 1 (2006), s. 109-118 $x 0378-1097
- 910 __
- $a ABA008 $b x $y 9
- 990 __
- $a 20090519102933 $b ABA008
- 991 __
- $a 20111101104245 $b ABA008
- 999 __
- $a ok $b bmc $g 655570 $s 508880
- BAS __
- $a 3
- BMC __
- $a 2006 $b 263 $c 1 $d 109-118 $i 0378-1097 $m FEMS microbiology letters $x MED00001792
- LZP __
- $a 2009-B2/dkme
